diff --git a/.Rprofile b/.Rprofile
index 63eee448..77ae067e 100644
--- a/.Rprofile
+++ b/.Rprofile
@@ -1,16 +1,15 @@
 # Set renv profile base on R version.
-renv_profile <- paste(R.version$major, substr(R.version$minor, 1, 1), sep = ".")
-if (file.exists("./renv/profile")) {
-   message("Using renv profile from `renv/profile` file.")
-} else if (renv_profile %in% c("4.1", "4.2", "4.3")) {
-  message("Set renv profile to `", renv_profile, "`")
-  Sys.setenv("RENV_PROFILE" = renv_profile)
+if ((Sys.getenv("GITHUB_ACTIONS") == "") && (Sys.getenv("DOCKER_CONTAINER_CONTEXT") == "")) {
+  renv_profile <- paste(R.version$major, substr(R.version$minor, 1, 1), sep = ".")
+  if (file.exists("./renv/profile")) {
+    message("Using renv profile from `renv/profile` file.")
+  } else if (renv_profile %in% c("4.1", "4.2", "4.3")) {
+    message("Set renv profile to `", renv_profile, "`")
+    Sys.setenv("RENV_PROFILE" = renv_profile)
+  } else {
+    message("This repository do not contains the renv profile for your R version.")
+  }
+  source("renv/activate.R")
 } else {
-  message("This repository do not contains the renv profile for your R version.")
-}
-
-if ((Sys.getenv("GITHUB_ACTIONS") != "") || (Sys.getenv("DOCKER_CONTAINER_CONTEXT") != "")) {
   options(repos = c(CRAN = "https://cran.rstudio.com"))
-  Sys.setenv(RENV_AUTOLOADER_ENABLED=FALSE)
 }
-source("renv/activate.R")
diff --git a/.devcontainer/4.1/devcontainer.json b/.devcontainer/4.1/devcontainer.json
new file mode 100644
index 00000000..a0415f8b
--- /dev/null
+++ b/.devcontainer/4.1/devcontainer.json
@@ -0,0 +1,77 @@
+{
+	// https://containers.dev/implementors/json_reference/
+	"name": "Admiral R-4.1 (RStudio) container",
+	"image": "ghcr.io/pharmaverse/admiralci-4.1:latest",
+	// Install Dev Container Features. More info: https://containers.dev/features
+	"containerEnv": {
+		"ROOT": "true",
+		"PASSWORD": "rstudio",
+		"DISABLE_AUTH": "true"
+	},
+	"features": {
+		"ghcr.io/rocker-org/devcontainer-features/r-rig:1": {
+			"version": "none",
+			"vscodeRSupport": "full",
+			"installRadian": true,
+			"installVscDebugger": true
+		},
+		"ghcr.io/rocker-org/devcontainer-features/renv-cache:latest": {},
+		"ghcr.io/devcontainers/features/common-utils:2": {
+			"installZsh": true,
+			"configureZshAsDefaultShell": true,
+			"installOhMyZsh": true,
+			"username": "rstudio",
+			"upgradePackages": false
+				
+		},
+		"ghcr.io/mikaello/devcontainer-features/modern-shell-utils:1": {}
+	},
+	"init": true,
+	"overrideCommand": false,
+	
+	"postCreateCommand": {
+		"renv": "R -q -e 'renv::activate(profile = \"4.1\"); renv::restore(); staged.dependencies::install_deps(staged.dependencies::dependency_table(project = \".\", verbose = 1), verbose = 1);'",
+		"rstudio": "jq --arg folder \"$(pwd)/\" '. + { \"initial_working_directory\": $folder }' .devcontainer/rstudio-prefs.json > ~/.config/rstudio/rstudio-prefs.json"
+	},
+
+	"customizations": {
+		"vscode": {
+			"settings": {
+				"r.rterm.linux": "/usr/local/bin/radian",
+				"r.bracketedPaste": true,
+				"editor.bracketPairColorization.enabled": true, 
+				"editor.guides.bracketPairs": "active"
+			},
+			"extensions": [
+				"vsls-contrib.codetour",
+				"GitHub.copilot",
+				"GitHub.copilot-chat",
+				// R extensions
+				"ikuyadeu.r",
+				"REditorSupport.r-lsp",
+				// Extra extension
+				"streetsidesoftware.code-spell-checker",
+				"eamodio.gitlens",
+				"cweijan.vscode-office",
+				"donjayamanne.githistory",
+				"GitHub.vscode-github-actions",
+				"GitHub.vscode-pull-request-github",
+				"GitHub.remotehub",
+				"alefragnani.Bookmarks",
+				"vscode-icons-team.vscode-icons"
+			]
+		}
+	},
+
+	// RStudio ports
+	"forwardPorts": [8787],
+	"portsAttributes": {
+		"8787": {
+			"label": "Rstudio",
+			"requireLocalPort": true,
+			"onAutoForward": "ignore"
+		}
+	},
+	// Uncomment to connect as root instead. More info: https://aka.ms/dev-containers-non-root
+	"remoteUser": "rstudio"
+}
diff --git a/.devcontainer/4.2/devcontainer.json b/.devcontainer/4.2/devcontainer.json
new file mode 100644
index 00000000..493aba1a
--- /dev/null
+++ b/.devcontainer/4.2/devcontainer.json
@@ -0,0 +1,77 @@
+{
+	// https://containers.dev/implementors/json_reference/
+	"name": "Admiral R-4.2 (RStudio) container",
+	"image": "ghcr.io/pharmaverse/admiralci-4.2:latest",
+	// Install Dev Container Features. More info: https://containers.dev/features
+	"containerEnv": {
+		"ROOT": "true",
+		"PASSWORD": "rstudio",
+		"DISABLE_AUTH": "true"
+	},
+	"features": {
+		"ghcr.io/rocker-org/devcontainer-features/r-rig:1": {
+			"version": "none",
+			"vscodeRSupport": "full",
+			"installRadian": true,
+			"installVscDebugger": true
+		},
+		"ghcr.io/rocker-org/devcontainer-features/renv-cache:latest": {},
+		"ghcr.io/devcontainers/features/common-utils:2": {
+			"installZsh": true,
+			"configureZshAsDefaultShell": true,
+			"installOhMyZsh": true,
+			"username": "rstudio",
+			"upgradePackages": false
+				
+		},
+		"ghcr.io/mikaello/devcontainer-features/modern-shell-utils:1": {}
+	},
+	"init": true,
+	"overrideCommand": false,
+	
+	"postCreateCommand": {
+		"renv": "R -q -e 'renv::activate(profile = \"4.2\"); renv::restore(); staged.dependencies::install_deps(staged.dependencies::dependency_table(project = \".\", verbose = 1), verbose = 1);'",
+		"rstudio": "jq --arg folder \"$(pwd)/\" '. + { \"initial_working_directory\": $folder }' .devcontainer/rstudio-prefs.json > ~/.config/rstudio/rstudio-prefs.json"
+	},
+
+	"customizations": {
+		"vscode": {
+			"settings": {
+				"r.rterm.linux": "/usr/local/bin/radian",
+				"r.bracketedPaste": true,
+				"editor.bracketPairColorization.enabled": true, 
+				"editor.guides.bracketPairs": "active"
+			},
+			"extensions": [
+				"vsls-contrib.codetour",
+				"GitHub.copilot",
+				"GitHub.copilot-chat",
+				// R extensions
+				"ikuyadeu.r",
+				"REditorSupport.r-lsp",
+				// Extra extension
+				"streetsidesoftware.code-spell-checker",
+				"eamodio.gitlens",
+				"cweijan.vscode-office",
+				"donjayamanne.githistory",
+				"GitHub.vscode-github-actions",
+				"GitHub.vscode-pull-request-github",
+				"GitHub.remotehub",
+				"alefragnani.Bookmarks",
+				"vscode-icons-team.vscode-icons"
+			]
+		}
+	},
+
+	// RStudio ports
+	"forwardPorts": [8787],
+	"portsAttributes": {
+		"8787": {
+			"label": "Rstudio",
+			"requireLocalPort": true,
+			"onAutoForward": "ignore"
+		}
+	},
+	// Uncomment to connect as root instead. More info: https://aka.ms/dev-containers-non-root
+	"remoteUser": "rstudio"
+}
diff --git a/.devcontainer/devcontainer.json b/.devcontainer/devcontainer.json
new file mode 100644
index 00000000..47a8a0f6
--- /dev/null
+++ b/.devcontainer/devcontainer.json
@@ -0,0 +1,77 @@
+{
+	// https://containers.dev/implementors/json_reference/
+	"name": "Admiral R-4.3 (RStudio) container",
+	"image": "ghcr.io/pharmaverse/admiralci-4.3:latest",
+	// Install Dev Container Features. More info: https://containers.dev/features
+	"containerEnv": {
+		"ROOT": "true",
+		"PASSWORD": "rstudio",
+		"DISABLE_AUTH": "true",
+        "DOCKER_CONTAINER_CONTEXT": ""
+	},
+	"features": {
+		"ghcr.io/rocker-org/devcontainer-features/r-rig:1": {
+			"version": "none",
+			"vscodeRSupport": "full",
+			"installRadian": true,
+			"installVscDebugger": true
+		},
+		"ghcr.io/rocker-org/devcontainer-features/renv-cache:latest": {},
+		"ghcr.io/devcontainers/features/common-utils:2": {
+			"installZsh": true,
+			"configureZshAsDefaultShell": true,
+			"installOhMyZsh": true,
+			"username": "rstudio",
+			"upgradePackages": false
+		},
+		"ghcr.io/mikaello/devcontainer-features/modern-shell-utils:1": {}
+	},
+	"init": true,
+	"overrideCommand": false,
+	
+	"postCreateCommand": {
+		"renv": "R -q -e 'renv::activate(profile = \"4.3\"); renv::restore(); staged.dependencies::install_deps(staged.dependencies::dependency_table(project = \".\", verbose = 1), verbose = 1);'",
+		"rstudio": "jq --arg folder \"$(pwd)/\" '. + { \"initial_working_directory\": $folder }' .devcontainer/rstudio-prefs.json > ~/.config/rstudio/rstudio-prefs.json"
+	},
+
+	"customizations": {
+		"vscode": {
+			"settings": {
+				"r.rterm.linux": "/usr/local/bin/radian",
+				"r.bracketedPaste": true,
+				"editor.bracketPairColorization.enabled": true, 
+				"editor.guides.bracketPairs": "active"
+			},
+			"extensions": [
+				"vsls-contrib.codetour",
+				"GitHub.copilot",
+				"GitHub.copilot-chat",
+				// R extensions
+				"ikuyadeu.r",
+				"REditorSupport.r-lsp",
+				// Extra extension
+				"streetsidesoftware.code-spell-checker",
+				"eamodio.gitlens",
+				"cweijan.vscode-office",
+				"donjayamanne.githistory",
+				"GitHub.vscode-github-actions",
+				"GitHub.vscode-pull-request-github",
+				"GitHub.remotehub",
+				"alefragnani.Bookmarks",
+				"vscode-icons-team.vscode-icons"
+			]
+		}
+	},
+
+	// RStudio ports
+	"forwardPorts": [8787],
+	"portsAttributes": {
+		"8787": {
+			"label": "Rstudio",
+			"requireLocalPort": true,
+			"onAutoForward": "ignore"
+		}
+	},
+	// Uncomment to connect as root instead. More info: https://aka.ms/dev-containers-non-root
+	"remoteUser": "rstudio"
+}
diff --git a/.devcontainer/rstudio-prefs.json b/.devcontainer/rstudio-prefs.json
new file mode 100644
index 00000000..2d5cce84
--- /dev/null
+++ b/.devcontainer/rstudio-prefs.json
@@ -0,0 +1,8 @@
+{
+	"save_workspace": "never",
+	"always_save_history": false,
+	"reuse_sessions_for_project_links": true,
+	"posix_terminal_shell": "bash",
+	"initial_working_directory": "/workspaces",
+	"show_hidden_files": true
+}