diff --git a/.github/workflows/stress.yml b/.github/workflows/stress.yml
index e8e6f7d16..ce4fd3901 100644
--- a/.github/workflows/stress.yml
+++ b/.github/workflows/stress.yml
@@ -47,7 +47,15 @@ jobs:
       matrix:
         python-version: [3.7]
         go-version: [1.18]
-        suite: ["network-forming", "commissioning", "connectivity", "network-latency", "multicast-performance", "otns-performance", "network-limits"]
+        suite:
+          - "network-forming"
+          - "commissioning"
+          - "connectivity"
+          - "network-latency"
+          - "multicast-performance"
+          - "otns-performance"
+          - "network-limits"
+          - "long-duration"
     runs-on: ubuntu-20.04
     env:
       HOMEBREW_NO_AUTO_UPDATE: 1
diff --git a/pylibs/stress_tests/long_lived.py b/pylibs/stress_tests/long_lived.py
new file mode 100644
index 000000000..8f4be2441
--- /dev/null
+++ b/pylibs/stress_tests/long_lived.py
@@ -0,0 +1,116 @@
+#!/usr/bin/env python3
+#
+# Copyright (c) 2022, The OTNS Authors.
+# All rights reserved.
+#
+# Redistribution and use in source and binary forms, with or without
+# modification, are permitted provided that the following conditions are met:
+# 1. Redistributions of source code must retain the above copyright
+#    notice, this list of conditions and the following disclaimer.
+# 2. Redistributions in binary form must reproduce the above copyright
+#    notice, this list of conditions and the following disclaimer in the
+#    documentation and/or other materials provided with the distribution.
+# 3. Neither the name of the copyright holder nor the
+#    names of its contributors may be used to endorse or promote products
+#    derived from this software without specific prior written permission.
+#
+# THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS"
+# AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE
+# IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE
+# ARE DISCLAIMED. IN NO EVENT SHALL THE COPYRIGHT HOLDER OR CONTRIBUTORS BE
+# LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR
+# CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF
+# SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS
+# INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN
+# CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE)
+# ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE
+# POSSIBILITY OF SUCH DAMAGE.
+#
+# OTNS Long Duration Stress test:
+#   Simulate 4x8 nodes at max speed without injected traffic or failure for 1h, measure the execution (real) time.
+# Topology:
+#   Router 4x8
+# Fault Injections:
+#   None
+# Pass Criteria:
+#   Execution time <= 30s
+#
+import random
+import time
+import os
+
+from BaseStressTest import BaseStressTest
+
+RADIO_RANGE = 200
+XMAX = 300
+YMAX = 300
+
+PACKET_LOSS_RATIO = 0.0
+TOTAL_SIMULATION_TIME = 10 * 86400 * int(os.getenv("STRESS_LEVEL", "1"))
+MOVE_INTERVAL = 3600
+PING_INTERVAL = 3
+PING_DATA_SIZE = 64
+
+
+class LongDurationStressTest(BaseStressTest):
+    SUITE = 'long-duration'
+
+    def __init__(self):
+        super(LongDurationStressTest, self).__init__("Long-Duration stress test",
+                                                  ['Simulation Time', 'Execution Time', 'Speed Up'])
+        self._cur_time = 0
+        self._last_ping_succ_time = {}
+
+    def rand_pos(self):
+        return random.randint(0, XMAX), random.randint(0, YMAX)
+
+    def run(self):
+        ns = self.ns
+        ns.packet_loss_ratio = PACKET_LOSS_RATIO
+
+        router1 = ns.add("router", *self.rand_pos(), radio_range=RADIO_RANGE)
+        router1_addr = self.expect_node_mleid(router1, 10)
+
+        router2 = ns.add("router", *self.rand_pos(), radio_range=RADIO_RANGE)
+        med = ns.add("med", *self.rand_pos(), radio_range=RADIO_RANGE)
+        sed = ns.add("sed", *self.rand_pos(), radio_range=RADIO_RANGE)
+
+        ns.set_poll_period(sed, 60)
+
+        for nodeid in (med, sed):
+            self._last_ping_succ_time[nodeid] = 0
+            ns.ping(nodeid, router1_addr, datasize=PING_DATA_SIZE, count=TOTAL_SIMULATION_TIME // PING_INTERVAL,
+                    interval=PING_INTERVAL)
+
+        t0 = time.time()
+
+        for _ in range(TOTAL_SIMULATION_TIME // MOVE_INTERVAL):
+            self.ns.go(MOVE_INTERVAL)
+            self._cur_time += MOVE_INTERVAL
+
+            self._collect_pings()
+
+            for nodeid in (router1, router2, med, sed):
+                self.ns.move(nodeid, *self.rand_pos())
+
+        duration = time.time() - t0
+
+        self.result.append_row('%ds' % TOTAL_SIMULATION_TIME, '%ds' % duration,
+                               '%d' % (TOTAL_SIMULATION_TIME / duration))
+        self.result.fail_if(TOTAL_SIMULATION_TIME / duration < 3000, "Speed Up < 3000")
+        self.result.fail_if(self._last_ping_succ_time[med] < self._cur_time - 3600, "MED not connected for a long time")
+        self.result.fail_if(self._last_ping_succ_time[sed] < self._cur_time - 3600, "SED not connected for a long time")
+
+    def _collect_pings(self):
+        for srcid, dstaddr, _, delay in self.ns.pings():
+            if delay >= 10000:
+                # ignore failed pings
+                self._ping_fail_count += 1
+                continue
+
+            self._ping_succ_count += 1
+            self._last_ping_succ_time[srcid] = self._cur_time
+
+
+if __name__ == '__main__':
+    LongDurationStressTest().run()
diff --git a/script/test b/script/test
index cf56ecf63..bc7d07a6f 100755
--- a/script/test
+++ b/script/test
@@ -99,6 +99,7 @@ build_openthread()
             "-DOT_SERVICE=ON"
             "-DOT_COAP=ON"
             "-DOT_THREAD_VERSION=${THREAD_VERSION:-1.2}"
+            "-DOT_UPTIME=ON"
         )
 
         local COVERAGE=${COVERAGE:-0}