From c525c0e78fbafb80a1acc308767f3e5042b52d4a Mon Sep 17 00:00:00 2001
From: jonca79 <54137490+jonca79@users.noreply.github.com>
Date: Mon, 26 Feb 2024 14:22:21 +0100
Subject: [PATCH 1/2] fix: make umi tmb similar to tmb

---
 config/config.yaml | 12 ++++++------
 1 file changed, 6 insertions(+), 6 deletions(-)

diff --git a/config/config.yaml b/config/config.yaml
index 25e074b9..44ce0463 100644
--- a/config/config.yaml
+++ b/config/config.yaml
@@ -336,17 +336,17 @@ tmb:
   nssnv_tmb_correction: 0.84
 
 tmb_umi:
-  af_lower_limit: 0.000
+  af_lower_limit: 0.006
   af_upper_limit: 0.994
-  af_germline_lower_limit: 0.3
-  af_germline_upper_limit: 0.7
+  af_germline_lower_limit: 0.47
+  af_germline_upper_limit: 0.53
   artifacts: ""
   background_panel: ""
   db1000g_limit: 0.0001
-  dp_limit: 300
+  dp_limit: 100
   gnomad_limit: 0.0001
-  vd_limit: 0
-  nr_avg_germline_snvs: 0.0
+  vd_limit: 15
+  nr_avg_germline_snvs: 2.0
   nssnv_tmb_correction: 0.84
 
 vardict:

From ef2bcaf3cf842166d1c779f6800712e89e8e06b7 Mon Sep 17 00:00:00 2001
From: jonca79 <54137490+jonca79@users.noreply.github.com>
Date: Mon, 26 Feb 2024 14:24:54 +0100
Subject: [PATCH 2/2] fix: min 1% AF

---
 config/config.yaml | 4 ++--
 1 file changed, 2 insertions(+), 2 deletions(-)

diff --git a/config/config.yaml b/config/config.yaml
index 44ce0463..8e4a7739 100644
--- a/config/config.yaml
+++ b/config/config.yaml
@@ -336,8 +336,8 @@ tmb:
   nssnv_tmb_correction: 0.84
 
 tmb_umi:
-  af_lower_limit: 0.006
-  af_upper_limit: 0.994
+  af_lower_limit: 0.01
+  af_upper_limit: 0.99
   af_germline_lower_limit: 0.47
   af_germline_upper_limit: 0.53
   artifacts: ""