diff --git a/CHANGELOG-cat-969.md b/CHANGELOG-cat-969.md
new file mode 100644
index 0000000000..08c48e56ef
--- /dev/null
+++ b/CHANGELOG-cat-969.md
@@ -0,0 +1,2 @@
+- Adjust homepage queries to exclude donors/samples without descended datasets.
+- Adjust homepage queries to exclude datasets in a non-QA/Published state.
diff --git a/context/app/static/js/components/home/EntityCounts/hooks.ts b/context/app/static/js/components/home/EntityCounts/hooks.ts
index 32ffd2ec33..46317036a3 100644
--- a/context/app/static/js/components/home/EntityCounts/hooks.ts
+++ b/context/app/static/js/components/home/EntityCounts/hooks.ts
@@ -5,11 +5,40 @@ const entityCountsQuery: SearchRequest = {
   size: 0,
   query: {
     bool: {
-      // Only include collections with a DOI in count
-      should: [
-        { bool: { must_not: { term: { 'entity_type.keyword': 'Collection' } } } },
-        { bool: { must: [{ exists: { field: 'doi_url' } }, { exists: { field: 'registered_doi' } }] } },
-      ],
+      // Exclude invalid/new datasets from count
+      // using `must_not` for this allows entities without a mapped status to still be matched
+      must_not: {
+        terms: {
+          'mapped_status.keyword': ['Invalid', 'Error', 'New', 'Processing', 'Submitted'],
+        },
+      },
+      // Nested musts are necessary to form an AND of ORs (i.e. a MUST of SHOULDs)
+      must: {
+        bool: {
+          must: [
+            {
+              // Exclude donors/samples with no associated datasets
+              bool: {
+                should: [
+                  // Either not a donor/sample
+                  { bool: { must_not: { terms: { 'entity_type.keyword': ['Donor', 'Sample'] } } } },
+                  // or has at least one descended dataset
+                  { bool: { must: { exists: { field: 'descendant_counts.entity_type.Dataset' } } } },
+                ],
+              },
+            },
+            {
+              // Only include collections with a DOI in count
+              bool: {
+                should: [
+                  { bool: { must_not: { term: { 'entity_type.keyword': 'Collection' } } } },
+                  { bool: { must: [{ exists: { field: 'doi_url' } }, { exists: { field: 'registered_doi' } }] } },
+                ],
+              },
+            },
+          ],
+        },
+      },
     },
   },
   aggs: {