diff --git a/README.md b/README.md
index 116bce95..d320c1e0 100644
--- a/README.md
+++ b/README.md
@@ -467,6 +467,25 @@ function App() {
 }
 ```
 
+### Creating global styles
+
+Use the `globalCss` API to create global styles:
+
+```js
+import { globalCss } from '@pigment-css/react';
+
+globalCss`
+  body {
+    margin: 0;
+    padding: 0;
+  }
+`;
+```
+
+The `globalCss` function should to be called at the top level of your javascript file, usually from the entry point of the application.
+
+Calling inside a function or a component will not work as expected. Also, the extraction of global styles will always take place regardless of conditional rendering.
+
 ### Theming
 
 Theming is an **optional** feature that lets you reuse the same values, such as colors, spacing, and typography, across your application. It is a plain object of any structure that you can define in your config file.
diff --git a/packages/pigment-css-react/exports/globalCss.js b/packages/pigment-css-react/exports/globalCss.js
new file mode 100644
index 00000000..0cfecb09
--- /dev/null
+++ b/packages/pigment-css-react/exports/globalCss.js
@@ -0,0 +1,5 @@
+Object.defineProperty(exports, '__esModule', {
+  value: true,
+});
+
+exports.default = require('../processors/globalCss').GlobalCssProcessor;
diff --git a/packages/pigment-css-react/src/globalCss.d.ts b/packages/pigment-css-react/src/globalCss.d.ts
new file mode 100644
index 00000000..2a61b4db
--- /dev/null
+++ b/packages/pigment-css-react/src/globalCss.d.ts
@@ -0,0 +1,22 @@
+import type { CSSObjectNoCallback } from './base';
+import type { ThemeArgs } from './theme';
+
+type Primitve = string | null | undefined | boolean | number;
+
+type CssArg = ((themeArgs: ThemeArgs) => CSSObjectNoCallback) | CSSObjectNoCallback;
+type CssFn = (themeArgs: ThemeArgs) => string | number;
+
+interface GlobalCss {
+  /**
+   * @returns {string} The generated css class name to be referenced.
+   */
+  (arg: TemplateStringsArray, ...templateArgs: (Primitve | CssFn)[]): string;
+  /**
+   * @returns {string} The generated css class name to be referenced.
+   */
+  (...arg: CssArg[]): string;
+}
+
+declare const globalCss: GlobalCss;
+
+export default globalCss;
diff --git a/packages/pigment-css-react/src/globalCss.js b/packages/pigment-css-react/src/globalCss.js
new file mode 100644
index 00000000..65e0cfca
--- /dev/null
+++ b/packages/pigment-css-react/src/globalCss.js
@@ -0,0 +1,5 @@
+export default function globalCss() {
+  throw new Error(
+    `${process.env.PACKAGE_NAME}: You were trying to call "globalCss" function without configuring your bundler. Make sure to install the bundler specific plugin and use it. @pigment-css/vite-plugin for Vite integration or @pigment-css/nextjs-plugin for Next.js integration.`,
+  );
+}
diff --git a/packages/pigment-css-react/src/processors/globalCss.ts b/packages/pigment-css-react/src/processors/globalCss.ts
new file mode 100644
index 00000000..3c5244fd
--- /dev/null
+++ b/packages/pigment-css-react/src/processors/globalCss.ts
@@ -0,0 +1,167 @@
+import type { Expression } from '@babel/types';
+import type {
+  CallParam,
+  TemplateParam,
+  Params,
+  TailProcessorParams,
+  ValueCache,
+} from '@wyw-in-js/processor-utils';
+import { serializeStyles, Interpolation } from '@emotion/serialize';
+import { type Replacements, type Rules, ValueType } from '@wyw-in-js/shared';
+import type { CSSInterpolation } from '@emotion/css';
+import { validateParams } from '@wyw-in-js/processor-utils';
+import BaseProcessor from './base-processor';
+import type { IOptions } from './styled';
+import { cache } from '../utils/emotion';
+import { getGlobalSelector } from '../utils/preprocessor';
+
+export type Primitive = string | number | boolean | null | undefined;
+
+export type TemplateCallback = (params: Record<string, unknown> | undefined) => string | number;
+
+export class GlobalCssProcessor extends BaseProcessor {
+  callParam: CallParam | TemplateParam;
+
+  constructor(params: Params, ...args: TailProcessorParams) {
+    super([params[0]], ...args);
+    if (params.length < 2) {
+      throw BaseProcessor.SKIP;
+    }
+    validateParams(
+      params,
+      ['callee', ['call', 'template']],
+      `Invalid use of ${this.tagSource.imported} tag.`,
+    );
+
+    const [, callParams] = params;
+    if (callParams[0] === 'call') {
+      this.dependencies.push(callParams[1]);
+    } else if (callParams[0] === 'template') {
+      callParams[1].forEach((element) => {
+        if ('kind' in element && element.kind !== ValueType.CONST) {
+          this.dependencies.push(element);
+        }
+      });
+    }
+    this.callParam = callParams;
+  }
+
+  build(values: ValueCache) {
+    if (this.artifacts.length > 0) {
+      throw new Error(`MUI: "${this.tagSource.imported}" is already built`);
+    }
+
+    const [callType] = this.callParam;
+
+    if (callType === 'template') {
+      this.handleTemplate(this.callParam, values);
+    } else {
+      this.handleCall(this.callParam, values);
+    }
+  }
+
+  private handleTemplate([, callArgs]: TemplateParam, values: ValueCache) {
+    const templateStrs: string[] = [];
+    // @ts-ignore @TODO - Fix this. No idea how to initialize a Tagged String array.
+    templateStrs.raw = [];
+    const templateExpressions: Primitive[] = [];
+    const { themeArgs } = this.options as IOptions;
+
+    callArgs.forEach((item) => {
+      if ('kind' in item) {
+        switch (item.kind) {
+          case ValueType.FUNCTION: {
+            const value = values.get(item.ex.name) as TemplateCallback;
+            templateExpressions.push(value(themeArgs));
+            break;
+          }
+          case ValueType.CONST:
+            templateExpressions.push(item.value);
+            break;
+          case ValueType.LAZY: {
+            const evaluatedValue = values.get(item.ex.name);
+            if (typeof evaluatedValue === 'function') {
+              templateExpressions.push(evaluatedValue(themeArgs));
+            } else {
+              templateExpressions.push(evaluatedValue as Primitive);
+            }
+            break;
+          }
+          default:
+            break;
+        }
+      } else if (item.type === 'TemplateElement') {
+        templateStrs.push(item.value.cooked as string);
+        // @ts-ignore
+        templateStrs.raw.push(item.value.raw);
+      }
+    });
+    this.generateArtifacts(templateStrs, ...templateExpressions);
+  }
+
+  generateArtifacts(styleObjOrTaggged: CSSInterpolation | string[], ...args: Primitive[]) {
+    const { styles: cssText } = serializeStyles(
+      args.length > 0
+        ? [styleObjOrTaggged as Interpolation<{}>, ...args]
+        : [styleObjOrTaggged as Interpolation<{}>],
+      cache.registered,
+    );
+
+    const rules: Rules = {
+      [this.asSelector]: {
+        className: this.className,
+        cssText,
+        displayName: this.displayName,
+        start: this.location?.start ?? null,
+      },
+    };
+    const sourceMapReplacements: Replacements = [
+      {
+        length: cssText.length,
+        original: {
+          start: {
+            column: this.location?.start.column ?? 0,
+            line: this.location?.start.line ?? 0,
+          },
+          end: {
+            column: this.location?.end.column ?? 0,
+            line: this.location?.end.line ?? 0,
+          },
+        },
+      },
+    ];
+    this.artifacts.push(['css', [rules, sourceMapReplacements]]);
+  }
+
+  private handleCall([, callArg]: CallParam, values: ValueCache) {
+    let styleObj: CSSInterpolation;
+    if (callArg.kind === ValueType.LAZY) {
+      styleObj = values.get(callArg.ex.name) as CSSInterpolation;
+    } else if (callArg.kind === ValueType.FUNCTION) {
+      const { themeArgs } = this.options as IOptions;
+      const value = values.get(callArg.ex.name) as (
+        args: Record<string, unknown> | undefined,
+      ) => CSSInterpolation;
+      styleObj = value(themeArgs);
+    }
+    if (styleObj) {
+      this.generateArtifacts(styleObj);
+    }
+  }
+
+  doEvaltimeReplacement() {
+    this.replacer(this.value, false);
+  }
+
+  doRuntimeReplacement() {
+    this.doEvaltimeReplacement();
+  }
+
+  get asSelector() {
+    return getGlobalSelector(this.className);
+  }
+
+  get value(): Expression {
+    return this.astService.nullLiteral();
+  }
+}
diff --git a/packages/pigment-css-react/src/utils/preprocessor.ts b/packages/pigment-css-react/src/utils/preprocessor.ts
index 48b135fc..816e68d7 100644
--- a/packages/pigment-css-react/src/utils/preprocessor.ts
+++ b/packages/pigment-css-react/src/utils/preprocessor.ts
@@ -34,6 +34,10 @@ const stylis = (css: string, serializerParam = serializer) =>
 
 const defaultGetDirSelector = (dir: 'ltr' | 'rtl') => `[dir=${dir}]`;
 
+export function getGlobalSelector(asSelector: string) {
+  return `$$GLOBAL-${asSelector}`;
+}
+
 export function preprocessor(
   selector: string,
   cssText: string,
@@ -45,14 +49,16 @@ export function preprocessor(
     getDirSelector = defaultGetDirSelector,
   } = options || {};
   let css = '';
-  if (cssText.startsWith('@keyframes')) {
+  const isGlobal = selector.startsWith(getGlobalSelector(''));
+
+  if (!isGlobal && cssText.startsWith('@keyframes')) {
     css += stylis(cssText.replace('@keyframes', `@keyframes ${selector}`));
     return css;
   }
-  css += stylis(`${selector}{${cssText}}`);
+  css += stylis(!isGlobal ? `${selector}{${cssText}}` : cssText);
   if (generateForBothDir) {
     css += stylis(
-      `${getDirSelector(defaultDirection === 'ltr' ? 'rtl' : 'ltr')} ${selector}{${cssText}}`,
+      `${getDirSelector(defaultDirection === 'ltr' ? 'rtl' : 'ltr')} ${!isGlobal ? `${selector}{${cssText}}` : cssText}`,
       serializerRtl,
     );
   }
diff --git a/packages/pigment-css-react/tests/globalCss/fixtures/globalCss-theme.input.js b/packages/pigment-css-react/tests/globalCss/fixtures/globalCss-theme.input.js
new file mode 100644
index 00000000..c1001433
--- /dev/null
+++ b/packages/pigment-css-react/tests/globalCss/fixtures/globalCss-theme.input.js
@@ -0,0 +1,30 @@
+import { globalCss } from '@pigment-css/react';
+
+globalCss`
+* {
+  box-sizing: border-box;
+}
+@font-face {
+  font-family: 'Patrick Hand SC';
+  font-style: normal;
+  font-weight: 400;
+  color: ${({ theme }) => theme.palette.primary.main};
+  src: local('Patrick Hand SC'),
+    local('PatrickHandSC-Regular'),
+    url(https://fonts.gstatic.com/s/patrickhandsc/v4/OYFWCgfCR-7uHIovjUZXsZ71Uis0Qeb9Gqo8IZV7ckE.woff2)
+      format('woff2');
+  unicode-range: U+0100-024f, U+1-1eff,
+    U+20a0-20ab, U+20ad-20cf, U+2c60-2c7f,
+    U+A720-A7FF;
+}
+`;
+
+let inputGlobalStyles = globalCss(({ theme }) => ({
+  '@keyframes mui-auto-fill': { from: { display: 'block', color: 'transparent' } },
+  '@keyframes mui-auto-fill-cancel': {
+    from: { display: 'block', color: theme.palette.primary.main },
+  },
+}));
+if (typeof inputGlobalStyles === 'function') {
+  inputGlobalStyles = inputGlobalStyles();
+}
diff --git a/packages/pigment-css-react/tests/globalCss/fixtures/globalCss-theme.output.css b/packages/pigment-css-react/tests/globalCss/fixtures/globalCss-theme.output.css
new file mode 100644
index 00000000..f6c71611
--- /dev/null
+++ b/packages/pigment-css-react/tests/globalCss/fixtures/globalCss-theme.output.css
@@ -0,0 +1,27 @@
+* {
+  box-sizing: border-box;
+}
+@font-face {
+  font-family: 'Patrick Hand SC';
+  font-style: normal;
+  font-weight: 400;
+  color: red;
+  src:
+    local('Patrick Hand SC'),
+    local('PatrickHandSC-Regular'),
+    url(https://fonts.gstatic.com/s/patrickhandsc/v4/OYFWCgfCR-7uHIovjUZXsZ71Uis0Qeb9Gqo8IZV7ckE.woff2)
+      format('woff2');
+  unicode-range: U+0100-024f, U+1-1eff, U+20a0-20ab, U+20ad-20cf, U+2c60-2c7f, U+A720-A7FF;
+}
+@keyframes mui-auto-fill {
+  from {
+    display: block;
+    color: transparent;
+  }
+}
+@keyframes mui-auto-fill-cancel {
+  from {
+    display: block;
+    color: red;
+  }
+}
diff --git a/packages/pigment-css-react/tests/globalCss/fixtures/globalCss-theme.output.js b/packages/pigment-css-react/tests/globalCss/fixtures/globalCss-theme.output.js
new file mode 100644
index 00000000..59a5426c
--- /dev/null
+++ b/packages/pigment-css-react/tests/globalCss/fixtures/globalCss-theme.output.js
@@ -0,0 +1,5 @@
+null;
+let inputGlobalStyles = null;
+if (typeof inputGlobalStyles === 'function') {
+  inputGlobalStyles = inputGlobalStyles();
+}
diff --git a/packages/pigment-css-react/tests/globalCss/fixtures/globalCss.input.js b/packages/pigment-css-react/tests/globalCss/fixtures/globalCss.input.js
new file mode 100644
index 00000000..966b1041
--- /dev/null
+++ b/packages/pigment-css-react/tests/globalCss/fixtures/globalCss.input.js
@@ -0,0 +1,30 @@
+import { globalCss } from '@pigment-css/react';
+
+const green = 'green';
+
+globalCss`
+* {
+  box-sizing: border-box;
+}
+@font-face {
+  font-family: 'Patrick Hand SC';
+  font-style: normal;
+  font-weight: 400;
+  color: ${green};
+  src: local('Patrick Hand SC'),
+    local('PatrickHandSC-Regular'),
+    url(https://fonts.gstatic.com/s/patrickhandsc/v4/OYFWCgfCR-7uHIovjUZXsZ71Uis0Qeb9Gqo8IZV7ckE.woff2)
+      format('woff2');
+  unicode-range: U+0100-024f, U+1-1eff,
+    U+20a0-20ab, U+20ad-20cf, U+2c60-2c7f,
+    U+A720-A7FF;
+}
+`;
+
+let inputGlobalStyles = globalCss({
+  '@keyframes mui-auto-fill': { from: { display: 'block' } },
+  '@keyframes mui-auto-fill-cancel': { from: { display: 'block' } },
+});
+if (typeof inputGlobalStyles === 'function') {
+  inputGlobalStyles = inputGlobalStyles();
+}
diff --git a/packages/pigment-css-react/tests/globalCss/fixtures/globalCss.output.css b/packages/pigment-css-react/tests/globalCss/fixtures/globalCss.output.css
new file mode 100644
index 00000000..bea96799
--- /dev/null
+++ b/packages/pigment-css-react/tests/globalCss/fixtures/globalCss.output.css
@@ -0,0 +1,25 @@
+* {
+  box-sizing: border-box;
+}
+@font-face {
+  font-family: 'Patrick Hand SC';
+  font-style: normal;
+  font-weight: 400;
+  color: green;
+  src:
+    local('Patrick Hand SC'),
+    local('PatrickHandSC-Regular'),
+    url(https://fonts.gstatic.com/s/patrickhandsc/v4/OYFWCgfCR-7uHIovjUZXsZ71Uis0Qeb9Gqo8IZV7ckE.woff2)
+      format('woff2');
+  unicode-range: U+0100-024f, U+1-1eff, U+20a0-20ab, U+20ad-20cf, U+2c60-2c7f, U+A720-A7FF;
+}
+@keyframes mui-auto-fill {
+  from {
+    display: block;
+  }
+}
+@keyframes mui-auto-fill-cancel {
+  from {
+    display: block;
+  }
+}
diff --git a/packages/pigment-css-react/tests/globalCss/fixtures/globalCss.output.js b/packages/pigment-css-react/tests/globalCss/fixtures/globalCss.output.js
new file mode 100644
index 00000000..59a5426c
--- /dev/null
+++ b/packages/pigment-css-react/tests/globalCss/fixtures/globalCss.output.js
@@ -0,0 +1,5 @@
+null;
+let inputGlobalStyles = null;
+if (typeof inputGlobalStyles === 'function') {
+  inputGlobalStyles = inputGlobalStyles();
+}
diff --git a/packages/pigment-css-react/tests/globalCss/globalCss.test.ts b/packages/pigment-css-react/tests/globalCss/globalCss.test.ts
new file mode 100644
index 00000000..bbca3b00
--- /dev/null
+++ b/packages/pigment-css-react/tests/globalCss/globalCss.test.ts
@@ -0,0 +1,33 @@
+import path from 'node:path';
+import { runTransformation, expect } from '../testUtils';
+
+describe('Pigment CSS - globalCss', () => {
+  it('basics', async () => {
+    const { output, fixture } = await runTransformation(
+      path.join(__dirname, 'fixtures/globalCss.input.js'),
+    );
+
+    expect(output.js).to.equal(fixture.js);
+    expect(output.css).to.equal(fixture.css);
+  });
+
+  it('can access theme', async () => {
+    const { output, fixture } = await runTransformation(
+      path.join(__dirname, 'fixtures/globalCss-theme.input.js'),
+      {
+        themeArgs: {
+          theme: {
+            palette: {
+              primary: {
+                main: 'red',
+              },
+            },
+          },
+        },
+      },
+    );
+
+    expect(output.js).to.equal(fixture.js);
+    expect(output.css).to.equal(fixture.css);
+  });
+});
diff --git a/packages/pigment-css-react/tsup.config.ts b/packages/pigment-css-react/tsup.config.ts
index 5fd52716..3c238b65 100644
--- a/packages/pigment-css-react/tsup.config.ts
+++ b/packages/pigment-css-react/tsup.config.ts
@@ -1,7 +1,15 @@
 import { Options, defineConfig } from 'tsup';
 import config from '../../tsup.config';
 
-const processors = ['styled', 'sx', 'keyframes', 'generateAtomics', 'css', 'createUseThemeProps'];
+const processors = [
+  'styled',
+  'sx',
+  'keyframes',
+  'generateAtomics',
+  'css',
+  'createUseThemeProps',
+  'globalCss',
+];
 const external = ['react', 'react-is', 'prop-types'];
 
 const baseConfig: Options = {