Clump (), LD, and Power #415
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Gitpranavs
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Hi everyone,
I hope you're doing well. I have a question regarding the clump() function and I'm seeking some suggestions from the community. Specifically, I'm wondering if there might be a way to incorporate larger instruments and account for LD (linkage disequilibrium), rather than removing weakly-correlated SNPs.
Currently, I'm encountering a problem when running the clump() function, as it results in a very small sample size of significant SNPs. To provide more context, the exposures I'm working with are derived from multiple meta-analyses of large GWAS.
I would greatly appreciate any insights, suggestions, or comments that anyone may have in terms of tackling this issue.
Thank you all in advance for your time and assistance!
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