From 89d4e5c5002782b168ffcf8e337b0a2f5c5119bf Mon Sep 17 00:00:00 2001
From: "Alex H. Wagner, PhD" <Alex.Wagner@nationwidechildrens.org>
Date: Sat, 9 Nov 2024 22:38:30 -0500
Subject: [PATCH] draft solution to ga4gh/gks-metaschema#35

---
 .../def/VariantPathogenicityStatement.rst      | 18 ++++++------------
 1 file changed, 6 insertions(+), 12 deletions(-)

diff --git a/schema/va-spec/acmg-2015/def/VariantPathogenicityStatement.rst b/schema/va-spec/acmg-2015/def/VariantPathogenicityStatement.rst
index 49e4942..eb328f9 100644
--- a/schema/va-spec/acmg-2015/def/VariantPathogenicityStatement.rst
+++ b/schema/va-spec/acmg-2015/def/VariantPathogenicityStatement.rst
@@ -6,17 +6,11 @@
 
 A Statement describing the role of a variant in causing an inherited condition.
 
-**Information Model**
+**Profile Conditions**
 
+This class adds the following conditions to the :ref:`variant-pathogenicity-statement-profile`:
 
-.. list-table::
-   :class: clean-wrap
-   :header-rows: 1
-   :align: left
-   :widths: auto
-
-   *  - Field
-      - Flags
-      - Type
-      - Limits
-      - Description
+- `VariantPathogenicityStatement.classification` is additionally defined as 
+  *The ACMG 2015 classification of the variant's pathogenicity*.
+    - `.classification.label` is constrained to values `pathogenic`, `likely pathogenic`,
+      `uncertain significance`, `likely benign`, and `benign`.