diff --git a/docs/zh-CN/components/form/options.md b/docs/zh-CN/components/form/options.md
index 7c224d5713e..6c232a84493 100755
--- a/docs/zh-CN/components/form/options.md
+++ b/docs/zh-CN/components/form/options.md
@@ -1609,3 +1609,4 @@ order: 2
 | itemHeight       | `number`                                                                          | `32`      | 每个选项的高度，用于虚拟渲染                                                 |
 | virtualThreshold | `number`                                                                          | `100`     | 在选项数量超过多少时开启虚拟渲染                                             |
 | valuesNoWrap     | `boolean`                                                                         | `false`   | 默认情况下多选所有选项都会显示，通过这个可以最多显示一行，超出的部分变成 ... |
+| clearValueOnSourceChange   | `boolean`              |                        | `source`从数据域取值时，数据域值变化后是否自动清空 |
diff --git a/packages/amis-core/src/renderers/Options.tsx b/packages/amis-core/src/renderers/Options.tsx
index 62007bb3381..d6b717d71e1 100644
--- a/packages/amis-core/src/renderers/Options.tsx
+++ b/packages/amis-core/src/renderers/Options.tsx
@@ -196,6 +196,11 @@ export interface FormOptionsControl extends FormBaseControl {
    * 选项删除提示文字。
    */
   deleteConfirmText?: string;
+
+  /**
+   * source从数据域取值时，数据域值变化后是否自动清空
+   */
+  clearValueOnSourceChange?: boolean;
 }
 
 export interface OptionsBasicConfig extends FormItemBasicConfig {
@@ -434,7 +439,8 @@ export function registerOptionsControl(config: OptionsConfig) {
             formItem.loadOptionsFromDataScope(
               props.source as string,
               props.data,
-              this.changeOptionValue
+              this.changeOptionValue,
+              props.clearValueOnSourceChange
             );
 
             this.normalizeValue();
diff --git a/packages/amis-core/src/store/formItem.ts b/packages/amis-core/src/store/formItem.ts
index b6d18ba4d56..f6aaa13d06c 100644
--- a/packages/amis-core/src/store/formItem.ts
+++ b/packages/amis-core/src/store/formItem.ts
@@ -866,7 +866,12 @@ export const FormItemStore = StoreNode.named('FormItemStore')
     function loadOptionsFromDataScope(
       source: string,
       ctx: Record<string, any>,
-      onChange?: (value: any) => void
+      onChange?: (
+        value: any,
+        submitOnChange?: boolean,
+        changeImmediately?: boolean
+      ) => void,
+      clearValue?: boolean
     ) {
       let options: any[] = resolveVariableAndFilter(source, ctx, '| raw');
 
@@ -892,6 +897,13 @@ export const FormItemStore = StoreNode.named('FormItemStore')
 
       setOptions(options, onChange, ctx);
 
+      // source从数据域获取，同时发生变化时，需要清空当前表单项
+      if (clearValue && !self.selectFirst) {
+        self.selectedOptions.some((item: any) => item.__unmatched) &&
+          onChange &&
+          onChange('', false, true);
+      }
+
       return options;
     }