diff --git a/poetry.lock b/poetry.lock
index dc34f93..88786c5 100644
--- a/poetry.lock
+++ b/poetry.lock
@@ -1,3 +1,5 @@
+# This file is automatically @generated by Poetry and should not be changed by hand.
+
 [[package]]
 name = "apsw"
 version = "3.36.0.post1"
@@ -5,6 +7,13 @@ description = "Another Python SQLite Wrapper"
 category = "main"
 optional = false
 python-versions = "*"
+files = [
+    {file = "apsw-3.36.0.post1-cp35-cp35m-manylinux1_x86_64.whl", hash = "sha256:d396abb633c35b4bf03398066922b48532f553868fd7a08db2be29fde5ba18bc"},
+    {file = "apsw-3.36.0.post1-cp36-cp36m-manylinux1_x86_64.whl", hash = "sha256:ad0a88931f9db5a466c0e38e3d9cfb797b574d6b2b99ab02a92c14ba6f998bda"},
+    {file = "apsw-3.36.0.post1-cp37-cp37m-manylinux1_x86_64.whl", hash = "sha256:9d3a388ee77df80d9445a1098751af24c1bb81ce254e9b677da9416615d23327"},
+    {file = "apsw-3.36.0.post1-cp38-cp38-manylinux1_x86_64.whl", hash = "sha256:4cdc22cfdfe379ecb387878341f8275e5f47af66316b23249160576fc5269193"},
+    {file = "apsw-3.36.0.post1-cp39-cp39-manylinux1_x86_64.whl", hash = "sha256:961132e2006a335770560406da97882b25057fd5243468871470dbd2e887092b"},
+]
 
 [[package]]
 name = "atomicwrites"
@@ -13,6 +22,10 @@ description = "Atomic file writes."
 category = "dev"
 optional = false
 python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*"
+files = [
+    {file = "atomicwrites-1.4.0-py2.py3-none-any.whl", hash = "sha256:6d1784dea7c0c8d4a5172b6c620f40b6e4cbfdf96d783691f2e1302a7b88e197"},
+    {file = "atomicwrites-1.4.0.tar.gz", hash = "sha256:ae70396ad1a434f9c7046fd2dd196fc04b12f9e91ffb859164193be8b6168a7a"},
+]
 
 [[package]]
 name = "attrs"
@@ -21,12 +34,16 @@ description = "Classes Without Boilerplate"
 category = "dev"
 optional = false
 python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*, !=3.4.*"
+files = [
+    {file = "attrs-21.2.0-py2.py3-none-any.whl", hash = "sha256:149e90d6d8ac20db7a955ad60cf0e6881a3f20d37096140088356da6c716b0b1"},
+    {file = "attrs-21.2.0.tar.gz", hash = "sha256:ef6aaac3ca6cd92904cdd0d83f629a15f18053ec84e6432106f7a4d04ae4f5fb"},
+]
 
 [package.extras]
-dev = ["coverage[toml] (>=5.0.2)", "hypothesis", "pympler", "pytest (>=4.3.0)", "six", "mypy", "pytest-mypy-plugins", "zope.interface", "furo", "sphinx", "sphinx-notfound-page", "pre-commit"]
-docs = ["furo", "sphinx", "zope.interface", "sphinx-notfound-page"]
-tests = ["coverage[toml] (>=5.0.2)", "hypothesis", "pympler", "pytest (>=4.3.0)", "six", "mypy", "pytest-mypy-plugins", "zope.interface"]
-tests_no_zope = ["coverage[toml] (>=5.0.2)", "hypothesis", "pympler", "pytest (>=4.3.0)", "six", "mypy", "pytest-mypy-plugins"]
+dev = ["coverage[toml] (>=5.0.2)", "furo", "hypothesis", "mypy", "pre-commit", "pympler", "pytest (>=4.3.0)", "pytest-mypy-plugins", "six", "sphinx", "sphinx-notfound-page", "zope.interface"]
+docs = ["furo", "sphinx", "sphinx-notfound-page", "zope.interface"]
+tests = ["coverage[toml] (>=5.0.2)", "hypothesis", "mypy", "pympler", "pytest (>=4.3.0)", "pytest-mypy-plugins", "six", "zope.interface"]
+tests-no-zope = ["coverage[toml] (>=5.0.2)", "hypothesis", "mypy", "pympler", "pytest (>=4.3.0)", "pytest-mypy-plugins", "six"]
 
 [[package]]
 name = "bcrypt"
@@ -35,6 +52,18 @@ description = "Modern password hashing for your software and your servers"
 category = "main"
 optional = false
 python-versions = ">=3.6"
+files = [
+    {file = "bcrypt-3.2.0-cp36-abi3-macosx_10_10_universal2.whl", hash = "sha256:b589229207630484aefe5899122fb938a5b017b0f4349f769b8c13e78d99a8fd"},
+    {file = "bcrypt-3.2.0-cp36-abi3-macosx_10_9_x86_64.whl", hash = "sha256:c95d4cbebffafcdd28bd28bb4e25b31c50f6da605c81ffd9ad8a3d1b2ab7b1b6"},
+    {file = "bcrypt-3.2.0-cp36-abi3-manylinux1_x86_64.whl", hash = "sha256:63d4e3ff96188e5898779b6057878fecf3f11cfe6ec3b313ea09955d587ec7a7"},
+    {file = "bcrypt-3.2.0-cp36-abi3-manylinux2010_x86_64.whl", hash = "sha256:cd1ea2ff3038509ea95f687256c46b79f5fc382ad0aa3664d200047546d511d1"},
+    {file = "bcrypt-3.2.0-cp36-abi3-manylinux2014_aarch64.whl", hash = "sha256:cdcdcb3972027f83fe24a48b1e90ea4b584d35f1cc279d76de6fc4b13376239d"},
+    {file = "bcrypt-3.2.0-cp36-abi3-manylinux_2_17_x86_64.manylinux2014_x86_64.manylinux_2_24_x86_64.whl", hash = "sha256:a0584a92329210fcd75eb8a3250c5a941633f8bfaf2a18f81009b097732839b7"},
+    {file = "bcrypt-3.2.0-cp36-abi3-musllinux_1_1_x86_64.whl", hash = "sha256:56e5da069a76470679f312a7d3d23deb3ac4519991a0361abc11da837087b61d"},
+    {file = "bcrypt-3.2.0-cp36-abi3-win32.whl", hash = "sha256:a67fb841b35c28a59cebed05fbd3e80eea26e6d75851f0574a9273c80f3e9b55"},
+    {file = "bcrypt-3.2.0-cp36-abi3-win_amd64.whl", hash = "sha256:81fec756feff5b6818ea7ab031205e1d323d8943d237303baca2c5f9c7846f34"},
+    {file = "bcrypt-3.2.0.tar.gz", hash = "sha256:5b93c1726e50a93a033c36e5ca7fdcd29a5c7395af50a6892f5d9e7c6cfbfb29"},
+]
 
 [package.dependencies]
 cffi = ">=1.1"
@@ -51,6 +80,58 @@ description = "Foreign Function Interface for Python calling C code."
 category = "main"
 optional = false
 python-versions = "*"
+files = [
+    {file = "cffi-1.15.0-cp27-cp27m-macosx_10_9_x86_64.whl", hash = "sha256:c2502a1a03b6312837279c8c1bd3ebedf6c12c4228ddbad40912d671ccc8a962"},
+    {file = "cffi-1.15.0-cp27-cp27m-manylinux1_i686.whl", hash = "sha256:23cfe892bd5dd8941608f93348c0737e369e51c100d03718f108bf1add7bd6d0"},
+    {file = "cffi-1.15.0-cp27-cp27m-manylinux1_x86_64.whl", hash = "sha256:41d45de54cd277a7878919867c0f08b0cf817605e4eb94093e7516505d3c8d14"},
+    {file = "cffi-1.15.0-cp27-cp27m-win32.whl", hash = "sha256:4a306fa632e8f0928956a41fa8e1d6243c71e7eb59ffbd165fc0b41e316b2474"},
+    {file = "cffi-1.15.0-cp27-cp27m-win_amd64.whl", hash = "sha256:e7022a66d9b55e93e1a845d8c9eba2a1bebd4966cd8bfc25d9cd07d515b33fa6"},
+    {file = "cffi-1.15.0-cp27-cp27mu-manylinux1_i686.whl", hash = "sha256:14cd121ea63ecdae71efa69c15c5543a4b5fbcd0bbe2aad864baca0063cecf27"},
+    {file = "cffi-1.15.0-cp27-cp27mu-manylinux1_x86_64.whl", hash = "sha256:d4d692a89c5cf08a8557fdeb329b82e7bf609aadfaed6c0d79f5a449a3c7c023"},
+    {file = "cffi-1.15.0-cp310-cp310-macosx_10_9_x86_64.whl", hash = "sha256:0104fb5ae2391d46a4cb082abdd5c69ea4eab79d8d44eaaf79f1b1fd806ee4c2"},
+    {file = "cffi-1.15.0-cp310-cp310-macosx_11_0_arm64.whl", hash = "sha256:91ec59c33514b7c7559a6acda53bbfe1b283949c34fe7440bcf917f96ac0723e"},
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+    {file = "cffi-1.15.0-cp39-cp39-manylinux_2_17_s390x.manylinux2014_s390x.whl", hash = "sha256:ef1f279350da2c586a69d32fc8733092fd32cc8ac95139a00377841f59a3f8d8"},
+    {file = "cffi-1.15.0-cp39-cp39-win32.whl", hash = "sha256:2a23af14f408d53d5e6cd4e3d9a24ff9e05906ad574822a10563efcef137979a"},
+    {file = "cffi-1.15.0-cp39-cp39-win_amd64.whl", hash = "sha256:3773c4d81e6e818df2efbc7dd77325ca0dcb688116050fb2b3011218eda36139"},
+    {file = "cffi-1.15.0.tar.gz", hash = "sha256:920f0d66a896c2d99f0adbb391f990a84091179542c205fa53ce5787aff87954"},
+]
 
 [package.dependencies]
 pycparser = "*"
@@ -62,6 +143,9 @@ description = "cgatcore : the Computational Genomics Analysis Toolkit"
 category = "main"
 optional = false
 python-versions = "*"
+files = [
+    {file = "cgatcore-0.6.9.tar.gz", hash = "sha256:2be6be6721e8be06aabb3ab7f315746e9793d3043363d10387e73c35ad98d8a8"},
+]
 
 [[package]]
 name = "colorama"
@@ -70,25 +154,54 @@ description = "Cross-platform colored terminal text."
 category = "main"
 optional = false
 python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*, !=3.4.*"
+files = [
+    {file = "colorama-0.4.4-py2.py3-none-any.whl", hash = "sha256:9f47eda37229f68eee03b24b9748937c7dc3868f906e8ba69fbcbdd3bc5dc3e2"},
+    {file = "colorama-0.4.4.tar.gz", hash = "sha256:5941b2b48a20143d2267e95b1c2a7603ce057ee39fd88e7329b0c292aa16869b"},
+]
 
 [[package]]
 name = "cryptography"
-version = "35.0.0"
+version = "39.0.1"
 description = "cryptography is a package which provides cryptographic recipes and primitives to Python developers."
 category = "main"
 optional = false
 python-versions = ">=3.6"
+files = [
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 [package.dependencies]
 cffi = ">=1.12"
 
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-pep8test = ["black", "flake8", "flake8-import-order", "pep8-naming"]
-sdist = ["setuptools_rust (>=0.11.4)"]
+docs = ["sphinx (>=5.3.0)", "sphinx-rtd-theme (>=1.1.1)"]
+docstest = ["pyenchant (>=1.6.11)", "sphinxcontrib-spelling (>=4.0.1)", "twine (>=1.12.0)"]
+pep8test = ["black", "check-manifest", "mypy", "ruff", "types-pytz", "types-requests"]
+sdist = ["setuptools-rust (>=0.11.4)"]
 ssh = ["bcrypt (>=3.1.5)"]
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+test = ["hypothesis (>=1.11.4,!=3.79.2)", "iso8601", "pretend", "pytest (>=6.2.0)", "pytest-benchmark", "pytest-cov", "pytest-shard (>=0.1.2)", "pytest-subtests", "pytest-xdist", "pytz"]
+test-randomorder = ["pytest-randomly"]
+tox = ["tox"]
 
 [[package]]
 name = "flake8"
@@ -97,6 +210,10 @@ description = "the modular source code checker: pep8 pyflakes and co"
 category = "dev"
 optional = false
 python-versions = ">=3.6"
+files = [
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 [package.dependencies]
 mccabe = ">=0.6.0,<0.7.0"
@@ -110,10 +227,39 @@ description = "Coroutine-based network library"
 category = "main"
 optional = false
 python-versions = ">=2.7,!=3.0.*,!=3.1.*,!=3.2.*,!=3.3.*,!=3.4.*,!=3.5"
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+]
 
 [package.dependencies]
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 greenlet = {version = ">=1.1.0,<2.0", markers = "platform_python_implementation == \"CPython\""}
+setuptools = "*"
 "zope.event" = "*"
 "zope.interface" = "*"
 
@@ -121,8 +267,8 @@ greenlet = {version = ">=1.1.0,<2.0", markers = "platform_python_implementation
 dnspython = ["dnspython (>=1.16.0,<2.0)", "idna"]
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+recommended = ["backports.socketpair", "cffi (>=1.12.2)", "dnspython (>=1.16.0,<2.0)", "idna", "psutil (>=5.7.0)", "selectors2"]
+test = ["backports.socketpair", "cffi (>=1.12.2)", "contextvars (==2.4)", "coverage (>=5.0)", "coveralls (>=1.7.0)", "dnspython (>=1.16.0,<2.0)", "futures", "idna", "mock", "objgraph", "psutil (>=5.7.0)", "requests", "selectors2"]
 
 [[package]]
 name = "greenlet"
@@ -131,9 +277,66 @@ description = "Lightweight in-process concurrent programming"
 category = "main"
 optional = false
 python-versions = ">=2.7,!=3.0.*,!=3.1.*,!=3.2.*,!=3.3.*,!=3.4.*"
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-docs = ["sphinx"]
+docs = ["Sphinx"]
 
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 name = "iniconfig"
@@ -142,6 +345,10 @@ description = "iniconfig: brain-dead simple config-ini parsing"
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 python-versions = "*"
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 name = "mccabe"
@@ -150,6 +357,10 @@ description = "McCabe checker, plugin for flake8"
 category = "dev"
 optional = false
 python-versions = "*"
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 name = "packaging"
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 category = "dev"
 optional = false
 python-versions = ">=3.6"
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+]
 
 [package.dependencies]
 numpy = [
@@ -198,6 +509,10 @@ description = "SSH2 protocol library"
 category = "main"
 optional = false
 python-versions = "*"
+files = [
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+]
 
 [package.dependencies]
 bcrypt = ">=3.1.3"
@@ -206,9 +521,9 @@ pynacl = ">=1.0.1"
 six = "*"
 
 [package.extras]
-all = ["pyasn1 (>=0.1.7)", "pynacl (>=1.0.1)", "bcrypt (>=3.1.3)", "invoke (>=1.3)", "gssapi (>=1.4.1)", "pywin32 (>=2.1.8)"]
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-gssapi = ["pyasn1 (>=0.1.7)", "gssapi (>=1.4.1)", "pywin32 (>=2.1.8)"]
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+ed25519 = ["bcrypt (>=3.1.3)", "pynacl (>=1.0.1)"]
+gssapi = ["gssapi (>=1.4.1)", "pyasn1 (>=0.1.7)", "pywin32 (>=2.1.8)"]
 invoke = ["invoke (>=1.3)"]
 
 [[package]]
@@ -218,6 +533,10 @@ description = "plugin and hook calling mechanisms for python"
 category = "dev"
 optional = false
 python-versions = ">=3.6"
+files = [
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+]
 
 [package.extras]
 dev = ["pre-commit", "tox"]
@@ -230,6 +549,10 @@ description = "library with cross-python path, ini-parsing, io, code, log facili
 category = "dev"
 optional = false
 python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*, !=3.4.*"
+files = [
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+]
 
 [[package]]
 name = "pycodestyle"
@@ -238,6 +561,10 @@ description = "Python style guide checker"
 category = "dev"
 optional = false
 python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*, !=3.4.*"
+files = [
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+]
 
 [[package]]
 name = "pycparser"
@@ -246,6 +573,10 @@ description = "C parser in Python"
 category = "main"
 optional = false
 python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*"
+files = [
+    {file = "pycparser-2.21-py2.py3-none-any.whl", hash = "sha256:8ee45429555515e1f6b185e78100aea234072576aa43ab53aefcae078162fca9"},
+    {file = "pycparser-2.21.tar.gz", hash = "sha256:e644fdec12f7872f86c58ff790da456218b10f863970249516d60a5eaca77206"},
+]
 
 [[package]]
 name = "pyflakes"
@@ -254,6 +585,10 @@ description = "passive checker of Python programs"
 category = "dev"
 optional = false
 python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*"
+files = [
+    {file = "pyflakes-2.4.0-py2.py3-none-any.whl", hash = "sha256:3bb3a3f256f4b7968c9c788781e4ff07dce46bdf12339dcda61053375426ee2e"},
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+]
 
 [[package]]
 name = "pynacl"
@@ -262,497 +597,7 @@ description = "Python binding to the Networking and Cryptography (NaCl) library"
 category = "main"
 optional = false
 python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*"
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-ruffus = [
+
+[[package]]
+name = "ruffus"
+version = "2.8.4"
+description = "Light-weight Python Computational Pipeline Management"
+category = "main"
+optional = false
+python-versions = "*"
+files = [
     {file = "ruffus-2.8.4.tar.gz", hash = "sha256:6cd3d96e459a1aedcc10341f14fddedfdc13664551757fcd429a241de63826aa"},
 ]
-six = [
+
+[[package]]
+name = "setuptools"
+version = "67.2.0"
+description = "Easily download, build, install, upgrade, and uninstall Python packages"
+category = "main"
+optional = false
+python-versions = ">=3.7"
+files = [
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+[package.extras]
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+testing = ["build[virtualenv]", "filelock (>=3.4.0)", "flake8 (<5)", "flake8-2020", "ini2toml[lite] (>=0.9)", "jaraco.envs (>=2.2)", "jaraco.path (>=3.2.0)", "pip (>=19.1)", "pip-run (>=8.8)", "pytest (>=6)", "pytest-black (>=0.3.7)", "pytest-checkdocs (>=2.4)", "pytest-cov", "pytest-enabler (>=1.3)", "pytest-flake8", "pytest-mypy (>=0.9.1)", "pytest-perf", "pytest-timeout", "pytest-xdist", "tomli-w (>=1.0.0)", "virtualenv (>=13.0.0)", "wheel"]
+testing-integration = ["build[virtualenv]", "filelock (>=3.4.0)", "jaraco.envs (>=2.2)", "jaraco.path (>=3.2.0)", "pytest", "pytest-enabler", "pytest-xdist", "tomli", "virtualenv (>=13.0.0)", "wheel"]
+
+[[package]]
+name = "six"
+version = "1.16.0"
+description = "Python 2 and 3 compatibility utilities"
+category = "main"
+optional = false
+python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*"
+files = [
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 ]
-sqlalchemy = [
+
+[[package]]
+name = "sqlalchemy"
+version = "1.4.27"
+description = "Database Abstraction Library"
+category = "main"
+optional = false
+python-versions = "!=3.0.*,!=3.1.*,!=3.2.*,!=3.3.*,!=3.4.*,!=3.5.*,>=2.7"
+files = [
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@@ -914,19 +907,90 @@ sqlalchemy = [
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 ]
-toml = [
+
+[package.dependencies]
+greenlet = {version = "!=0.4.17", markers = "python_version >= \"3\" and (platform_machine == \"aarch64\" or platform_machine == \"ppc64le\" or platform_machine == \"x86_64\" or platform_machine == \"amd64\" or platform_machine == \"AMD64\" or platform_machine == \"win32\" or platform_machine == \"WIN32\")"}
+
+[package.extras]
+aiomysql = ["aiomysql", "greenlet (!=0.4.17)"]
+aiosqlite = ["aiosqlite", "greenlet (!=0.4.17)", "typing-extensions (!=3.10.0.1)"]
+asyncio = ["greenlet (!=0.4.17)"]
+asyncmy = ["asyncmy (>=0.2.3)", "greenlet (!=0.4.17)"]
+mariadb-connector = ["mariadb (>=1.0.1)"]
+mssql = ["pyodbc"]
+mssql-pymssql = ["pymssql"]
+mssql-pyodbc = ["pyodbc"]
+mypy = ["mypy (>=0.910)", "sqlalchemy2-stubs"]
+mysql = ["mysqlclient (>=1.4.0)", "mysqlclient (>=1.4.0,<2)"]
+mysql-connector = ["mysql-connector-python"]
+oracle = ["cx-oracle (>=7)", "cx-oracle (>=7,<8)"]
+postgresql = ["psycopg2 (>=2.7)"]
+postgresql-asyncpg = ["asyncpg", "greenlet (!=0.4.17)"]
+postgresql-pg8000 = ["pg8000 (>=1.16.6)"]
+postgresql-psycopg2binary = ["psycopg2-binary"]
+postgresql-psycopg2cffi = ["psycopg2cffi"]
+pymysql = ["pymysql", "pymysql (<1)"]
+sqlcipher = ["sqlcipher3-binary"]
+
+[[package]]
+name = "toml"
+version = "0.10.2"
+description = "Python Library for Tom's Obvious, Minimal Language"
+category = "dev"
+optional = false
+python-versions = ">=2.6, !=3.0.*, !=3.1.*, !=3.2.*"
+files = [
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 ]
-tqdm = [
+
+[[package]]
+name = "tqdm"
+version = "4.63.0"
+description = "Fast, Extensible Progress Meter"
+category = "main"
+optional = false
+python-versions = "!=3.0.*,!=3.1.*,!=3.2.*,!=3.3.*,>=2.7"
+files = [
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 ]
-"zope.event" = [
+
+[package.dependencies]
+colorama = {version = "*", markers = "platform_system == \"Windows\""}
+
+[package.extras]
+dev = ["py-make (>=0.1.0)", "twine", "wheel"]
+notebook = ["ipywidgets (>=6)"]
+telegram = ["requests"]
+
+[[package]]
+name = "zope.event"
+version = "4.5.0"
+description = "Very basic event publishing system"
+category = "main"
+optional = false
+python-versions = "*"
+files = [
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 ]
-"zope.interface" = [
+
+[package.dependencies]
+setuptools = "*"
+
+[package.extras]
+docs = ["Sphinx"]
+test = ["zope.testrunner"]
+
+[[package]]
+name = "zope.interface"
+version = "5.4.0"
+description = "Interfaces for Python"
+category = "main"
+optional = false
+python-versions = ">=2.7, !=3.0.*, !=3.1.*, !=3.2.*, !=3.3.*, !=3.4.*"
+files = [
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@@ -979,3 +1043,16 @@ tqdm = [
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 ]
+
+[package.dependencies]
+setuptools = "*"
+
+[package.extras]
+docs = ["Sphinx", "repoze.sphinx.autointerface"]
+test = ["coverage (>=5.0.3)", "zope.event", "zope.testing"]
+testing = ["coverage (>=5.0.3)", "zope.event", "zope.testing"]
+
+[metadata]
+lock-version = "2.0"
+python-versions = "^3.8"
+content-hash = "625fb09805560d48dc4fdcaaf506fa184c3cd0795d506d1fb1e28f3e153bbf61"