diff --git a/paddle/cinn/ir/group_schedule/tactic/tile_first_general_tactic.cc b/paddle/cinn/ir/group_schedule/tactic/tile_first_general_tactic.cc
index f9cdb3f10c9407..82e6fcc7fe54fd 100644
--- a/paddle/cinn/ir/group_schedule/tactic/tile_first_general_tactic.cc
+++ b/paddle/cinn/ir/group_schedule/tactic/tile_first_general_tactic.cc
@@ -45,6 +45,100 @@ bool UseContinuousDataTile(const ScheduleConfig& config) {
   return false;
 }
 
+using BoundVariableMap = std::unordered_map<std::string, std::vector<Var>>;
+
+/*
+ * Check if the current loop variable containing the vectorize axis
+ * is present in the iter values of the axis bind within the loop body.
+ * If it is present, the loop cannot be vectorized.
+ * For example, the following loop cannot be vectorized:
+ *
+ * serial for (append_var_0_append_var_1_append_var_2_fused, 0ll, 2304ll)
+ * {
+ *   ScheduleBlock(var_30) {
+ *     i0_29 = axis.bind(append_var_3_i_append_var_4_append_var_5_fused)
+ *     if (((append_var_3_i_append_var_4_append_var_5_fused / 32ll) == 0ll))
+ *       var_30[i0_29] = ((0.899999976f * var_17[i0_29]) + (0.100000024f *
+ * var_2[0ll, i0_29, 0ll, 0ll]))
+ *   }
+ * }
+ */
+bool ContainsVectorizableAxis(const ir::IRSchedule* sch,
+                              const size_t vectorize_axis,
+                              const std::string& block_id) {
+  auto loops = sch->GetLoops(block_id);
+  auto vectorize_expr = loops[vectorize_axis];
+
+  VLOG(4) << "Checking ContainsVectorizableAxis on block: [" << block_id
+          << "], loop:\n"
+          << sch->GetModule().GetExprs().front() << "\n vectorize expr:]\n"
+          << vectorize_expr;
+
+  // Get all the lter values in the axis bind that contain a loop var and the
+  // corresponding iter var.
+  auto get_bound_variables = [&vectorize_expr](const Expr& expr,
+                                               const Expr& loop_var) {
+    BoundVariableMap bound_variable_map;
+    auto loop_var_name = loop_var.as_var()->name;
+
+    ir::ir_utils::CollectIRNodes(
+        expr,
+        [&loop_var_name, &bound_variable_map](const Expr* x) {
+          if (const auto block_realize = x->As<ir::ScheduleBlockRealize>()) {
+            auto* schedule_block =
+                block_realize->schedule_block.As<ScheduleBlock>();
+            auto iter_values = block_realize->iter_values;
+            auto iter_vars = schedule_block->iter_vars;
+
+            for (std::size_t i = 0; i < iter_values.size(); ++i) {
+              const auto& iter_value = iter_values[i];
+              if (iter_value.is_var() &&
+                  iter_value.as_var()->name.find(loop_var_name) !=
+                      std::string::npos) {
+                bound_variable_map[loop_var_name].emplace_back(iter_vars[i]);
+              } else if (iter_value.is_index()) {
+                ir::ir_utils::CollectIRNodes(
+                    iter_value,
+                    [&loop_var_name, &bound_variable_map, &iter_vars, i](
+                        const Expr* x) {
+                      if (const auto* var = x->As<ir::_Var_>()) {
+                        if (var->name == loop_var_name) {
+                          bound_variable_map[loop_var_name].emplace_back(
+                              iter_vars[i]);
+                        }
+                      }
+                      return false;
+                    });
+              }
+            }
+          }
+          return false;
+        },
+        true);
+
+    return bound_variable_map;
+  };
+
+  auto bound_variable_map = get_bound_variables(
+      vectorize_expr, vectorize_expr.As<ir::For>()->loop_var);
+
+  VLOG(5) << "bound_variable_map:\n";
+  for (const auto& entry : bound_variable_map) {
+    const auto& loop_var_name = entry.first;
+    const auto& vars = entry.second;
+    VLOG(5) << "Loop Variable: " << loop_var_name;
+    for (const auto& var : vars) {
+      VLOG(5) << "Var: " << var;
+    }
+  }
+
+  if (bound_variable_map.empty()) {
+    return false;
+  }
+
+  return true;
+}
+
 bool ScheduleBlockEnableVectorize(const ScheduleConfig& config,
                                   const std::string& block_id) {
   if (!config.base_info->enable_vectorize) return false;
@@ -555,18 +649,28 @@ void TileFirstGeneralTactic::ApplyVectorize(ir::IRSchedule* sch,
     };
 
     auto loops = sch->GetLoops(block_id);
-    if (sp_loop > 1) {
-      sch->Split(loops[0],
-                 std::vector<int>{-1, sp_loop, sp_thread, vectorize_factor});
+    // The iter_value bound by axis_bind must contain the loop_var of the axis
+    // to be vectorized.
+    if (ContainsVectorizableAxis(sch, loops.size() - 1, block_id)) {
+      if (sp_loop > 1) {
+        sch->Split(loops[0],
+                   std::vector<int>{-1, sp_loop, sp_thread, vectorize_factor});
+      } else {
+        sch->Split(loops[0], std::vector<int>{-1, sp_thread, vectorize_factor});
+      }
+
+      // set vectorize schedule primitives
+      loops = sch->GetLoops(block_id);
+      auto vectorize_axis = loops.size() - 1;
+      sch->Vectorize(loops[vectorize_axis], vectorize_factor);
     } else {
-      sch->Split(loops[0], std::vector<int>{-1, sp_thread, vectorize_factor});
+      if (sp_loop > 1) {
+        sch->Split(loops[0], std::vector<int>{-1, sp_loop, sp_thread});
+      } else {
+        sch->Split(loops[0], std::vector<int>{-1, sp_thread});
+      }
     }
 
-    // set vectorize schedule primitives
-    loops = sch->GetLoops(block_id);
-    auto vectorize_axis = loops.size() - 1;
-    sch->Vectorize(loops[vectorize_axis], vectorize_factor);
-
     loops = sch->GetLoops(block_id);
     DoBind(loops);
     return;
@@ -576,20 +680,34 @@ void TileFirstGeneralTactic::ApplyVectorize(ir::IRSchedule* sch,
   // only deal with spatial block and don't support blockIdx.y
   if (!IsReductionSBlock(sch->GetBlock(block_id))) {
     auto loops = sch->GetLoops(block_id);
-    sch->Split(loops[1], std::vector<int>{-1, rd_thread, vectorize_factor});
+    // The iter_value bound by axis_bind must contain the loop_var of the axis
+    // to be vectorized.
+    if (ContainsVectorizableAxis(sch, loops.size() - 1, block_id)) {
+      sch->Split(loops[1], std::vector<int>{-1, rd_thread, vectorize_factor});
 
-    // set vectorize schedule primitives
-    loops = sch->GetLoops(block_id);
-    auto vectorize_axis = loops.size() - 1;
-    sch->Vectorize(loops[vectorize_axis], vectorize_factor);
-    const auto DoBind = [&](const std::vector<ir::Expr>& loops) {
-      sch->Bind(loops[0], "blockIdx.x");
-      auto threadsIdx_x_axis = vectorize_axis - 1;
-      sch->Bind(loops[threadsIdx_x_axis], "threadIdx.x");
-    };
-    loops = sch->GetLoops(block_id);
-    DoBind(loops);
-    return;
+      // set vectorize schedule primitives
+      loops = sch->GetLoops(block_id);
+      auto vectorize_axis = loops.size() - 1;
+      sch->Vectorize(loops[vectorize_axis], vectorize_factor);
+      const auto DoBind = [&](const std::vector<ir::Expr>& loops) {
+        sch->Bind(loops[0], "blockIdx.x");
+        auto threadsIdx_x_axis = vectorize_axis - 1;
+        sch->Bind(loops[threadsIdx_x_axis], "threadIdx.x");
+      };
+      loops = sch->GetLoops(block_id);
+      DoBind(loops);
+      return;
+    } else {
+      sch->Split(loops[1], std::vector<int>{-1, rd_thread});
+      const auto DoBind = [&](const std::vector<ir::Expr>& loops) {
+        sch->Bind(loops[0], "blockIdx.x");
+        auto threadsIdx_x_axis = loops.size() - 1;
+        sch->Bind(loops[threadsIdx_x_axis], "threadIdx.x");
+      };
+      loops = sch->GetLoops(block_id);
+      DoBind(loops);
+      return;
+    }
   }
   return;
 }