diff --git a/CPAC/nuisance/nuisance.py b/CPAC/nuisance/nuisance.py
index 871d18d232..94a24d14fe 100644
--- a/CPAC/nuisance/nuisance.py
+++ b/CPAC/nuisance/nuisance.py
@@ -2419,6 +2419,8 @@ def nuisance_regressors_generation(
     space: Literal["T1w", "bold"],
 ) -> tuple[Workflow, dict]:
     """Generate nuisance regressors."""
+    if not opt:
+        return wf, {}
     prefixes = [f"space-{space}_"] * 2
     reg_tool = None
     if space == "T1w":
@@ -2659,6 +2661,8 @@ def nuisance_regression(wf, cfg, strat_pool: StratPool, pipe_num, opt, space, re
 
     outputs : dict
     """
+    if not opt:
+        return wf, {}
     opt = strat_pool.regressor_dct
     bandpass = "Bandpass" in opt
     bandpass_before = (