Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

[BUG]: Fatal Data Error in IEU Open Gwas #473

Open
shaopopper opened this issue Feb 3, 2024 · 0 comments
Open

[BUG]: Fatal Data Error in IEU Open Gwas #473

shaopopper opened this issue Feb 3, 2024 · 0 comments
Labels

Comments

@shaopopper
Copy link

To IEU Open Gwas project:
First of all, I would like to express my gratitude to you for providing us with a convenient API interface for conducting rapid Mendelian randomization research and analysis, IEU OpenGWAS project (mrcieu.ac.uk.
Recently, when I was calling immune cell data, the ID from ebi-a-GCST90001391 to ebi-a-GCST90002121, I both use the API and dowload the VCF files. I found some the information of some GWAS data after chr 7 was missing. But, I dowload the origanl data from GWAS Catalog, There is indeed information after chromosome 7. Current or future studies published using this omics data will pose serious data issues. Wish you should conduct a data review.
c34d

Additional information:

Origanl Data From:
Complex genetic signatures in immune cells underlie autoimmunity and inform therapy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517961/

Issue ID: ebi-a-GCST90001490, ebi-a-GCST90001895, ebi-a-GCST90001764, ebi-a-GCST90001676 et.. ALL 17

Issue example.
ebi-a-GCST90001490 data from API and VCF:
1 2 3 4 5
1181797 1285662 1087647 1084802 991947
6 7 8 9 10
282216 0 0 0 0
11 12 13 14 15
0 0 0 0 0
16 17 18 19 20
0 0 0 0 0 ......

ebi-a-GCST90001490 data from GWAS Catalog:
1 2 3 4 5 6 7 8 9
1436388 1614194 1316206 1308731 1199582 1191580 1088767 1046759 779529
10 11 12 13 14 15 16 17 18
911358 904772 865600 660523 .......

@shaopopper shaopopper added the bug label Feb 3, 2024
Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
Projects
None yet
Development

No branches or pull requests

1 participant