diff --git a/404.html b/404.html
index 985539ca..69d3aeda 100644
--- a/404.html
+++ b/404.html
@@ -31,7 +31,7 @@
     
     <a class="navbar-brand me-2" href="https://pharmaverse.github.io/admiralophtha/index.html">admiralophtha</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0.9002</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -64,18 +64,6 @@
 </form>
 
       <ul class="navbar-nav">
-<li class="nav-item">
-  <a class="external-link nav-link" href="https://app.slack.com/client/T028PB489D3/C02M8KN8269" aria-label="Slack">
-    <span class="fa fa-slack"></span>
-     
-  </a>
-</li>
-<li class="nav-item">
-  <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha/issues/new/choose" aria-label="New Issue">
-    <span class="fa fa-bug"></span>
-     
-  </a>
-</li>
 <li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha" aria-label="github">
     <span class="fab fa fab fa-github fa-lg"></span>
diff --git a/LICENSE.html b/LICENSE.html
index 004f7802..7388647e 100644
--- a/LICENSE.html
+++ b/LICENSE.html
@@ -10,7 +10,7 @@
     
     <a class="navbar-brand me-2" href="index.html">admiralophtha</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0.9002</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -40,18 +40,6 @@
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
       <ul class="navbar-nav"><li class="nav-item">
-  <a class="external-link nav-link" href="https://app.slack.com/client/T028PB489D3/C02M8KN8269" aria-label="Slack">
-    <span class="fa fa-slack"></span>
-     
-  </a>
-</li>
-<li class="nav-item">
-  <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha/issues/new/choose" aria-label="New Issue">
-    <span class="fa fa-bug"></span>
-     
-  </a>
-</li>
-<li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha" aria-label="github">
     <span class="fab fa fab fa-github fa-lg"></span>
      
diff --git a/articles/adbcva.html b/articles/adbcva.html
index 6e3e123c..d6d851fb 100644
--- a/articles/adbcva.html
+++ b/articles/adbcva.html
@@ -33,7 +33,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">admiralophtha</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0.9002</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -66,18 +66,6 @@
 </form>
 
       <ul class="navbar-nav">
-<li class="nav-item">
-  <a class="external-link nav-link" href="https://app.slack.com/client/T028PB489D3/C02M8KN8269" aria-label="Slack">
-    <span class="fa fa-slack"></span>
-     
-  </a>
-</li>
-<li class="nav-item">
-  <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha/issues/new/choose" aria-label="New Issue">
-    <span class="fa fa-bug"></span>
-     
-  </a>
-</li>
 <li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha" aria-label="github">
     <span class="fab fa fab fa-github fa-lg"></span>
@@ -250,24 +238,24 @@ <h3 id="logmar">Deriving LogMAR Score Parameters<a class="anchor" aria-label="an
 <div class="sourceCode" id="cb6"><pre class="downlit sourceCode r">
 <code class="sourceCode R"><span><span class="va">adbcva</span> <span class="op">&lt;-</span> <span class="va">adbcva</span> <span class="op"><a href="https://magrittr.tidyverse.org/reference/pipe.html" class="external-link">%&gt;%</a></span></span>
 <span>  <span class="fu"><a href="https://pharmaverse.github.io/admiral/reference/derive_param_computed.html" class="external-link">derive_param_computed</a></span><span class="op">(</span></span>
-<span>    by_vars <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fu"><a href="https://rlang.r-lib.org/reference/defusing-advanced.html" class="external-link">exprs</a></span><span class="op">(</span><span class="va">STUDYID</span>, <span class="va">USUBJID</span>, <span class="va">VISIT</span>, <span class="va">VISITNUM</span>, <span class="va">OEDY</span>, <span class="va">OEDTC</span>, <span class="va">AFEYE</span><span class="op">)</span>, <span class="va">adsl_vars</span><span class="op">)</span>,</span>
+<span>    by_vars <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fu"><a href="https://rlang.r-lib.org/reference/defusing-advanced.html" class="external-link">exprs</a></span><span class="op">(</span><span class="va">STUDYID</span>, <span class="va">USUBJID</span>, <span class="va">VISIT</span>, <span class="va">VISITNUM</span>, <span class="va">OEDY</span>, <span class="va">OEDTC</span><span class="op">)</span>, <span class="va">adsl_vars</span><span class="op">)</span>,</span>
 <span>    parameters <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"SBCVA"</span><span class="op">)</span>,</span>
+<span>    analysis_value <span class="op">=</span> <span class="fu"><a href="../reference/convert_etdrs_to_logmar.html">convert_etdrs_to_logmar</a></span><span class="op">(</span><span class="va">AVAL.SBCVA</span><span class="op">)</span>,</span>
 <span>    set_values_to <span class="op">=</span> <span class="fu"><a href="https://rlang.r-lib.org/reference/defusing-advanced.html" class="external-link">exprs</a></span><span class="op">(</span></span>
-<span>      AVAL <span class="op">=</span> <span class="fu"><a href="../reference/convert_etdrs_to_logmar.html">convert_etdrs_to_logmar</a></span><span class="op">(</span><span class="va">AVAL.SBCVA</span><span class="op">)</span>,</span>
 <span>      PARAMCD <span class="op">=</span> <span class="st">"SBCVALOG"</span>,</span>
 <span>      PARAM <span class="op">=</span> <span class="st">"Study Eye Visual Acuity LogMAR Score"</span>,</span>
-<span>      DTYPE <span class="op">=</span> <span class="cn">NA_character_</span>,</span>
+<span>      DTYPE <span class="op">=</span> <span class="st">"DERIVED"</span>,</span>
 <span>      AVALU <span class="op">=</span> <span class="st">"LogMAR"</span></span>
 <span>    <span class="op">)</span></span>
 <span>  <span class="op">)</span> <span class="op"><a href="https://magrittr.tidyverse.org/reference/pipe.html" class="external-link">%&gt;%</a></span></span>
 <span>  <span class="fu"><a href="https://pharmaverse.github.io/admiral/reference/derive_param_computed.html" class="external-link">derive_param_computed</a></span><span class="op">(</span></span>
-<span>    by_vars <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fu"><a href="https://rlang.r-lib.org/reference/defusing-advanced.html" class="external-link">exprs</a></span><span class="op">(</span><span class="va">STUDYID</span>, <span class="va">USUBJID</span>, <span class="va">VISIT</span>, <span class="va">OEDY</span>, <span class="va">OEDTC</span>, <span class="va">AFEYE</span><span class="op">)</span>, <span class="va">adsl_vars</span><span class="op">)</span>,</span>
+<span>    by_vars <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="fu"><a href="https://rlang.r-lib.org/reference/defusing-advanced.html" class="external-link">exprs</a></span><span class="op">(</span><span class="va">STUDYID</span>, <span class="va">USUBJID</span>, <span class="va">VISIT</span>, <span class="va">OEDY</span>, <span class="va">OEDTC</span><span class="op">)</span>, <span class="va">adsl_vars</span><span class="op">)</span>,</span>
 <span>    parameters <span class="op">=</span> <span class="fu"><a href="https://rdrr.io/r/base/c.html" class="external-link">c</a></span><span class="op">(</span><span class="st">"FBCVA"</span><span class="op">)</span>,</span>
+<span>    analysis_value <span class="op">=</span> <span class="fu"><a href="../reference/convert_etdrs_to_logmar.html">convert_etdrs_to_logmar</a></span><span class="op">(</span><span class="va">AVAL.FBCVA</span><span class="op">)</span>,</span>
 <span>    set_values_to <span class="op">=</span> <span class="fu"><a href="https://rlang.r-lib.org/reference/defusing-advanced.html" class="external-link">exprs</a></span><span class="op">(</span></span>
-<span>      AVAL <span class="op">=</span> <span class="fu"><a href="../reference/convert_etdrs_to_logmar.html">convert_etdrs_to_logmar</a></span><span class="op">(</span><span class="va">AVAL.FBCVA</span><span class="op">)</span>,</span>
 <span>      PARAMCD <span class="op">=</span> <span class="st">"FBCVALOG"</span>,</span>
 <span>      PARAM <span class="op">=</span> <span class="st">"Fellow Eye Visual Acuity LogMAR Score"</span>,</span>
-<span>      DTYPE <span class="op">=</span> <span class="cn">NA_character_</span>,</span>
+<span>      DTYPE <span class="op">=</span> <span class="st">"DERIVED"</span>,</span>
 <span>      AVALU <span class="op">=</span> <span class="st">"LogMAR"</span></span>
 <span>    <span class="op">)</span></span>
 <span>  <span class="op">)</span> <span class="op"><a href="https://magrittr.tidyverse.org/reference/pipe.html" class="external-link">%&gt;%</a></span></span>
@@ -277,7 +265,13 @@ <h3 id="logmar">Deriving LogMAR Score Parameters<a class="anchor" aria-label="an
 <span>    dtc <span class="op">=</span> <span class="va">OEDTC</span>,</span>
 <span>    flag_imputation <span class="op">=</span> <span class="st">"none"</span></span>
 <span>  <span class="op">)</span> <span class="op"><a href="https://magrittr.tidyverse.org/reference/pipe.html" class="external-link">%&gt;%</a></span></span>
-<span>  <span class="fu"><a href="https://pharmaverse.github.io/admiral/reference/derive_vars_dy.html" class="external-link">derive_vars_dy</a></span><span class="op">(</span>reference_date <span class="op">=</span> <span class="va">TRTSDT</span>, source_vars <span class="op">=</span> <span class="fu"><a href="https://rlang.r-lib.org/reference/defusing-advanced.html" class="external-link">exprs</a></span><span class="op">(</span><span class="va">ADT</span><span class="op">)</span><span class="op">)</span></span></code></pre></div>
+<span>  <span class="fu"><a href="https://pharmaverse.github.io/admiral/reference/derive_vars_dy.html" class="external-link">derive_vars_dy</a></span><span class="op">(</span>reference_date <span class="op">=</span> <span class="va">TRTSDT</span>, source_vars <span class="op">=</span> <span class="fu"><a href="https://rlang.r-lib.org/reference/defusing-advanced.html" class="external-link">exprs</a></span><span class="op">(</span><span class="va">ADT</span><span class="op">)</span><span class="op">)</span></span>
+<span><span class="co">#&gt; Warning: The `analysis_value` argument of `derive_param_computed()` is deprecated as of</span></span>
+<span><span class="co">#&gt; admiral 0.12.0.</span></span>
+<span><span class="co">#&gt; <span style="color: #00BBBB;">ℹ</span> Please use the `set_values_to` argument instead.</span></span>
+<span><span class="co">#&gt; <span style="color: #555555;">This warning is displayed once every 8 hours.</span></span></span>
+<span><span class="co">#&gt; <span style="color: #555555;">Call `lifecycle::last_lifecycle_warnings()` to see where this warning was</span></span></span>
+<span><span class="co">#&gt; <span style="color: #555555;">generated.</span></span></span></code></pre></div>
 <p>Importantly, the above calls to <code><a href="https://pharmaverse.github.io/admiral/reference/derive_param_computed.html" class="external-link">derive_param_computed()</a></code>
 list the SDTM variables <code>VISIT</code>, <code>VISITNUM</code>,
 <code>OEDY</code> and <code>OEDTC</code> as <code>by_vars</code> for the
@@ -397,8 +391,8 @@ <h3 id="avalcats">Deriving Analysis Value Categories for Snellen Scores<a class=
 <span>  <span class="op">)</span></span></code></pre></div>
 <p>The resulting output is shown below (limited to the first patient
 only):</p>
-<div id="htmlwidget-d21ab1818f577211e6a6" style="width:auto;height:auto;" class="datatables html-widget "></div>
-<script type="application/json" data-for="htmlwidget-d21ab1818f577211e6a6">{"x":{"filter":"top","vertical":false,"filterHTML":"<tr>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;CDISCPILOT01&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;OE&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;01-701-1015&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"integer\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"7\" data-max=\"72\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;BEST CORRECTED VISUAL ACUITY&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;OVERALL EVALUATION&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;2013-12-26&quot;,&quot;2014-01-02&quot;,&quot;2014-01-30&quot;,&quot;2014-02-12&quot;,&quot;2014-03-05&quot;,&quot;2014-03-26&quot;,&quot;2014-05-07&quot;,&quot;2014-05-21&quot;,&quot;2014-06-18&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;BASELINE&quot;,&quot;SCREENING 1&quot;,&quot;WEEK 12&quot;,&quot;WEEK 16&quot;,&quot;WEEK 20&quot;,&quot;WEEK 24&quot;,&quot;WEEK 4&quot;,&quot;WEEK 6&quot;,&quot;WEEK 8&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"number\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"1\" data-max=\"12\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"number\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"-7\" data-max=\"168\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"number\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"2\" data-max=\"97\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;2&quot;,&quot;24&quot;,&quot;31&quot;,&quot;35&quot;,&quot;41&quot;,&quot;44&quot;,&quot;52&quot;,&quot;62&quot;,&quot;64&quot;,&quot;69&quot;,&quot;77&quot;,&quot;82&quot;,&quot;84&quot;,&quot;88&quot;,&quot;92&quot;,&quot;97&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;2&quot;,&quot;24&quot;,&quot;31&quot;,&quot;35&quot;,&quot;41&quot;,&quot;44&quot;,&quot;52&quot;,&quot;62&quot;,&quot;64&quot;,&quot;69&quot;,&quot;77&quot;,&quot;82&quot;,&quot;84&quot;,&quot;88&quot;,&quot;92&quot;,&quot;97&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;Visual Acuity Score&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;VACSCORE&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;LEFT&quot;,&quot;RIGHT&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;EYE&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"number\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"-7\" data-max=\"168\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;ETDRS EYE CHART&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"logical\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;true&quot;,&quot;false&quot;,&quot;na&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"date\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"0\" data-max=\"1\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"date\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"0\" data-max=\"1\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;Placebo&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;Placebo&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;RIGHT&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"number\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"-0.24\" data-max=\"97\" data-scale=\"15\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;letters&quot;,&quot;LogMAR&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;DERIVED&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;Fellow Eye&quot;,&quot;Study Eye&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;Fellow Eye Visual Acuity LogMAR Score&quot;,&quot;Fellow Eye Visual Acuity Score&quot;,&quot;Study Eye Visual Acuity LogMAR Score&quot;,&quot;Study Eye Visual Acuity Score&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;FBCVA&quot;,&quot;FBCVALOG&quot;,&quot;SBCVA&quot;,&quot;SBCVALOG&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;-0.0600000000000001&quot;,&quot;-0.14&quot;,&quot;-0.24&quot;,&quot;0.02&quot;,&quot;0.0599999999999998&quot;,&quot;0.16&quot;,&quot;0.32&quot;,&quot;0.42&quot;,&quot;0.46&quot;,&quot;0.66&quot;,&quot;0.82&quot;,&quot;0.88&quot;,&quot;1&quot;,&quot;1.08&quot;,&quot;1.22&quot;,&quot;1.66&quot;,&quot;2&quot;,&quot;24&quot;,&quot;31&quot;,&quot;35&quot;,&quot;41&quot;,&quot;44&quot;,&quot;52&quot;,&quot;62&quot;,&quot;64&quot;,&quot;69&quot;,&quot;77&quot;,&quot;82&quot;,&quot;84&quot;,&quot;88&quot;,&quot;92&quot;,&quot;97&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"date\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"1.388016e+12\" data-max=\"1403049600000\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"number\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"-7\" data-max=\"168\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"logical\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;true&quot;,&quot;false&quot;,&quot;na&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;Baseline&quot;,&quot;Screening&quot;,&quot;Week 12&quot;,&quot;Week 16&quot;,&quot;Week 20&quot;,&quot;Week 24&quot;,&quot;Week 4&quot;,&quot;Week 6&quot;,&quot;Week 8&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"number\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"1\" data-max=\"12\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;LAST&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;Y&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;Y&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;Y&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;Y&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;Y&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"number\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"0.159999999999999\" data-max=\"77\" data-scale=\"15\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;0.16&quot;,&quot;1&quot;,&quot;35&quot;,&quot;77&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"number\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"-75\" data-max=\"62\" data-scale=\"15\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"number\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"-187.5\" data-max=\"937.500000000001\" data-scale=\"15\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"integer\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"1\" data-max=\"36\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;1015&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;2014-01-02&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;2014-07-02&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;2014-01-02&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;2014-07-02&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;2014-07-02T11:45&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;701&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"number\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"0\" data-max=\"1\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;YEARS&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;F&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;WHITE&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;HISPANIC OR LATINO&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;Pbo&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;Placebo&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;Pbo&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;Placebo&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;USA&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;2013-12-26&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"number\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"0\" data-max=\"1\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"time\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"0\" data-max=\"1\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;H&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"time\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"0\" data-max=\"1\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;H&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"number\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"0\" data-max=\"1\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"date\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"0\" data-max=\"1\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"date\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"0\" data-max=\"1\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;COMPLETED&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"date\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"0\" data-max=\"1\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"date\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"0\" data-max=\"1\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"date\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"0\" data-max=\"1\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"number\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"0\" data-max=\"1\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"number\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"0\" data-max=\"1\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"date\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"0\" data-max=\"1\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;&lt;18&quot;,&quot;18-64&quot;,&quot;&gt;=65&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;Y&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;White&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;NA&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input 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style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"number\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"2\" data-max=\"97\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;2&quot;,&quot;24&quot;,&quot;31&quot;,&quot;35&quot;,&quot;41&quot;,&quot;44&quot;,&quot;52&quot;,&quot;62&quot;,&quot;64&quot;,&quot;69&quot;,&quot;77&quot;,&quot;82&quot;,&quot;84&quot;,&quot;88&quot;,&quot;92&quot;,&quot;97&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;2&quot;,&quot;24&quot;,&quot;31&quot;,&quot;35&quot;,&quot;41&quot;,&quot;44&quot;,&quot;52&quot;,&quot;62&quot;,&quot;64&quot;,&quot;69&quot;,&quot;77&quot;,&quot;82&quot;,&quot;84&quot;,&quot;88&quot;,&quot;92&quot;,&quot;97&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;Visual Acuity Score&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;VACSCORE&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;LEFT&quot;,&quot;RIGHT&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;EYE&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"number\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"-7\" data-max=\"168\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;ETDRS EYE CHART&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"logical\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;true&quot;,&quot;false&quot;,&quot;na&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"date\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"0\" data-max=\"1\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"date\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"0\" data-max=\"1\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;Placebo&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;Placebo&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;RIGHT&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"number\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"-0.24\" data-max=\"97\" data-scale=\"15\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;letters&quot;,&quot;LogMAR&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;DERIVED&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;Fellow Eye&quot;,&quot;Study Eye&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;Fellow Eye Visual Acuity LogMAR Score&quot;,&quot;Fellow Eye Visual Acuity Score&quot;,&quot;Study Eye Visual Acuity LogMAR Score&quot;,&quot;Study Eye Visual Acuity Score&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;FBCVA&quot;,&quot;FBCVALOG&quot;,&quot;SBCVA&quot;,&quot;SBCVALOG&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;-0.0600000000000001&quot;,&quot;-0.14&quot;,&quot;-0.24&quot;,&quot;0.02&quot;,&quot;0.0599999999999998&quot;,&quot;0.16&quot;,&quot;0.32&quot;,&quot;0.42&quot;,&quot;0.46&quot;,&quot;0.66&quot;,&quot;0.82&quot;,&quot;0.88&quot;,&quot;1&quot;,&quot;1.08&quot;,&quot;1.22&quot;,&quot;1.66&quot;,&quot;2&quot;,&quot;24&quot;,&quot;31&quot;,&quot;35&quot;,&quot;41&quot;,&quot;44&quot;,&quot;52&quot;,&quot;62&quot;,&quot;64&quot;,&quot;69&quot;,&quot;77&quot;,&quot;82&quot;,&quot;84&quot;,&quot;88&quot;,&quot;92&quot;,&quot;97&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"date\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"1.388016e+12\" data-max=\"1403049600000\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"number\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"-7\" data-max=\"168\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"logical\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;true&quot;,&quot;false&quot;,&quot;na&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;Baseline&quot;,&quot;Screening&quot;,&quot;Week 12&quot;,&quot;Week 16&quot;,&quot;Week 20&quot;,&quot;Week 24&quot;,&quot;Week 4&quot;,&quot;Week 6&quot;,&quot;Week 8&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"number\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"1\" data-max=\"12\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;LAST&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;Y&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;Y&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;Y&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;Y&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;Y&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"number\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"0.159999999999999\" data-max=\"77\" data-scale=\"15\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;0.16&quot;,&quot;1&quot;,&quot;35&quot;,&quot;77&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"number\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"-75\" data-max=\"62\" data-scale=\"15\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"number\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"-187.5\" data-max=\"937.500000000001\" data-scale=\"15\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"integer\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"1\" data-max=\"36\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;1015&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;2014-01-02&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;2014-07-02&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;2014-01-02&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;2014-07-02&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;2014-07-02T11:45&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;701&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"number\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"0\" data-max=\"1\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;YEARS&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;F&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;WHITE&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;HISPANIC OR LATINO&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;Pbo&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;Placebo&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;Pbo&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;Placebo&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;USA&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;2013-12-26&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"number\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"0\" data-max=\"1\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"time\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"0\" data-max=\"1\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;H&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"time\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"0\" data-max=\"1\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;H&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"number\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"0\" data-max=\"1\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"date\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"0\" data-max=\"1\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"date\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"0\" data-max=\"1\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;COMPLETED&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"date\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"0\" data-max=\"1\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"date\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"0\" data-max=\"1\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"date\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"0\" data-max=\"1\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"number\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"0\" data-max=\"1\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"number\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"0\" data-max=\"1\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"date\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"0\" data-max=\"1\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;&lt;18&quot;,&quot;18-64&quot;,&quot;&gt;=65&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;Y&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;White&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;NA&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\" disabled=\"\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[]\"><\/select>\n    <\/div>\n  <\/td>\n  <td data-type=\"number\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"12\" data-max=\"1000\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;&lt; 20/800&quot;,&quot;20/100&quot;,&quot;20/12&quot;,&quot;20/125&quot;,&quot;20/16&quot;,&quot;20/160&quot;,&quot;20/20&quot;,&quot;20/200&quot;,&quot;20/25&quot;,&quot;20/250&quot;,&quot;20/32&quot;,&quot;20/320&quot;,&quot;20/40&quot;,&quot;20/50&quot;,&quot;20/63&quot;]\"><\/select>\n    <\/div>\n  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<th>AVAL<\/th>\n      <th>AVALU<\/th>\n      <th>DTYPE<\/th>\n      <th>AFEYE<\/th>\n      <th>PARAM<\/th>\n      <th>PARAMCD<\/th>\n      <th>AVALC<\/th>\n      <th>ADT<\/th>\n      <th>ADY<\/th>\n      <th>ATPTN<\/th>\n      <th>ATPT<\/th>\n      <th>AVISIT<\/th>\n      <th>AVISITN<\/th>\n      <th>BASETYPE<\/th>\n      <th>ONTRTFL<\/th>\n      <th>ABLFL<\/th>\n      <th>ANL01FL<\/th>\n      <th>ANL02FL<\/th>\n      <th>WORS01FL<\/th>\n      <th>BASE<\/th>\n      <th>BASEC<\/th>\n      <th>CHG<\/th>\n      <th>PCHG<\/th>\n      <th>ASEQ<\/th>\n      <th>SUBJID<\/th>\n      <th>RFSTDTC<\/th>\n      <th>RFENDTC<\/th>\n      <th>RFXSTDTC<\/th>\n      <th>RFXENDTC<\/th>\n      <th>RFICDTC<\/th>\n      <th>RFPENDTC<\/th>\n      <th>DTHDTC<\/th>\n      <th>DTHFL<\/th>\n      <th>SITEID<\/th>\n      <th>AGE<\/th>\n      <th>AGEU<\/th>\n      <th>SEX<\/th>\n      <th>RACE<\/th>\n      <th>ETHNIC<\/th>\n      <th>ARMCD<\/th>\n      <th>ARM<\/th>\n      <th>ACTARMCD<\/th>\n      <th>ACTARM<\/th>\n      <th>COUNTRY<\/th>\n      <th>DMDTC<\/th>\n      <th>DMDY<\/th>\n      <th>TRTSDTM<\/th>\n      <th>TRTSTMF<\/th>\n      <th>TRTEDTM<\/th>\n      <th>TRTETMF<\/th>\n      <th>TRTDURD<\/th>\n      <th>SCRFDT<\/th>\n      <th>EOSDT<\/th>\n      <th>EOSSTT<\/th>\n      <th>FRVDT<\/th>\n      <th>RANDDT<\/th>\n      <th>DTHDT<\/th>\n      <th>DTHADY<\/th>\n      <th>LDDTHELD<\/th>\n      <th>LSTALVDT<\/th>\n      <th>AGEGR1<\/th>\n      <th>SAFFL<\/th>\n      <th>RACEGR1<\/th>\n      <th>REGION1<\/th>\n      <th>LDDTHGR1<\/th>\n      <th>DTH30FL<\/th>\n      <th>DTHA30FL<\/th>\n      <th>DTHB30FL<\/th>\n      <th>AVALCA1N<\/th>\n      <th>AVALCAT1<\/th>\n    <\/tr>\n  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 </div>
 <div class="section level3">
 <h3 id="critflags">Deriving Criterion Flags for BCVA Change<a class="anchor" aria-label="anchor" href="#critflags"></a>
@@ -465,8 +459,8 @@ <h3 id="critflags">Deriving Criterion Flags for BCVA Change<a class="anchor" ari
 <span><span class="op">)</span></span></code></pre></div>
 <p>The resulting output is shown below (limited to the first patient
 only):</p>
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type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"display: none;position: absolute;width: 200px;opacity: 1\">\n      <div data-min=\"-75\" data-max=\"62\" data-scale=\"15\"><\/div>\n      <span style=\"float: left;\"><\/span>\n      <span style=\"float: right;\"><\/span>\n    <\/div>\n  <\/td>\n  <td data-type=\"factor\" style=\"vertical-align: top;\">\n    <div class=\"form-group has-feedback\" style=\"margin-bottom: auto;\">\n      <input type=\"search\" placeholder=\"All\" class=\"form-control\" style=\"width: 100%;\"/>\n      <span class=\"glyphicon glyphicon-remove-circle form-control-feedback\"><\/span>\n    <\/div>\n    <div style=\"width: 100%; display: none;\">\n      <select multiple=\"multiple\" style=\"width: 100%;\" data-options=\"[&quot;5 &lt;= CHG &lt;= 10&quot;]\"><\/select>\n    <\/div>\n  <\/td>\n  <td 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<th>CHG<\/th>\n      <th>CRIT1<\/th>\n      <th>CRIT1FL<\/th>\n      <th>CRIT2<\/th>\n      <th>CRIT2FL<\/th>\n      <th>CRIT3<\/th>\n      <th>CRIT3FL<\/th>\n      <th>CRIT4<\/th>\n      <th>CRIT4FL<\/th>\n      <th>CRIT5<\/th>\n      <th>CRIT5FL<\/th>\n    <\/tr>\n  <\/thead>\n<\/table>","options":{"columnDefs":[{"className":"dt-right","targets":[2,3]}],"searchHighlight":true,"searching":true,"pageLength":5,"lengthMenu":[5,10,15,20,50,100],"dom":"<Bfr<\"dt-scroll\"t>ipl>","buttons":[{"extend":"colvis","text":"Choose the columns to display","scroller":true,"collectionLayout":"fixed two-column"}],"colReorder":true,"order":[],"autoWidth":false,"orderClasses":false,"orderCellsTop":true}},"evals":[],"jsHooks":[]}</script><p>It is also possible to assign significance to the “x” in
 <code>CRITxFL</code>. For instance, one could designate all criterion
 flags of Class 1 as <code>CRIT1yFL</code>, Class 2 as
 <code>CRIT2yFL</code>, and Class 3 as <code>CRIT3yFL</code>. The
diff --git a/articles/admiralophtha.html b/articles/admiralophtha.html
index 8fc27c1a..fc810212 100644
--- a/articles/admiralophtha.html
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-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0.9002</small>
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-  </a>
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   <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha" aria-label="github">
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diff --git a/articles/adoe.html b/articles/adoe.html
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   <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha" aria-label="github">
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diff --git a/articles/advfq.html b/articles/advfq.html
index 5f7df355..bf14da18 100644
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-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0.9002</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0</small>
 
     
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-  </a>
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-  <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha/issues/new/choose" aria-label="New Issue">
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   <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha" aria-label="github">
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diff --git a/articles/articles/website-versions.html b/articles/articles/website-versions.html
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+<html>
+  <head>
+    <meta http-equiv="refresh" content="0;URL=https://pharmaverse.github.io/admiralophtha/articles/website-versions.html" />
+    <meta name="robots" content="noindex">
+    <link rel="canonical" href="https://pharmaverse.github.io/admiralophtha/articles/website-versions.html">
+  </head>
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+
diff --git a/articles/index.html b/articles/index.html
index 13e64aa3..78592fb8 100644
--- a/articles/index.html
+++ b/articles/index.html
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-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0.9002</small>
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     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
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-  </a>
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-  <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha/issues/new/choose" aria-label="New Issue">
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@@ -79,6 +67,8 @@ <h3>All vignettes</h3>
         <dd>
         </dd><dt><a href="advfq.html">Creating ADVFQ</a></dt>
         <dd>
+        </dd><dt><a href="website-versions.html">Previous Versions of Website</a></dt>
+        <dd>
         </dd><dt><a href="standards.html">Ophthalmology Standards</a></dt>
         <dd>
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diff --git a/articles/standards.html b/articles/standards.html
index e2c655eb..8421b63c 100644
--- a/articles/standards.html
+++ b/articles/standards.html
@@ -33,7 +33,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">admiralophtha</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0.9002</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -66,18 +66,6 @@
 </form>
 
       <ul class="navbar-nav">
-<li class="nav-item">
-  <a class="external-link nav-link" href="https://app.slack.com/client/T028PB489D3/C02M8KN8269" aria-label="Slack">
-    <span class="fa fa-slack"></span>
-     
-  </a>
-</li>
-<li class="nav-item">
-  <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha/issues/new/choose" aria-label="New Issue">
-    <span class="fa fa-bug"></span>
-     
-  </a>
-</li>
 <li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha" aria-label="github">
     <span class="fab fa fab fa-github fa-lg"></span>
diff --git a/articles/website-versions.html b/articles/website-versions.html
new file mode 100644
index 00000000..4d29dc82
--- /dev/null
+++ b/articles/website-versions.html
@@ -0,0 +1,120 @@
+<!DOCTYPE html>
+<!-- Generated by pkgdown: do not edit by hand --><html lang="en">
+<head>
+<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
+<meta charset="utf-8">
+<meta http-equiv="X-UA-Compatible" content="IE=edge">
+<meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no">
+<meta name="description" content="admiralophtha">
+<title>Previous Versions of Website • admiralophtha</title>
+<!-- favicons --><link rel="icon" type="image/png" sizes="16x16" href="../favicon-16x16.png">
+<link rel="icon" type="image/png" sizes="32x32" href="../favicon-32x32.png">
+<link rel="apple-touch-icon" type="image/png" sizes="180x180" href="../apple-touch-icon.png">
+<link rel="apple-touch-icon" type="image/png" sizes="120x120" href="../apple-touch-icon-120x120.png">
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+<link rel="apple-touch-icon" type="image/png" sizes="60x60" href="../apple-touch-icon-60x60.png">
+<script src="../deps/jquery-3.6.0/jquery-3.6.0.min.js"></script><meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no">
+<link href="../deps/bootstrap-5.2.2/bootstrap.min.css" rel="stylesheet">
+<script src="../deps/bootstrap-5.2.2/bootstrap.bundle.min.js"></script><!-- Font Awesome icons --><link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous">
+<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous">
+<!-- bootstrap-toc --><script src="https://cdn.jsdelivr.net/gh/afeld/bootstrap-toc@v1.0.1/dist/bootstrap-toc.min.js" integrity="sha256-4veVQbu7//Lk5TSmc7YV48MxtMy98e26cf5MrgZYnwo=" crossorigin="anonymous"></script><!-- headroom.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script><!-- clipboard.js --><script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script><!-- search --><script src="https://cdnjs.cloudflare.com/ajax/libs/fuse.js/6.4.6/fuse.js" integrity="sha512-zv6Ywkjyktsohkbp9bb45V6tEMoWhzFzXis+LrMehmJZZSys19Yxf1dopHx7WzIKxr5tK2dVcYmaCk2uqdjF4A==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/autocomplete.js/0.38.0/autocomplete.jquery.min.js" integrity="sha512-GU9ayf+66Xx2TmpxqJpliWbT5PiGYxpaG8rfnBEk1LL8l1KGkRShhngwdXK1UgqhAzWpZHSiYPc09/NwDQIGyg==" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mark.js/8.11.1/mark.min.js" integrity="sha512-5CYOlHXGh6QpOFA/TeTylKLWfB3ftPsde7AnmhuitiTX4K5SqCLBeKro6sPS8ilsz1Q4NRx3v8Ko2IBiszzdww==" crossorigin="anonymous"></script><!-- pkgdown --><script src="../pkgdown.js"></script><meta property="og:title" content="Previous Versions of Website">
+<meta property="og:description" content="admiralophtha">
+<meta property="og:image" content="https://pharmaverse.github.io/admiralophtha/logo.png">
+<!-- mathjax --><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script><script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script><!--[if lt IE 9]>
+<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
+<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
+<![endif]-->
+</head>
+<body>
+    <a href="#main" class="visually-hidden-focusable">Skip to contents</a>
+    
+
+    <nav class="navbar fixed-top navbar-dark navbar-expand-lg bg-primary"><div class="container">
+    
+    <a class="navbar-brand me-2" href="../index.html">admiralophtha</a>
+
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0</small>
+
+    
+    <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
+      <span class="navbar-toggler-icon"></span>
+    </button>
+
+    <div id="navbar" class="collapse navbar-collapse ms-3">
+      <ul class="navbar-nav me-auto">
+<li class="nav-item">
+  <a class="nav-link" href="../articles/admiralophtha.html">Get Started</a>
+</li>
+<li class="nav-item">
+  <a class="nav-link" href="../reference/index.html">Reference</a>
+</li>
+<li class="nav-item dropdown">
+  <a href="#" class="nav-link dropdown-toggle" data-bs-toggle="dropdown" role="button" aria-expanded="false" aria-haspopup="true" id="dropdown-user-guides">User Guides</a>
+  <div class="dropdown-menu" aria-labelledby="dropdown-user-guides">
+    <a class="dropdown-item" href="../articles/standards.html">Ophthalmology Standards</a>
+    <a class="dropdown-item" href="../articles/adoe.html">Creating ADOE</a>
+    <a class="dropdown-item" href="../articles/adbcva.html">Creating ADBCVA</a>
+    <a class="dropdown-item" href="../articles/advfq.html">Creating ADVFQ</a>
+  </div>
+</li>
+<li class="nav-item">
+  <a class="nav-link" href="../news/index.html">Changelog</a>
+</li>
+      </ul>
+<form class="form-inline my-2 my-lg-0" role="search">
+        <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off">
+</form>
+
+      <ul class="navbar-nav">
+<li class="nav-item">
+  <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha" aria-label="github">
+    <span class="fab fa fab fa-github fa-lg"></span>
+     
+  </a>
+</li>
+      </ul>
+</div>
+
+    
+  </div>
+</nav><div class="container template-article">
+
+
+
+
+<div class="row">
+  <main id="main" class="col-md-9"><div class="page-header">
+      <img src="../logo.png" class="logo" alt=""><h1>Previous Versions of Website</h1>
+            
+      
+      <small class="dont-index">Source: <a href="https://github.com/pharmaverse/admiralophtha/blob/main/vignettes/articles/website-versions.Rmd" class="external-link"><code>vignettes/articles/website-versions.Rmd</code></a></small>
+      <div class="d-none name"><code>website-versions.Rmd</code></div>
+    </div>
+
+    
+    
+
+  </main>
+</div>
+
+
+
+    <footer><div class="pkgdown-footer-left">
+  <p></p>
+<p>Developed by Edoardo Mancini, Ritika Aggarwal, Jane Gao, William Holmes, Josie Jackson, Sonali Jain, Yuki Matsunaga, Gordon Miller, Rachel Linacre, Lucy Palmen, Nandini R Thampi, Aldrich Salva.</p>
+</div>
+
+<div class="pkgdown-footer-right">
+  <p></p>
+<p>Site built with <a href="https://pkgdown.r-lib.org/" class="external-link">pkgdown</a> 2.0.7.</p>
+</div>
+
+    </footer>
+</div>
+
+  
+
+  
+
+  </body>
+</html>
diff --git a/authors.html b/authors.html
index ee82f091..6b1dba7f 100644
--- a/authors.html
+++ b/authors.html
@@ -10,7 +10,7 @@
     
     <a class="navbar-brand me-2" href="index.html">admiralophtha</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0.9002</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -40,18 +40,6 @@
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       <ul class="navbar-nav"><li class="nav-item">
-  <a class="external-link nav-link" href="https://app.slack.com/client/T028PB489D3/C02M8KN8269" aria-label="Slack">
-    <span class="fa fa-slack"></span>
-     
-  </a>
-</li>
-<li class="nav-item">
-  <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha/issues/new/choose" aria-label="New Issue">
-    <span class="fa fa-bug"></span>
-     
-  </a>
-</li>
-<li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha" aria-label="github">
     <span class="fab fa fab fa-github fa-lg"></span>
      
diff --git a/index.html b/index.html
index bcb84599..b90c32d9 100644
--- a/index.html
+++ b/index.html
@@ -43,7 +43,7 @@
     
     <a class="navbar-brand me-2" href="index.html">admiralophtha</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0.9002</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -76,18 +76,6 @@
 </form>
 
       <ul class="navbar-nav">
-<li class="nav-item">
-  <a class="external-link nav-link" href="https://app.slack.com/client/T028PB489D3/C02M8KN8269" aria-label="Slack">
-    <span class="fa fa-slack"></span>
-     
-  </a>
-</li>
-<li class="nav-item">
-  <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha/issues/new/choose" aria-label="New Issue">
-    <span class="fa fa-bug"></span>
-     
-  </a>
-</li>
 <li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha" aria-label="github">
     <span class="fab fa fab fa-github fa-lg"></span>
@@ -135,7 +123,7 @@ <h2 id="scope">Scope<a class="anchor" aria-label="anchor" href="#scope"></a>
 <h2 id="references-and-documentation">References and Documentation<a class="anchor" aria-label="anchor" href="#references-and-documentation"></a>
 </h2>
 <ul>
-<li>Please refer to the <a href="https://pharmaverse.github.io/admiral/cran-release/" class="external-link">{admiral} References and Documentation</a>.</li>
+<li>Please refer to the <a href="https://pharmaverse.github.io/admiral/devel/" class="external-link">{admiral} References and Documentation</a>.</li>
 </ul>
 </div>
 <div class="section level2">
@@ -165,7 +153,7 @@ <h2 id="release-schedule">Release Schedule<a class="anchor" aria-label="anchor"
 <li>The first release (v. 0.1.0) came out on 13th March 2023.</li>
 <li>The second release (v. 0.2.0) came out on 12th June 2023.</li>
 <li>The third release (v. 0.3.0) came out on 18th September 2023.</li>
-<li>We are planning for a fourth release (v.1.0) on December 11th 2023. The objective of the 1.0 release of <a href="https://pharmaverse.github.io/admiralophtha/">admiralophtha</a> is to provide a package that is mature enough to be used as it is as part of the ADaM work on any ophthalmology study.</li>
+<li>We are planning for a fourth release before the end of 2023.</li>
 </ul>
 </div>
 </div>
diff --git a/news/index.html b/news/index.html
index fe8eb17f..05c261f8 100644
--- a/news/index.html
+++ b/news/index.html
@@ -10,7 +10,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">admiralophtha</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0.9002</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -40,18 +40,6 @@
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
       <ul class="navbar-nav"><li class="nav-item">
-  <a class="external-link nav-link" href="https://app.slack.com/client/T028PB489D3/C02M8KN8269" aria-label="Slack">
-    <span class="fa fa-slack"></span>
-     
-  </a>
-</li>
-<li class="nav-item">
-  <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha/issues/new/choose" aria-label="New Issue">
-    <span class="fa fa-bug"></span>
-     
-  </a>
-</li>
-<li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha" aria-label="github">
     <span class="fab fa fab fa-github fa-lg"></span>
      
@@ -68,22 +56,6 @@
       <small>Source: <a href="https://github.com/pharmaverse/admiralophtha/blob/main/NEWS.md" class="external-link"><code>NEWS.md</code></a></small>
     </div>
 
-    <div class="section level2">
-<h2 class="pkg-version" data-toc-text="development version" id="admiralophtha-development-version">admiralophtha (development version)<a class="anchor" aria-label="anchor" href="#admiralophtha-development-version"></a></h2>
-<div class="section level3">
-<h3 id="updates-to-templates-development-version">Updates to Templates<a class="anchor" aria-label="anchor" href="#updates-to-templates-development-version"></a></h3>
-<ul><li>Removed <code>analysis_value</code> argument in the calls to <code><a href="https://pharmaverse.github.io/admiral/reference/derive_param_computed.html" class="external-link">derive_param_computed()</a></code> in ADBCVA template in line with the deprecation of this argument in the new version of <a href="https://pharmaverse.github.io/admiral/" class="external-link">admiral</a>. Variable values for parameters of interest are now all populated through the <code>set_values_to</code> argument (<a href="https://github.com/pharmaverse/admiralophtha/issues/207" class="external-link">#207</a>).</li>
-</ul></div>
-<div class="section level3">
-<h3 id="updates-to-documentation-development-version">Updates to Documentation<a class="anchor" aria-label="anchor" href="#updates-to-documentation-development-version"></a></h3>
-<ul><li>Added release date for <a href="https://pharmaverse.github.io/admiralophtha/">admiralophtha</a> 1.0 to the front page (<a href="https://github.com/pharmaverse/admiralophtha/issues/203" class="external-link">#203</a>).</li>
-<li>Removed <code>analysis_value</code> argument in the calls to <code><a href="https://pharmaverse.github.io/admiral/reference/derive_param_computed.html" class="external-link">derive_param_computed()</a></code> in ADBCVA vignette in line with the deprecation of this argument in the new version of <a href="https://pharmaverse.github.io/admiral/" class="external-link">admiral</a>. Variable values for parameters of interest are now all populated through the <code>set_values_to</code> argument (<a href="https://github.com/pharmaverse/admiralophtha/issues/207" class="external-link">#207</a>).</li>
-</ul></div>
-<div class="section level3">
-<h3 id="various-development-version">Various<a class="anchor" aria-label="anchor" href="#various-development-version"></a></h3>
-<ul><li>Website now has button/links to Slack channel and GitHub Issues (<a href="https://github.com/pharmaverse/admiralophtha/issues/206" class="external-link">#206</a>).</li>
-</ul></div>
-</div>
     <div class="section level2">
 <h2 class="pkg-version" data-toc-text="0.3.0" id="admiralophtha-030">admiralophtha 0.3.0<a class="anchor" aria-label="anchor" href="#admiralophtha-030"></a></h2>
 <div class="section level3">
diff --git a/pkgdown.yml b/pkgdown.yml
index 038a54f4..a8c96a25 100644
--- a/pkgdown.yml
+++ b/pkgdown.yml
@@ -6,8 +6,9 @@ articles:
   admiralophtha: admiralophtha.html
   adoe: adoe.html
   advfq: advfq.html
+  website-versions: website-versions.html
   standards: standards.html
-last_built: 2023-11-09T16:08Z
+last_built: 2023-11-09T16:18Z
 urls:
   reference: https://pharmaverse.github.io/admiralophtha/reference
   article: https://pharmaverse.github.io/admiralophtha/articles
diff --git a/pull_request_template.html b/pull_request_template.html
index cc0e5247..70c8eddb 100644
--- a/pull_request_template.html
+++ b/pull_request_template.html
@@ -10,7 +10,7 @@
     
     <a class="navbar-brand me-2" href="index.html">admiralophtha</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0.9002</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -40,18 +40,6 @@
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
       <ul class="navbar-nav"><li class="nav-item">
-  <a class="external-link nav-link" href="https://app.slack.com/client/T028PB489D3/C02M8KN8269" aria-label="Slack">
-    <span class="fa fa-slack"></span>
-     
-  </a>
-</li>
-<li class="nav-item">
-  <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha/issues/new/choose" aria-label="New Issue">
-    <span class="fa fa-bug"></span>
-     
-  </a>
-</li>
-<li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha" aria-label="github">
     <span class="fab fa fab fa-github fa-lg"></span>
      
diff --git a/reference/admiralophtha-package.html b/reference/admiralophtha-package.html
index 847d5c04..0a308900 100644
--- a/reference/admiralophtha-package.html
+++ b/reference/admiralophtha-package.html
@@ -12,7 +12,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">admiralophtha</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0.9002</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -42,18 +42,6 @@
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
       <ul class="navbar-nav"><li class="nav-item">
-  <a class="external-link nav-link" href="https://app.slack.com/client/T028PB489D3/C02M8KN8269" aria-label="Slack">
-    <span class="fa fa-slack"></span>
-     
-  </a>
-</li>
-<li class="nav-item">
-  <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha/issues/new/choose" aria-label="New Issue">
-    <span class="fa fa-bug"></span>
-     
-  </a>
-</li>
-<li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha" aria-label="github">
     <span class="fab fa fab fa-github fa-lg"></span>
      
diff --git a/reference/admiralophtha_adbcva.html b/reference/admiralophtha_adbcva.html
index d20b2045..eeb6e3b2 100644
--- a/reference/admiralophtha_adbcva.html
+++ b/reference/admiralophtha_adbcva.html
@@ -10,7 +10,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">admiralophtha</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0.9002</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -40,18 +40,6 @@
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       <ul class="navbar-nav"><li class="nav-item">
-  <a class="external-link nav-link" href="https://app.slack.com/client/T028PB489D3/C02M8KN8269" aria-label="Slack">
-    <span class="fa fa-slack"></span>
-     
-  </a>
-</li>
-<li class="nav-item">
-  <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha/issues/new/choose" aria-label="New Issue">
-    <span class="fa fa-bug"></span>
-     
-  </a>
-</li>
-<li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha" aria-label="github">
     <span class="fab fa fab fa-github fa-lg"></span>
      
diff --git a/reference/admiralophtha_adoe.html b/reference/admiralophtha_adoe.html
index 48c679e9..48334ff1 100644
--- a/reference/admiralophtha_adoe.html
+++ b/reference/admiralophtha_adoe.html
@@ -10,7 +10,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">admiralophtha</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0.9002</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -40,18 +40,6 @@
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       <ul class="navbar-nav"><li class="nav-item">
-  <a class="external-link nav-link" href="https://app.slack.com/client/T028PB489D3/C02M8KN8269" aria-label="Slack">
-    <span class="fa fa-slack"></span>
-     
-  </a>
-</li>
-<li class="nav-item">
-  <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha/issues/new/choose" aria-label="New Issue">
-    <span class="fa fa-bug"></span>
-     
-  </a>
-</li>
-<li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha" aria-label="github">
     <span class="fab fa fab fa-github fa-lg"></span>
      
diff --git a/reference/admiralophtha_advfq.html b/reference/admiralophtha_advfq.html
index c5ae2e05..f282caf1 100644
--- a/reference/admiralophtha_advfq.html
+++ b/reference/admiralophtha_advfq.html
@@ -10,7 +10,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">admiralophtha</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0.9002</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -40,18 +40,6 @@
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       <ul class="navbar-nav"><li class="nav-item">
-  <a class="external-link nav-link" href="https://app.slack.com/client/T028PB489D3/C02M8KN8269" aria-label="Slack">
-    <span class="fa fa-slack"></span>
-     
-  </a>
-</li>
-<li class="nav-item">
-  <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha/issues/new/choose" aria-label="New Issue">
-    <span class="fa fa-bug"></span>
-     
-  </a>
-</li>
-<li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha" aria-label="github">
     <span class="fab fa fab fa-github fa-lg"></span>
      
diff --git a/reference/convert_etdrs_to_logmar.html b/reference/convert_etdrs_to_logmar.html
index f05d550f..4c576339 100644
--- a/reference/convert_etdrs_to_logmar.html
+++ b/reference/convert_etdrs_to_logmar.html
@@ -10,7 +10,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">admiralophtha</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0.9002</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -40,18 +40,6 @@
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       <ul class="navbar-nav"><li class="nav-item">
-  <a class="external-link nav-link" href="https://app.slack.com/client/T028PB489D3/C02M8KN8269" aria-label="Slack">
-    <span class="fa fa-slack"></span>
-     
-  </a>
-</li>
-<li class="nav-item">
-  <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha/issues/new/choose" aria-label="New Issue">
-    <span class="fa fa-bug"></span>
-     
-  </a>
-</li>
-<li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha" aria-label="github">
     <span class="fab fa fab fa-github fa-lg"></span>
      
diff --git a/reference/convert_logmar_to_etdrs.html b/reference/convert_logmar_to_etdrs.html
index 1485d603..3984822c 100644
--- a/reference/convert_logmar_to_etdrs.html
+++ b/reference/convert_logmar_to_etdrs.html
@@ -10,7 +10,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">admiralophtha</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0.9002</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -40,18 +40,6 @@
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       <ul class="navbar-nav"><li class="nav-item">
-  <a class="external-link nav-link" href="https://app.slack.com/client/T028PB489D3/C02M8KN8269" aria-label="Slack">
-    <span class="fa fa-slack"></span>
-     
-  </a>
-</li>
-<li class="nav-item">
-  <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha/issues/new/choose" aria-label="New Issue">
-    <span class="fa fa-bug"></span>
-     
-  </a>
-</li>
-<li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha" aria-label="github">
     <span class="fab fa fab fa-github fa-lg"></span>
      
diff --git a/reference/derive_var_afeye.html b/reference/derive_var_afeye.html
index c90da8f9..e38d780a 100644
--- a/reference/derive_var_afeye.html
+++ b/reference/derive_var_afeye.html
@@ -10,7 +10,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">admiralophtha</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0.9002</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -40,18 +40,6 @@
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       <ul class="navbar-nav"><li class="nav-item">
-  <a class="external-link nav-link" href="https://app.slack.com/client/T028PB489D3/C02M8KN8269" aria-label="Slack">
-    <span class="fa fa-slack"></span>
-     
-  </a>
-</li>
-<li class="nav-item">
-  <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha/issues/new/choose" aria-label="New Issue">
-    <span class="fa fa-bug"></span>
-     
-  </a>
-</li>
-<li class="nav-item">
   <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha" aria-label="github">
     <span class="fab fa fab fa-github fa-lg"></span>
      
diff --git a/reference/derive_var_bcvacritxfl.html b/reference/derive_var_bcvacritxfl.html
index 7590d02a..40f9f012 100644
--- a/reference/derive_var_bcvacritxfl.html
+++ b/reference/derive_var_bcvacritxfl.html
@@ -12,7 +12,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">admiralophtha</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0.9002</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0</small>
 
     
     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
@@ -42,18 +42,6 @@
         <input type="search" class="form-control me-sm-2" aria-label="Toggle navigation" name="search-input" data-search-index="../search.json" id="search-input" placeholder="Search for" autocomplete="off"></form>
 
       <ul class="navbar-nav"><li class="nav-item">
-  <a class="external-link nav-link" href="https://app.slack.com/client/T028PB489D3/C02M8KN8269" aria-label="Slack">
-    <span class="fa fa-slack"></span>
-     
-  </a>
-</li>
-<li class="nav-item">
-  <a class="external-link nav-link" href="https://github.com/pharmaverse/admiralophtha/issues/new/choose" aria-label="New Issue">
-    <span class="fa fa-bug"></span>
-     
-  </a>
-</li>
-<li class="nav-item">
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diff --git a/reference/derive_var_bcvacritxfl_util.html b/reference/derive_var_bcvacritxfl_util.html
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-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0.9002</small>
+    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0</small>
 
     
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diff --git a/reference/derive_var_studyeye.html b/reference/derive_var_studyeye.html
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diff --git a/reference/index.html b/reference/index.html
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@@ -10,7 +10,7 @@
     
     <a class="navbar-brand me-2" href="../index.html">admiralophtha</a>
 
-    <small class="nav-text text-muted me-auto" data-bs-toggle="tooltip" data-bs-placement="bottom" title="">0.3.0.9002</small>
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     <button class="navbar-toggler" type="button" data-bs-toggle="collapse" data-bs-target="#navbar" aria-controls="navbar" aria-expanded="false" aria-label="Toggle navigation">
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diff --git a/search.json b/search.json
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Definitions","title":"Apache License","text":"“License” shall mean terms conditions use, reproduction, distribution defined Sections 1 9 document. “Licensor” shall mean copyright owner entity authorized copyright owner granting License. “Legal Entity” shall mean union acting entity entities control, controlled , common control entity. purposes definition, “control” means () power, direct indirect, cause direction management entity, whether contract otherwise, (ii) ownership fifty percent (50%) outstanding shares, (iii) beneficial ownership entity. “” (“”) shall mean individual Legal Entity exercising permissions granted License. “Source” form shall mean preferred form making modifications, including limited software source code, documentation source, configuration files. “Object” form shall mean form resulting mechanical transformation translation Source form, including limited compiled object code, generated documentation, conversions media types. “Work” shall mean work authorship, whether Source Object form, made available License, indicated copyright notice included attached work (example provided Appendix ). “Derivative Works” shall mean work, whether Source Object form, based (derived ) Work editorial revisions, annotations, elaborations, modifications represent, whole, original work authorship. purposes License, Derivative Works shall include works remain separable , merely link (bind name) interfaces , Work Derivative Works thereof. “Contribution” shall mean work authorship, including original version Work modifications additions Work Derivative Works thereof, intentionally submitted Licensor inclusion Work copyright owner individual Legal Entity authorized submit behalf copyright owner. purposes definition, “submitted” means form electronic, verbal, written communication sent Licensor representatives, including limited communication electronic mailing lists, source code control systems, issue tracking systems managed , behalf , Licensor purpose discussing improving Work, excluding communication conspicuously marked otherwise designated writing copyright owner “Contribution.” “Contributor” shall mean Licensor individual Legal Entity behalf Contribution received Licensor subsequently incorporated within Work.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/LICENSE.html","id":"id_2-grant-of-copyright-license","dir":"","previous_headings":"Terms and Conditions for use, reproduction, and distribution","what":"2. 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(Don’t include brackets!) text enclosed appropriate comment syntax file format. also recommend file class name description purpose included “printed page” copyright notice easier identification within third-party archives.","code":"Copyright 2021 F. Hoffmann-La Roche AG and GlaxoSmithKline LLC  Licensed under the Apache License, Version 2.0 (the \"License\"); you may not use this file except in compliance with the License. You may obtain a copy of the License at    http://www.apache.org/licenses/LICENSE-2.0  Unless required by applicable law or agreed to in writing, software distributed under the License is distributed on an \"AS IS\" BASIS, WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. See the License for the specific language governing permissions and limitations under the License."},{"path":"https://pharmaverse.github.io/admiralophtha/articles/adbcva.html","id":"introduction","dir":"Articles","previous_headings":"","what":"Introduction","title":"Creating ADBCVA","text":"article describes creating ADBCVA ADaM Best-Corrected Visual Acuity (BCVA) data ophthalmology endpoints. used conjunction article creating BDS dataset SDTM. , derivations processes specific ADBCVA absent, user invited consult aforementioned article guidance. Note: examples assume CDISC SDTM /ADaM format input unless otherwise specified.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/articles/adbcva.html","id":"dataset-contents","dir":"Articles","previous_headings":"Introduction","what":"Dataset Contents","title":"Creating ADBCVA","text":"name ADBCVA implies, admiralophtha suggests populate ADBCVA solely BCVA records OE SDTM.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/articles/adbcva.html","id":"required-packages","dir":"Articles","previous_headings":"Introduction","what":"Required Packages","title":"Creating ADBCVA","text":"examples vignette require following packages.","code":"library(dplyr) library(admiral) library(pharmaversesdtm) library(admiraldev) library(admiralophtha)"},{"path":"https://pharmaverse.github.io/admiralophtha/articles/adbcva.html","id":"programming-workflow","dir":"Articles","previous_headings":"","what":"Programming Workflow","title":"Creating ADBCVA","text":"Initial Set ADBCVA Deriving LogMAR Score Parameters Derivations Standard BDS Variables Deriving Analysis Value Categories Snellen Scores Deriving Criterion Flags BCVA Change Additional Notes Example Script","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/articles/adbcva.html","id":"setup","dir":"Articles","previous_headings":"Programming Workflow","what":"Initial set up of ADBCVA","title":"Creating ADBCVA","text":"BDS ADaM datasets, one start OE SDTM, BCVA records interest. purposes next two sections, shall using admiral OE ADSL test data. also require lookup table mapping parameter codes. Note: simulate ophthalmology study, add randomly generated STUDYEYE variable ADSL, practice STUDYEYE already derived using derive_var_studyeye(). Following setup, programmer can start constructing ADBCVA. first step subset OE BCVA parameters merge ADSL. required two reasons: firstly, STUDYEYE crucial mapping AFEYE PARAMCD’s. Secondly, treatment start date (TRTSDT) also prerequisite derivation variables Analysis Day (ADY). next item business derive AVAL, AVALU, DTYPE. example, due small number parameters derivation trivial. AFEYE also created step using function derive_var_afeye(). Moving forwards, PARAM PARAMCD can assigned using derive_vars_merged() admiral lookup table param_lookup generated .","code":"data(\"oe_ophtha\") data(\"admiral_adsl\")  # Add STUDYEYE to ADSL to simulate an ophtha dataset adsl <- admiral_adsl %>%   as.data.frame() %>%   mutate(STUDYEYE = sample(c(\"LEFT\", \"RIGHT\"), n(), replace = TRUE)) %>%   convert_blanks_to_na()  oe <- convert_blanks_to_na(oe_ophtha) %>%   ungroup()  # ---- Lookup table ---- param_lookup <- tibble::tribble(   ~OETESTCD, ~OECAT, ~OESCAT, ~AFEYE, ~PARAMCD, ~PARAM, ~PARAMN,   \"VACSCORE\", \"BEST CORRECTED VISUAL ACUITY\", \"OVERALL EVALUATION\", \"Study Eye\", \"SBCVA\", \"Study Eye Visual Acuity Score (letters)\", 1, # nolint   \"VACSCORE\", \"BEST CORRECTED VISUAL ACUITY\", \"OVERALL EVALUATION\", \"Fellow Eye\", \"FBCVA\", \"Fellow Eye Visual Acuity Score (letters)\", 2, # nolint ) adsl_vars <- exprs(TRTSDT, TRTEDT, TRT01A, TRT01P, STUDYEYE)  adbcva <- oe %>%   filter(     OETESTCD %in% c(\"VACSCORE\")   ) %>%   derive_vars_merged(     dataset_add = adsl,     new_vars = adsl_vars,     by_vars = exprs(STUDYID, USUBJID)   ) adbcva <- adbcva %>%   mutate(     AVAL = OESTRESN,     AVALU = \"letters\",     DTYPE = NA_character_   ) %>%   derive_var_afeye(OELOC, OELAT) adbcva <- adbcva %>%   derive_vars_merged(     dataset_add = param_lookup,     new_vars = exprs(PARAM, PARAMCD),     by_vars = exprs(OETESTCD, AFEYE),     filter_add = PARAMCD %in% c(\"SBCVA\", \"FBCVA\")   )"},{"path":"https://pharmaverse.github.io/admiralophtha/articles/adbcva.html","id":"logmar","dir":"Articles","previous_headings":"Programming Workflow","what":"Deriving LogMAR Score Parameters","title":"Creating ADBCVA","text":"Often ADBCVA datasets contain derived records BCVA LogMAR units. can easily achieved follows using derive_param_computed(). conversion units done using convert_etdrs_to_logmar(). Two separate calls required due parameters split study fellow eye. extra parameters added, records end dataset now present, AVALC day/date variables ADY ADT can derived. Importantly, calls derive_param_computed() list SDTM variables VISIT, VISITNUM, OEDY OEDTC by_vars function. necessary derive ADaM variables AVISIT ADY successive steps. ADaM variables require derived, SDTM variables set missing derived records, per ADaM standards:","code":"adbcva <- adbcva %>%   derive_param_computed(     by_vars = c(exprs(STUDYID, USUBJID, VISIT, VISITNUM, OEDY, OEDTC, AFEYE), adsl_vars),     parameters = c(\"SBCVA\"),     set_values_to = exprs(       AVAL = convert_etdrs_to_logmar(AVAL.SBCVA),       PARAMCD = \"SBCVALOG\",       PARAM = \"Study Eye Visual Acuity LogMAR Score\",       DTYPE = NA_character_,       AVALU = \"LogMAR\"     )   ) %>%   derive_param_computed(     by_vars = c(exprs(STUDYID, USUBJID, VISIT, OEDY, OEDTC, AFEYE), adsl_vars),     parameters = c(\"FBCVA\"),     set_values_to = exprs(       AVAL = convert_etdrs_to_logmar(AVAL.FBCVA),       PARAMCD = \"FBCVALOG\",       PARAM = \"Fellow Eye Visual Acuity LogMAR Score\",       DTYPE = NA_character_,       AVALU = \"LogMAR\"     )   ) %>%   mutate(AVALC = as.character(AVAL)) %>%   derive_vars_dt(     new_vars_prefix = \"A\",     dtc = OEDTC,     flag_imputation = \"none\"   ) %>%   derive_vars_dy(reference_date = TRTSDT, source_vars = exprs(ADT)) adbcva <- adbcva %>%   mutate(     VISIT = ifelse(PARAMCD %in% c(\"SBCVALOG\", \"FBCVALOG\"), NA_character_, VISIT),     VISITNUM = ifelse(PARAMCD %in% c(\"SBCVALOG\", \"FBCVALOG\"), NA, VISITNUM),     OEDY = ifelse(PARAMCD %in% c(\"SBCVALOG\", \"FBCVALOG\"), NA, OEDY),     OEDTC = ifelse(PARAMCD %in% c(\"SBCVALOG\", \"FBCVALOG\"), NA_character_, OEDTC)   )"},{"path":"https://pharmaverse.github.io/admiralophtha/articles/adbcva.html","id":"further","dir":"Articles","previous_headings":"Programming Workflow","what":"Further Derivations of Standard BDS Variables","title":"Creating ADBCVA","text":"user invited consult article creating BDS dataset SDTM learn add standard BDS variables ADBCVA. Henceforth, purposes article, following sections use ADBCVA dataset generated corresponding admiralophtha template program starting point. Note: dataset already comes criterion flags analysis value categorisation variables, illustration purposes removed.","code":"data(\"admiralophtha_adbcva\")  adbcva <- admiralophtha_adbcva %>%   select(-starts_with(\"CRIT\"), -starts_with(\"AVALCA\"))"},{"path":"https://pharmaverse.github.io/admiralophtha/articles/adbcva.html","id":"avalcats","dir":"Articles","previous_headings":"Programming Workflow","what":"Deriving Analysis Value Categories for Snellen Scores","title":"Creating ADBCVA","text":"ophthalmology studies may desire subdivide BCVA records according Snellen category fall (eg, 20/320, 20/100, 20/20 etc). best done use AVALCATx/AVALCAxN variable pairs. Currently, admiralophtha provide specific functionality create AVALCATx/AVALCAxN pairs, although may included future releases package. current toolset, suggested approach derive variables : Create lookup table assigns numeric equivalents (.e. AVALCAxN) Snellen categories. Create format function map AVAL numeric category. Add AVALCAxN mutate statement using format function. Add AVALCATx using derive_vars_merged combination lookup table. resulting output shown (limited first patient ):","code":"avalcat_lookup <- tibble::tribble(   ~PARAMCD, ~AVALCA1N, ~AVALCAT1,   \"SBCVA\", 1000, \"< 20/800\",   \"SBCVA\", 800, \"20/800\",   \"SBCVA\", 640, \"20/640\",   \"SBCVA\", 500, \"20/500\",   \"SBCVA\", 400, \"20/400\",   \"SBCVA\", 320, \"20/320\",   \"SBCVA\", 250, \"20/250\",   \"SBCVA\", 200, \"20/200\",   \"SBCVA\", 160, \"20/160\",   \"SBCVA\", 125, \"20/125\",   \"SBCVA\", 100, \"20/100\",   \"SBCVA\", 80, \"20/80\",   \"SBCVA\", 63, \"20/63\",   \"SBCVA\", 50, \"20/50\",   \"SBCVA\", 40, \"20/40\",   \"SBCVA\", 32, \"20/32\",   \"SBCVA\", 25, \"20/25\",   \"SBCVA\", 20, \"20/20\",   \"SBCVA\", 16, \"20/16\",   \"SBCVA\", 12, \"20/12\",   \"SBCVA\", 1, \"> 20/12\", )  avalcat_lookup <- avalcat_lookup %>%   mutate(PARAMCD = \"FBCVA\") %>%   rbind(avalcat_lookup)  format_avalcat1n <- function(param, aval) {   case_when(     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 0 & aval <= 3 ~ 1000,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 4 & aval <= 8 ~ 800,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 9 & aval <= 13 ~ 640,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 14 & aval <= 18 ~ 500,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 19 & aval <= 23 ~ 400,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 24 & aval <= 28 ~ 320,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 29 & aval <= 33 ~ 250,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 34 & aval <= 38 ~ 200,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 39 & aval <= 43 ~ 160,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 44 & aval <= 48 ~ 125,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 49 & aval <= 53 ~ 100,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 54 & aval <= 58 ~ 80,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 59 & aval <= 63 ~ 63,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 64 & aval <= 68 ~ 50,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 69 & aval <= 73 ~ 40,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 74 & aval <= 78 ~ 32,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 79 & aval <= 83 ~ 25,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 84 & aval <= 88 ~ 20,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 89 & aval <= 93 ~ 16,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 94 & aval <= 97 ~ 12,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 98 ~ 1   ) }  adbcva <- adbcva %>%   mutate(AVALCA1N = format_avalcat1n(param = PARAMCD, aval = AVAL)) %>%   derive_vars_merged(     avalcat_lookup,     by = exprs(PARAMCD, AVALCA1N)   )"},{"path":"https://pharmaverse.github.io/admiralophtha/articles/adbcva.html","id":"critflags","dir":"Articles","previous_headings":"Programming Workflow","what":"Deriving Criterion Flags for BCVA Change","title":"Creating ADBCVA","text":"admiralophtha suggests use criterion flag variable pairs (CRITx/CRITxFL) program BCVA endpoints Avoiding loss x letters Gain y letters Gain x y letters (relative baseline basetypes). package provides function derive_var_bcvacritxfl() program endpoints efficiently consistently. terms logic apply variable CHG, endpoints fall three classes, can represented inequalities: Class 1: CHG value lying inside range, <= CHG <= b. Class 2: CHG value upper limit, CHG <= . Class 3: CHG value lower limit, CHG => b. using derive_var_bcvacritxfl(), ADaM programmer can implement three types endpoint . achieved feeding appropriate ranges, upper limits lower limits bcva_ranges, bcva_uplims bcva_lowlims arguments function. instance, let’s suppose endpoints interest : Gain 5 10 letters relative baseline (Class 1: 5 <= CHG <= 10) Gain 25 letters fewer relative baseline (Class 2: CHG <= 25) Loss 5 letters relative baseline (Class 2: CHG <= -5) Gain 15 letters relative baseline (Class 3: CHG >= 15) Loss 10 letters fewer relative baseline (Class 3: CHG >= -10). , following call implement criterion variable/flag pairs endpoints . CRITx variables automatically encode correct inequality. Note restrict_derivation() wrapped around call derive variables relevant parameters. way, filter argument can altered restrict derivation relevant records. Note also argument crit_var = exprs(CHG) specified criterion flags derived respect correct variable. resulting output shown (limited first patient ): also possible assign significance “x” CRITxFL. instance, one designate criterion flags Class 1 CRIT1yFL, Class 2 CRIT2yFL, Class 3 CRIT3yFL. argument critxfl_index allows simple implementation conjunction three separate calls derive_var_bcvacritxfl():","code":"adbcva <- adbcva %>% restrict_derivation(   derivation = derive_var_bcvacritxfl,   args = params(     crit_var = exprs(CHG),     bcva_ranges = list(c(5, 10)),     bcva_uplims = list(25, -5),     bcva_lowlims = list(15, -10)   ),   filter = PARAMCD %in% c(\"SBCVA\", \"FBCVA\") ) adbcva <- adbcva %>%   restrict_derivation(     derivation = derive_var_bcvacritxfl,     args = params(       crit_var = exprs(CHG),       bcva_ranges = list(c(5, 10)),       critxfl_index = 10     ),     filter = PARAMCD %in% c(\"SBCVA\", \"FBCVA\")   ) %>%   restrict_derivation(     derivation = derive_var_bcvacritxfl,     args = params(       crit_var = exprs(CHG),       bcva_uplims = list(25, -5),       critxfl_index = 20     ),     filter = PARAMCD %in% c(\"SBCVA\", \"FBCVA\")   ) %>%   restrict_derivation(     derivation = derive_var_bcvacritxfl,     args = params(       crit_var = exprs(CHG),       bcva_lowlims = list(15, -10),       critxfl_index = 30     ),     filter = PARAMCD %in% c(\"SBCVA\", \"FBCVA\")   )"},{"path":"https://pharmaverse.github.io/admiralophtha/articles/adbcva.html","id":"additional-notes","dir":"Articles","previous_headings":"Programming Workflow","what":"Additional Notes","title":"Creating ADBCVA","text":"interpreting endpoints Loss 5 letters fewer relative baseline, implicitly assumed article also includes case letters gained, inequality reads CHG >= -5. One use bcva_lowlims = list(-5) argument derive_var_bcvacritxfl() program endpoint. case, .e. one wishes exclude cases letter gains, inequality interest instead -5 <= CHG <= -1. Importantly, derive_var_bcvacritxfl() still used, argument bcva_ranges = list(c(-5, -1)). vignette extensively showcases use derive_var_bcvacritxfl() applied variable CHG, argument crit_var function can also used create criterion flag relative variables (e.g. crit_var = exprs(AVAL) AVAL).","code":""},{"path":[]},{"path":"https://pharmaverse.github.io/admiralophtha/articles/admiralophtha.html","id":"introduction","dir":"Articles","previous_headings":"","what":"Introduction","title":"Get Started","text":"package extension, new admiral best place first start reading Get Started guide. extension package follows main idea conventions, re-uses many functions admiral, important thoroughly understand able use admiralophtha.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/articles/admiralophtha.html","id":"derivations","dir":"Articles","previous_headings":"","what":"Derivations","title":"Get Started","text":"important functions admiralophtha derivations. follow conventions admiral focused ophthalmology-specific needs.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/articles/admiralophtha.html","id":"starting-a-script","dir":"Articles","previous_headings":"","what":"Starting a Script","title":"Get Started","text":"ophthalmology ADaM data structures, overview flow example function calls common steps provided following vignettes: Creating ADBCVA Creating ADOE Creating ADVFQ","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/articles/admiralophtha.html","id":"support","dir":"Articles","previous_headings":"","what":"Support","title":"Get Started","text":"Support provided via admiral Slack channel.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/articles/adoe.html","id":"introduction","dir":"Articles","previous_headings":"","what":"Introduction","title":"Creating ADOE","text":"article describes creating ADOE ADaM Ophthalmology Exam Analysis data ophthalmology endpoints. used conjunction article creating BDS dataset SDTM. , derivations processes specific ADOE absent, user invited consult aforementioned article guidance. current release admiralophtha contain functionality specific ADOE, article showcases map parameters OE order set basic structure ADOE. following steps, user invited consult -linked article BDS datasets. article updated future releases showcase explain admiralophtha-specific functionality. Note: examples assume CDISC SDTM /ADaM format input unless otherwise specified.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/articles/adoe.html","id":"dataset-contents","dir":"Articles","previous_headings":"Introduction","what":"Dataset Contents","title":"Creating ADOE","text":"admiralophtha suggests populate ADOE general miscellaneous ophthalmology parameters. efficacy endpoint-related parameters (eg. BCVA tests) placed separate datasets (eg. ADBCVA).","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/articles/adoe.html","id":"required-packages","dir":"Articles","previous_headings":"Introduction","what":"Required Packages","title":"Creating ADOE","text":"examples vignette require following packages.","code":"library(dplyr) library(admiral) library(pharmaversesdtm) library(admiraldev) library(admiralophtha)"},{"path":"https://pharmaverse.github.io/admiralophtha/articles/adoe.html","id":"programming-workflow","dir":"Articles","previous_headings":"","what":"Programming Workflow","title":"Creating ADOE","text":"Initial Set ADOE Derivations Standard BDS Variables Example Script","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/articles/adoe.html","id":"setup","dir":"Articles","previous_headings":"Programming Workflow","what":"Initial set up of ADOE","title":"Creating ADOE","text":"BDS ADaM datasets, one start OE SDTM, general ophthalmology records interest. purposes next two sections, shall using admiral OE ADSL test data. also require lookup table mapping parameter codes. Note: simulate ophthalmology study, add randomly generated STUDYEYE variable ADSL, practice STUDYEYE already derived using derive_var_studyeye(). Following setup, programmer can start constructing ADOE. first step subset OE general ophthalmology parameters. , one can merge resulting dataset ADSL. required two reasons: firstly, STUDYEYE crucial mapping AFEYE PARAMCD’s. Secondly, treatment start date (TRTSDT) also prerequisite derivation variables Analysis Day (ADY). next item business derive AVAL, AVALU, DTYPE. example, due small number parameters derivation trivial. AFEYE also created step using function derive_var_afeye(). determine affected eye, function compares OELAT STUDYEYE variable created previous step.","code":"data(\"oe_ophtha\") data(\"admiral_adsl\")  # Add STUDYEYE to ADSL to simulate an ophtha dataset adsl <- admiral_adsl %>%   as.data.frame() %>%   mutate(STUDYEYE = sample(c(\"LEFT\", \"RIGHT\"), n(), replace = TRUE)) %>%   convert_blanks_to_na()  oe <- convert_blanks_to_na(oe_ophtha) %>%   ungroup()  # ---- Lookup table ----  # Assign PARAMCD, PARAM, and PARAMN param_lookup <- tibble::tribble(   ~OETESTCD, ~OECAT, ~OESCAT, ~AFEYE, ~PARAMCD, ~PARAM, ~PARAMN,   \"CSUBTH\", \"OPHTHALMIC ASSESSMENTS\", \"SD-OCT CST SINGLE FORM\", \"Study Eye\", \"SCSUBTH\", \"Study Eye Center Subfield Thickness (um)\", 1, # nolint   \"CSUBTH\", \"OPHTHALMIC ASSESSMENTS\", \"SD-OCT CST SINGLE FORM\", \"Fellow Eye\", \"FCSUBTH\", \"Fellow Eye Center Subfield Thickness (um)\", 2, # nolint   \"DRSSR\", \"OPHTHALMIC ASSESSMENTS\", \"SD-OCT CST SINGLE FORM\", \"Study Eye\", \"SDRSSR\", \"Study Eye Diabetic Retinopathy Severity\", 3, # nolint   \"DRSSR\", \"OPHTHALMIC ASSESSMENTS\", \"SD-OCT CST SINGLE FORM\", \"Fellow Eye\", \"FDRSSR\", \"Fellow Eye Diabetic Retinopathy Severity\", 4, # nolint ) adsl_vars <- exprs(TRTSDT, TRTEDT, TRT01A, TRT01P, STUDYEYE)  adoe <- oe %>%   filter(     OETESTCD %in% c(\"CSUBTH\", \"DRSSR\")   ) %>%   derive_vars_merged(     dataset_add = adsl,     new_vars = adsl_vars,     by_vars = exprs(STUDYID, USUBJID)   ) adoe <- adoe %>%   # Calculate AVAL, AVALC, AVALU and DTYPE   mutate(     AVAL = OESTRESN,     AVALC = OESTRESC,     AVALU = OESTRESU,     DTYPE = NA_character_   ) %>%   # Derive AFEYE needed for PARAMCD derivation   derive_var_afeye(OELOC, OELAT, loc_vals = c(\"EYE\", \"RETINA\"))"},{"path":"https://pharmaverse.github.io/admiralophtha/articles/adoe.html","id":"further","dir":"Articles","previous_headings":"Programming Workflow","what":"Further Derivations of Standard BDS Variables","title":"Creating ADOE","text":"user invited consult article creating BDS dataset SDTM learn add standard BDS variables ADOE.","code":""},{"path":[]},{"path":"https://pharmaverse.github.io/admiralophtha/articles/advfq.html","id":"introduction","dir":"Articles","previous_headings":"","what":"Introduction","title":"Creating ADVFQ","text":"article describes creating ADVFQ ADaM Visual Functioning Questionnaire data ophthalmology endpoints. used conjunction article creating BDS dataset SDTM. , derivations processes specific ADVFQ absent, user invited consult aforementioned article guidance. Note: examples assume CDISC SDTM /ADaM format input unless otherwise specified.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/articles/advfq.html","id":"dataset-contents","dir":"Articles","previous_headings":"Introduction","what":"Dataset Contents","title":"Creating ADVFQ","text":"admiralophtha suggests populate ADVFQ solely VFQ records QS SDTM. questionnaire data placed separate datasets (e.g. ADQS).","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/articles/advfq.html","id":"required-packages","dir":"Articles","previous_headings":"Introduction","what":"Required Packages","title":"Creating ADVFQ","text":"examples vignette require following packages.","code":"library(dplyr) library(admiral) library(pharmaversesdtm) library(admiraldev) library(admiralophtha)"},{"path":"https://pharmaverse.github.io/admiralophtha/articles/advfq.html","id":"programming-workflow","dir":"Articles","previous_headings":"","what":"Programming Workflow","title":"Creating ADVFQ","text":"Initial set ADVFQ Derive Analysis Value existing questions (AVAL) Derive Parameters recoded items summary scores Derive Analysis Variables (ANL01FL ASEQ) Add ADSL Variables Example Script","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/articles/advfq.html","id":"setup","dir":"Articles","previous_headings":"Programming Workflow","what":"Initial set up of ADVFQ","title":"Creating ADVFQ","text":"start, datasets needed creation questionnaire dataset read environment. purpose demonstration shall use admiral QS ADSL test data. QS dataset filtered VFQ parameters interest. Next, programmer create parameter lookup table includes QSTESTCD, PARAMCD, PARAM, PARCAT1 PARCAT2 variables. include parameters needed final ADVFQ used later merge parameter information. Now ADVFQ dataset can constructed, merging filtered QS dataset ADSL. necessary treatment start date TRTSDT prerequisite derivation variables Analysis Day ADY can programmed following article creating BDS dataset SDTM.","code":"data(\"admiral_adsl\") data(\"qs_ophtha\") adsl <- admiral_adsl qs <- qs_ophtha  qs <- qs %>% filter(QSTESTCD %in% c(\"VFQ1\", \"VFQ2\", \"VFQ3\", \"VFQ4\")) param_lookup <- tibble::tribble(   ~QSTESTCD, ~PARAMCD, ~PARAM, ~PARCAT1, ~PARCAT2,   \"VFQ1\", \"VFQ1\", \"Overall Health\", \"NEI VFQ-25\", \"Original Response\",   \"VFQ2\", \"VFQ2\", \"Eyesight in Both Eyes\", \"NEI VFQ-25\", \"Original Response\",   \"VFQ3\", \"VFQ3\", \"Worry About Eyesight\", \"NEI VFQ-25\", \"Original Response\",   \"VFQ4\", \"VFQ4\", \"Pain in and Around Eyes\", \"NEI VFQ-25\", \"Original Response\",   \"QR01\", \"QR01\", \"Recoded Item - 01\", \"NEI VFQ-25\", \"General 01\",   \"QR02\", \"QR02\", \"Recoded Item - 02\", \"NEI VFQ-25\", \"General 01\",   \"QR03\", \"QR03\", \"Recoded Item - 03\", \"NEI VFQ-25\", \"General 02\",   \"QR04\", \"QR04\", \"Recoded Item - 04\", \"NEI VFQ-25\", \"General 02\",   \"QSG01\", \"QSG01\", \"General Score 01\", \"NEI VFQ-25\", \"Averaged Result\",   \"QSG02\", \"QSG02\", \"General Score 02\", \"NEI VFQ-25\", \"Averaged Result\",   \"QBCSCORE\", \"QBCSCORE\", \"Composite Score\", \"NEI VFQ-25\", \"Averaged Result\" ) adsl_vars <- exprs(TRTSDT, TRTEDT, TRT01A, TRT01P)  advfq <- derive_vars_merged(   qs,   dataset_add = adsl,   new_vars = adsl_vars,   by_vars = exprs(STUDYID, USUBJID) )"},{"path":"https://pharmaverse.github.io/admiralophtha/articles/advfq.html","id":"aval","dir":"Articles","previous_headings":"Programming Workflow","what":"Derive Analysis Value for Existing Questions","title":"Creating ADVFQ","text":"derive analysis values use function admiral::derive_vars_merged_lookup() merges PARAMCD parameter lookup table. merges parameter QSTESTCD assigns AVAL AVALC.","code":"advfq <- advfq %>%   ## Add PARAMCD only - add PARAM etc later ----   derive_vars_merged_lookup(     dataset_add = param_lookup,     new_vars = exprs(PARAMCD),     by_vars = exprs(QSTESTCD)   ) %>%   ## Calculate AVAL and AVALC ----   mutate(     AVAL = QSSTRESN,     AVALC = QSORRES   )"},{"path":"https://pharmaverse.github.io/admiralophtha/articles/advfq.html","id":"parameters","dir":"Articles","previous_headings":"Programming Workflow","what":"Derive Parameters for Recoded Items and Summary Scores","title":"Creating ADVFQ","text":"included initial records QS, programmer next program new records parameters recode original questions. Run section code every question need recoding. gives example recoding one question. Next, programmer create summary records average recoded questions using admiral::derive_summary_records. example uses two recoded questions create average record.","code":"## QR01 Recoded Item 01 # set to 100 if [advfq.AVAL] = 1 # else set to 75 if [advfq.AVAL] = 2 # else set to 50 if [advfq.AVAL] = 3 # else set to 25 if [advfq.AVAL] = 4 # else set to 0 if [advfq.AVAL] = 5 advfq <- advfq %>%   derive_summary_records(     by_vars = exprs(STUDYID, USUBJID, !!!adsl_vars, PARAMCD, VISITNUM, VISIT),     filter = QSTESTCD == \"VFQ1\" & !is.na(AVAL),     analysis_var = AVAL,     summary_fun = identity,     set_values_to = exprs(PARAMCD = \"QR01\")   ) %>%   mutate(AVAL = ifelse(PARAMCD == \"QR01\",     case_when(       AVAL == 1 ~ 100,       AVAL == 2 ~ 75,       AVAL == 3 ~ 50,       AVAL == 4 ~ 25,       AVAL >= 5 ~ 0     ),     AVAL   )) ## Derive a new record as a summary record  ---- ## QSG01 General Score 01 # Average of QR01 and QR02 records advfq <- advfq %>%   derive_summary_records(     by_vars = exprs(STUDYID, USUBJID, !!!adsl_vars, VISITNUM, VISIT, ADT, ADY),     filter = PARAMCD %in% c(\"QR01\", \"QR02\") & !is.na(AVAL),     analysis_var = AVAL,     summary_fun = mean,     set_values_to = exprs(PARAMCD = \"QSG01\")   )"},{"path":"https://pharmaverse.github.io/admiralophtha/articles/advfq.html","id":"analysis","dir":"Articles","previous_headings":"Programming Workflow","what":"Derive Analysis Variables","title":"Creating ADVFQ","text":"finding ADaMs, analysis flag derived identify appropriate observation(s) use particular analysis subject multiple observations within particular timing period. situation, analysis flag (e.g. ANLxxFL) may used choose appropriate record analysis. flag may derived using admiral function admiral::derive_var_extreme_flag(). example, assume like choose latest value USUBJID, PARAMCD AVISIT. derive ASEQ using admiral::derive_var_obs_number() based observation number within dataset, additionally merge PARAM, PARCAT1 PARCAT2 using earlier lookup table.","code":"## ANL01FL: Flag last result within an AVISIT for post-baseline records ---- advfq <- advfq %>%   restrict_derivation(     derivation = derive_var_extreme_flag,     args = params(       new_var = ANL01FL,       by_vars = exprs(USUBJID, PARAMCD, AVISIT),       order = exprs(ADT, AVAL),       mode = \"last\"     ),     filter = !is.na(AVISITN) & ONTRTFL == \"Y\"   ) ## Get ASEQ and PARAM  ---- advfq <- advfq %>%   # Calculate ASEQ   derive_var_obs_number(     new_var = ASEQ,     by_vars = exprs(STUDYID, USUBJID),     order = exprs(PARAMCD, ADT, AVISITN, VISITNUM),     check_type = \"error\"   ) %>%   # Derive PARAM   derive_vars_merged(dataset_add = select(param_lookup, -QSTESTCD), by_vars = exprs(PARAMCD))"},{"path":"https://pharmaverse.github.io/admiralophtha/articles/advfq.html","id":"adslvars","dir":"Articles","previous_headings":"Programming Workflow","what":"Add ADSL Variables","title":"Creating ADVFQ","text":"analysis variables programmed, variables ADSL required merged dataset using admiral::derive_vars_merged.","code":"# Add all ADSL variables advfq <- advfq %>%   derive_vars_merged(     dataset_add = select(adsl, !!!negate_vars(adsl_vars)),     by_vars = exprs(STUDYID, USUBJID)   )"},{"path":[]},{"path":"https://pharmaverse.github.io/admiralophtha/articles/standards.html","id":"introduction","dir":"Articles","previous_headings":"","what":"Introduction","title":"Ophthalmology Standards","text":"Ophthalmology hugely diverse therapeutic area, endpoints conventions can differ study study - let alone across companies. Notwithstanding , exist cases alignment possible; page indexes occurrences admiralophtha suggests adoption certain standard way things. Applying standards means mandatory, help leveraging tools (templates, functions, etc.) provided admiralophtha well lower barrier entry programming study. Additionally, page can function guidance programmers starting dip feet ophthalmology ADaM programming.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/articles/standards.html","id":"dataset-subdivision","dir":"Articles","previous_headings":"Introduction","what":"Dataset Subdivision","title":"Ophthalmology Standards","text":"Due aforementioned high complexity diversity ophthalmology data, discouraged funnel records OE SDTM dataset single ADOE dataset, result overly complicated program/dataset pair. admiralophtha instead suggests following partition: ADOE general miscellaneous ophthalmology tests used efficacy programming. ADBCVA BCVA data - almost always constitute primary secondary endpoint require endpoint-related programming criterion flags. endpoints specific efficacy programming may required ADaM dataset (e.g. intraocular pressure data, ADIOP). ADVFQ Visual Functioning Questionnaire data. Subdividing ADaM datasets study ensure wherever custom efficacy programming required, automatically limited data interest. instance, study various endpoints form Gain x y letters relative baseline (similar) likely require criterion variable/flag pair (see Criterion Flag section detail). BCVA data stored ADOE, criterion variable/flag pairs blank irrelevant data dataset, save BCVA records. Conversely, collecting BCVA data ADBCVA ensures criterion variable/flag pairs relevant, resulting dataset readable.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/articles/standards.html","id":"criterion","dir":"Articles","previous_headings":"Introduction","what":"Criterion Flags","title":"Ophthalmology Standards","text":"admiralophtha suggests use criterion variable/flag pairs CRITx/CRITxFL possible endpoint programming. implemented correctly, transparent approach condition CRITxFL can clearly encoded CRITx, without view documentation. appropriate, condition CRITx represented programmatically rather words reduce possibility confusion. instance, endpoint Gain x y letters relative baseline, one set CRIT1 = \"x <= CHG <= y\". Note: Though allowable according ADaM standards, generally discouraged use criterion flag/variable pair one criterion across multiple parameters ADaM dataset, renders dataset confusing scrutinise. BCVA change endpoints, provides function derive_var_bcvacritxfl add en masse. Additionally, function automatically populates CRITx programmatic manner described .","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/articles/standards.html","id":"affected-eye-derivation","dir":"Articles","previous_headings":"Introduction","what":"Affected Eye Derivation","title":"Ophthalmology Standards","text":"admiralophtha function derive_var_afeye follows standard derivation: Set “EYES” Study Eye Selection [ADSL.STUDYEYE] missing, Laterality [xxLAT] equal “BILATERAL”. Else set “STUDY EYE” Study Eye Selection [ADSL.STUDYEYE] either “RIGHT” “LEFT”, matches Laterality [xxLAT] observation record. Else set “STUDY EYE” Study Eye Selection [ADSL.STUDYEYE] “BILATERAL”, Laterality [xxLAT] missing observation record. Else set “FELLOW EYE” Study Eye Selection [ADSL.STUDYEYE] either “RIGHT” “LEFT”, [xxLAT] missing match Laterality [xxLAT] observation record. Else set null. standard values Location [xxLOC] = “EYE” Laterality [xxLAT] = “LEFT”, “RIGHT”, “BILATERAL” study can updated inputs function, otherwise also expected AFEYE derived, warning returned values found.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/authors.html","id":null,"dir":"","previous_headings":"","what":"Authors","title":"Authors and Citation","text":"Edoardo Mancini. Author, maintainer. Ritika Aggarwal. Author. Jane Gao. Author. William Holmes. Author. Josie Jackson. Author. Sonali Jain. Author. Yuki Matsunaga. Author. Gordon Miller. Author. Rachel Linacre. Author. Lucy Palmen. Author. Nandini R Thampi. Author. Aldrich Salva. Author.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/authors.html","id":"citation","dir":"","previous_headings":"","what":"Citation","title":"Authors and Citation","text":"Mancini E, Aggarwal R, Gao J, Holmes W, Jackson J, Jain S, Matsunaga Y, Miller G, Linacre R, Palmen L, R Thampi N, Salva (2023). admiralophtha: ADaM R Asset Library - Ophthalmology. https://pharmaverse.github.io/admiralophtha/, https://github.com/pharmaverse/admiralophtha/.","code":"@Manual{,   title = {admiralophtha: ADaM in R Asset Library - Ophthalmology},   author = {Edoardo Mancini and Ritika Aggarwal and Jane Gao and William Holmes and Josie Jackson and Sonali Jain and Yuki Matsunaga and Gordon Miller and Rachel Linacre and Lucy Palmen and Nandini {R Thampi} and Aldrich Salva},   year = {2023},   note = {https://pharmaverse.github.io/admiralophtha/, https://github.com/pharmaverse/admiralophtha/}, }"},{"path":[]},{"path":"https://pharmaverse.github.io/admiralophtha/index.html","id":"purpose","dir":"","previous_headings":"","what":"Purpose","title":"ADaM in R Asset Library - Ophthalmology","text":"provide complementary (admiral) toolbox enables users develop ophthalmology disease area datasets endpoints.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/index.html","id":"installation","dir":"","previous_headings":"","what":"Installation","title":"ADaM in R Asset Library - Ophthalmology","text":"install latest development version package directly GitHub use following code:","code":"if (!requireNamespace(\"remotes\", quietly = TRUE)) {   install.packages(\"remotes\") } remotes::install_github(\"pharmaverse/admiralophtha\", ref = \"devel\")"},{"path":"https://pharmaverse.github.io/admiralophtha/index.html","id":"scope","dir":"","previous_headings":"","what":"Scope","title":"ADaM in R Asset Library - Ophthalmology","text":"Build toolbox re-usable functions utilities create Ophthalmology-specific ADaM datasets R modular manner. functions created based upon ADaM Implementation Guide aim facilitate programming ADaM dataset standards.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/index.html","id":"references-and-documentation","dir":"","previous_headings":"","what":"References and Documentation","title":"ADaM in R Asset Library - Ophthalmology","text":"Please refer {admiral} References Documentation.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/index.html","id":"r-versions","dir":"","previous_headings":"","what":"R Versions","title":"ADaM in R Asset Library - Ophthalmology","text":"’s summary strategy package related R versions: R versions developers users follow admiral core package. development devel branch admiral core used dependency. releasing new admiralophtha version must run using latest released admiral core version, .e., main branch admiral core.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/index.html","id":"contact","dir":"","previous_headings":"","what":"Contact","title":"ADaM in R Asset Library - Ophthalmology","text":"use following support communications user developer community: Slack - informal discussions, Q&building user community. don’t access, use link join pharmaverse Slack workspace GitHub Issues - direct feedback, enhancement requests raising bugs","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/index.html","id":"release-schedule","dir":"","previous_headings":"","what":"Release Schedule","title":"ADaM in R Asset Library - Ophthalmology","text":"first release (v. 0.1.0) came 13th March 2023. second release (v. 0.2.0) came 12th June 2023. third release (v. 0.3.0) came 18th September 2023. planning fourth release (v.1.0) December 11th 2023. objective 1.0 release admiralophtha provide package mature enough used part ADaM work ophthalmology study.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/admiralophtha-package.html","id":null,"dir":"Reference","previous_headings":"","what":"admiralophtha: ADaM in R Asset Library - Ophthalmology — admiralophtha-package","title":"admiralophtha: ADaM in R Asset Library - Ophthalmology — admiralophtha-package","text":"Aids programming Clinical Data Standards Interchange Consortium (CDISC) compliant Ophthalmology Analysis Data Model (ADaM) datasets R. ADaM datasets mandatory part New Drug Biologics License Application submitted United States Food Drug Administration (FDA). Analysis derivations implemented accordance \"Analysis Data Model Implementation Guide\" (CDISC Analysis Data Model Team, 2021, https://www.cdisc.org/standards/foundational/adam/adamig-v1-3-release-package).","code":""},{"path":[]},{"path":"https://pharmaverse.github.io/admiralophtha/reference/admiralophtha-package.html","id":"author","dir":"Reference","previous_headings":"","what":"Author","title":"admiralophtha: ADaM in R Asset Library - Ophthalmology — admiralophtha-package","text":"Maintainer: Edoardo Mancini edoardo.mancini@roche.com Authors: Ritika Aggarwal ritika.aggarwal@novartis.com Jane Gao jane.gao@roche.com William Holmes william.holmes@roche.com Josie Jackson josie.jackson@roche.com Sonali Jain sonali.jain@novartis.com Yuki Matsunaga yuki.matsunaga@novartis.com Gordon Miller gordon.miller@roche.com Rachel Linacre rachel.linacre@roche.com Lucy Palmen lucy.palmen@roche.com Nandini R Thampi nandini.rajendhiran@novartis.com Aldrich Salva salva.aldrich@gene.com","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/admiralophtha_adbcva.html","id":null,"dir":"Reference","previous_headings":"","what":"Best Corrected Visual Acuity Analysis Dataset — admiralophtha_adbcva","title":"Best Corrected Visual Acuity Analysis Dataset — admiralophtha_adbcva","text":"example Best Corrected Visual Acuity (BCVA) analysis dataset","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/admiralophtha_adbcva.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Best Corrected Visual Acuity Analysis Dataset — admiralophtha_adbcva","text":"","code":"admiralophtha_adbcva"},{"path":"https://pharmaverse.github.io/admiralophtha/reference/admiralophtha_adbcva.html","id":"format","dir":"Reference","previous_headings":"","what":"Format","title":"Best Corrected Visual Acuity Analysis Dataset — admiralophtha_adbcva","text":"object class tbl_df (inherits tbl, data.frame) 7672 rows 116 columns.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/admiralophtha_adbcva.html","id":"source","dir":"Reference","previous_headings":"","what":"Source","title":"Best Corrected Visual Acuity Analysis Dataset — admiralophtha_adbcva","text":"Derived OE ADSL datasets using {admiral}, {admiralophtha} (https://github.com/pharmaverse/admiralophtha/blob/main/inst/templates/ad_adbcva.R)","code":""},{"path":[]},{"path":"https://pharmaverse.github.io/admiralophtha/reference/admiralophtha_adoe.html","id":null,"dir":"Reference","previous_headings":"","what":"Ophthalmology Exam Analysis Dataset — admiralophtha_adoe","title":"Ophthalmology Exam Analysis Dataset — admiralophtha_adoe","text":"example Ophthalmology Exam Analysis dataset","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/admiralophtha_adoe.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Ophthalmology Exam Analysis Dataset — admiralophtha_adoe","text":"","code":"admiralophtha_adoe"},{"path":"https://pharmaverse.github.io/admiralophtha/reference/admiralophtha_adoe.html","id":"format","dir":"Reference","previous_headings":"","what":"Format","title":"Ophthalmology Exam Analysis Dataset — admiralophtha_adoe","text":"object class tbl_df (inherits tbl, data.frame) 7672 rows 98 columns.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/admiralophtha_adoe.html","id":"source","dir":"Reference","previous_headings":"","what":"Source","title":"Ophthalmology Exam Analysis Dataset — admiralophtha_adoe","text":"Derived OE ADSL datasets using {admiral}, {admiralophtha} (https://github.com/pharmaverse/admiralophtha/blob/main/inst/templates/ad_adoe.R)","code":""},{"path":[]},{"path":"https://pharmaverse.github.io/admiralophtha/reference/admiralophtha_advfq.html","id":null,"dir":"Reference","previous_headings":"","what":"Visual Function Questionnaire Analysis Dataset — admiralophtha_advfq","title":"Visual Function Questionnaire Analysis Dataset — admiralophtha_advfq","text":"example Visual Function Questionnaire (VFQ) analysis dataset","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/admiralophtha_advfq.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Visual Function Questionnaire Analysis Dataset — admiralophtha_advfq","text":"","code":"admiralophtha_advfq"},{"path":"https://pharmaverse.github.io/admiralophtha/reference/admiralophtha_advfq.html","id":"format","dir":"Reference","previous_headings":"","what":"Format","title":"Visual Function Questionnaire Analysis Dataset — admiralophtha_advfq","text":"object class tbl_df (inherits tbl, data.frame) 28798 rows 41 columns.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/admiralophtha_advfq.html","id":"source","dir":"Reference","previous_headings":"","what":"Source","title":"Visual Function Questionnaire Analysis Dataset — admiralophtha_advfq","text":"Derived ADSL QS datasets using {admiral}, {admiralophtha} (https://github.com/pharmaverse/admiralophtha/blob/main/inst/templates/ad_advfq.R)","code":""},{"path":[]},{"path":"https://pharmaverse.github.io/admiralophtha/reference/convert_etdrs_to_logmar.html","id":null,"dir":"Reference","previous_headings":"","what":"ETDRS --> LogMAR conversion — convert_etdrs_to_logmar","title":"ETDRS --> LogMAR conversion — convert_etdrs_to_logmar","text":"Convert ETDRS score LogMAR units","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/convert_etdrs_to_logmar.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"ETDRS --> LogMAR conversion — convert_etdrs_to_logmar","text":"","code":"convert_etdrs_to_logmar(value)"},{"path":"https://pharmaverse.github.io/admiralophtha/reference/convert_etdrs_to_logmar.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"ETDRS --> LogMAR conversion — convert_etdrs_to_logmar","text":"value object containing ETDRS score convert logMAR","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/convert_etdrs_to_logmar.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"ETDRS --> LogMAR conversion — convert_etdrs_to_logmar","text":"input value converted converted logMAR units","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/convert_etdrs_to_logmar.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"ETDRS --> LogMAR conversion — convert_etdrs_to_logmar","text":"ETDRS value converted logMAR logMAR = -0.02 * ETDRS + 1.7 Source conversion formula: Beck, R.W., et al. computerized method visual acuity testing. American Journal Ophthalmology, 135(2), pp.194–205. doi:https://doi.org/10.1016/s0002-9394(02)01825-1.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/convert_etdrs_to_logmar.html","id":"author","dir":"Reference","previous_headings":"","what":"Author","title":"ETDRS --> LogMAR conversion — convert_etdrs_to_logmar","text":"Rachel Linacre","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/convert_etdrs_to_logmar.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"ETDRS --> LogMAR conversion — convert_etdrs_to_logmar","text":"","code":"library(tibble) library(dplyr) #>  #> Attaching package: ‘dplyr’ #> The following objects are masked from ‘package:stats’: #>  #>     filter, lag #> The following objects are masked from ‘package:base’: #>  #>     intersect, setdiff, setequal, union library(admiral) library(admiraldev) #>  #> Attaching package: ‘admiraldev’ #> The following objects are masked from ‘package:dplyr’: #>  #>     anti_join, filter_if, inner_join, left_join  adbcva <- tribble(   ~STUDYID, ~USUBJID, ~AVAL,   \"XXX001\", \"P01\", 5,   \"XXX001\", \"P02\", 10,   \"XXX001\", \"P03\", 15,   \"XXX001\", \"P04\", 20,   \"XXX001\", \"P05\", 25 )  adbcva <- adbcva %>% mutate(AVAL = convert_etdrs_to_logmar(AVAL))"},{"path":"https://pharmaverse.github.io/admiralophtha/reference/convert_logmar_to_etdrs.html","id":null,"dir":"Reference","previous_headings":"","what":"LogMAR --> ETDRS conversion — convert_logmar_to_etdrs","title":"LogMAR --> ETDRS conversion — convert_logmar_to_etdrs","text":"Convert LogMAR score ETDRS units","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/convert_logmar_to_etdrs.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"LogMAR --> ETDRS conversion — convert_logmar_to_etdrs","text":"","code":"convert_logmar_to_etdrs(value)"},{"path":"https://pharmaverse.github.io/admiralophtha/reference/convert_logmar_to_etdrs.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"LogMAR --> ETDRS conversion — convert_logmar_to_etdrs","text":"value object containing logMAR score convert ETDRS","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/convert_logmar_to_etdrs.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"LogMAR --> ETDRS conversion — convert_logmar_to_etdrs","text":"input value converted ETDRS units","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/convert_logmar_to_etdrs.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"LogMAR --> ETDRS conversion — convert_logmar_to_etdrs","text":"logMAR value converted ETDRS ETDRS = -(logMAR - 1.7) / 0.02 Source conversion formula: Beck, R.W., et al. computerized method visual acuity testing. American Journal Ophthalmology, 135(2), pp.194–205. doi:https://doi.org/10.1016/s0002-9394(02)01825-1.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/convert_logmar_to_etdrs.html","id":"author","dir":"Reference","previous_headings":"","what":"Author","title":"LogMAR --> ETDRS conversion — convert_logmar_to_etdrs","text":"Nandini R Thampi","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/convert_logmar_to_etdrs.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"LogMAR --> ETDRS conversion — convert_logmar_to_etdrs","text":"","code":"library(tibble) library(dplyr) library(admiral)  oe <- tribble(   ~STUDYID, ~USUBJID, ~OETESTCD, ~OEMETHOD, ~OESTRESN,   \"XXX001\", \"P01\", \"VACSCORE\", \"logMAR EYE CHART\", 1.08,   \"XXX001\", \"P02\", \"VACSCORE\", \"logMAR EYE CHART\", 1.66,   \"XXX001\", \"P03\", \"VACSCORE\", \"logMAR EYE CHART\", 1.60,   \"XXX001\", \"P04\", \"VACSCORE\", \"ETDRS EYE CHART\", 57,   \"XXX001\", \"P05\", \"VACSCORE\", \"ETDRS EYE CHART\", 1 )  adbcva <- oe %>%   filter(OETESTCD == \"VACSCORE\" & toupper(OEMETHOD) == \"LOGMAR EYE CHART\") %>%   mutate(OESTRESN = convert_logmar_to_etdrs(OESTRESN))"},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_afeye.html","id":null,"dir":"Reference","previous_headings":"","what":"Derive Affected Eye — derive_var_afeye","title":"Derive Affected Eye — derive_var_afeye","text":"Derive Affected Eye (AFEYE) occurrence datasets","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_afeye.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Derive Affected Eye — derive_var_afeye","text":"","code":"derive_var_afeye(   dataset_occ,   loc_var,   lat_var,   loc_vals = \"EYE\",   lat_vals = c(\"LEFT\", \"RIGHT\", \"BILATERAL\") )"},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_afeye.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Derive Affected Eye — derive_var_afeye","text":"dataset_occ Input Occurence dataset loc_var Location variable lat_var Laterality variable loc_vals xxLOCvalues AFEYE derived lat_vals xxLATvalues AFEYE derived","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_afeye.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Derive Affected Eye — derive_var_afeye","text":"input occurrence dataset Affected Eye (AFEYE) added.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_afeye.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Derive Affected Eye — derive_var_afeye","text":"Affected Eye derived occurrence dataset using laterality Study Eye. assumes Study Eye already added ADSL.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_afeye.html","id":"author","dir":"Reference","previous_headings":"","what":"Author","title":"Derive Affected Eye — derive_var_afeye","text":"Lucy Palmen","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_afeye.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Derive Affected Eye — derive_var_afeye","text":"","code":"library(tibble) library(admiral)  adae <- tribble(   ~STUDYID, ~USUBJID, ~STUDYEYE, ~AELOC, ~AELAT,   \"XXX001\", \"P01\", \"RIGHT\", \"EYE\", \"RIGHT\",   \"XXX001\", \"P01\", \"RIGHT\", \"EYE\", \"LEFT\",   \"XXX001\", \"P01\", \"RIGHT\", \"EYE\", \"\",   \"XXX001\", \"P01\", \"RIGHT\", \"\", \"RIGHT\",   \"XXX001\", \"P02\", \"LEFT\", \"\", \"\",   \"XXX001\", \"P02\", \"LEFT\", \"EYE\", \"LEFT\",   \"XXX001\", \"P04\", \"BILATERAL\", \"EYE\", \"RIGHT\",   \"XXX001\", \"P05\", \"RIGHT\", \"EYE\", \"RIGHT\",   \"XXX001\", \"P05\", \"RIGHT\", \"EYE\", \"BILATERAL\",   \"XXX001\", \"P06\", \"BILATERAL\", \"\", \"\",   \"XXX001\", \"P06\", \"BILATERAL\", \"\", \"RIGHT\",   \"XXX001\", \"P07\", \"BILATERAL\", \"EYE\", \"BILATERAL\",   \"XXX001\", \"P08\", \"\", \"EYE\", \"BILATERAL\",   \"XXX001\", \"P09\", \"NONSENSE\", \"EYE\", \"BILATERAL\",   \"XXX001\", \"P09\", \"BILATERAL\", \"EYE\", \"NONSENSE\",   \"XXX001\", \"P09\", \"BILATERAL\", \"NONSENSE\", \"BILATERAL\",   \"XXX001\", \"P10\", \"RIGHT\", \"EYE\", \"BOTH\" )  adae <- derive_var_afeye(adae, AELOC, AELAT) #> Warning: Warning: value not in lat_vals #> Warning: Warning: value not in loc_vals #> Warning: Warning: STUDYEYE is expected to be 'LEFT', 'RIGHT' or 'BILATERAL'"},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_bcvacritxfl.html","id":null,"dir":"Reference","previous_headings":"","what":"Adds CRITx/CRITxFL pairs to BCVA dataset — derive_var_bcvacritxfl","title":"Adds CRITx/CRITxFL pairs to BCVA dataset — derive_var_bcvacritxfl","text":"Adds criterion variables CRITx corresponding flags CRITxFL dataset containing BCVA records","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_bcvacritxfl.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Adds CRITx/CRITxFL pairs to BCVA dataset — derive_var_bcvacritxfl","text":"","code":"derive_var_bcvacritxfl(   dataset,   crit_var,   bcva_ranges = NULL,   bcva_uplims = NULL,   bcva_lowlims = NULL,   additional_text = \"\",   critxfl_index = NULL )"},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_bcvacritxfl.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Adds CRITx/CRITxFL pairs to BCVA dataset — derive_var_bcvacritxfl","text":"dataset Input dataset containing BCVA data (usually ADBCVA). crit_var Variable respect CRITx/CRITxFL derived (usually CHG AVAL). bcva_ranges List containing one numeric vectors length 2. vector c(,b) bcva_ranges, pair variables CRITx, CRITxFL created condition: <=  crit_var <= b. criterion flags type required, leave NULL. bcva_uplims List containing one numeric elements. element bcva_uplims, pair variables CRITx, CRITxFL created condition: crit_var <= . criterion flags type required, leave NULL. bcva_lowlims List containing one numeric elements. element b bcva_lowlims, pair variables CRITx, CRITxFL created condition: crit_var >= b. criterion flags type required, leave NULL. additional_text string containing additional text append CRITx critxfl_index positive integer detailing first value x use CRITxFL. supplied, function takes first available value x, counting x = 1.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_bcvacritxfl.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Adds CRITx/CRITxFL pairs to BCVA dataset — derive_var_bcvacritxfl","text":"input BCVA dataset additional column pairsCRITx, CRITxFL.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_bcvacritxfl.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Adds CRITx/CRITxFL pairs to BCVA dataset — derive_var_bcvacritxfl","text":"function works calling derive_var_bcvacritxfl() elements bcva_ranges, bcva_uplims bcva_lowlims. NOTE: crit_var equal NA, resulting criterion flag also marked NA.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_bcvacritxfl.html","id":"author","dir":"Reference","previous_headings":"","what":"Author","title":"Adds CRITx/CRITxFL pairs to BCVA dataset — derive_var_bcvacritxfl","text":"Edoardo Mancini","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_bcvacritxfl.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Adds CRITx/CRITxFL pairs to BCVA dataset — derive_var_bcvacritxfl","text":"","code":"library(tibble) library(admiral) library(admiraldev)  adbcva1 <- tribble(   ~STUDYID, ~USUBJID, ~AVISIT, ~BASETYPE, ~PARAMCD, ~CHG,   \"XXX001\", \"P01\", \"BASELINE\", \"LAST\", \"SBCVA\", 0,   \"XXX001\", \"P01\", \"WEEK 2\", \"LAST\", \"FBCVA\", 2,   \"XXX001\", \"P02\", \"BASELINE\", \"LAST\", \"SBCVA\", -13,   \"XXX001\", \"P02\", \"WEEK 2\", \"LAST\", \"FBCVA\", 5,   \"XXX001\", \"P03\", \"BASELINE\", \"LAST\", \"SBCVA\", NA,   \"XXX001\", \"P03\", \"WEEK 2\", \"LAST\", \"FBCVA\", 17 )  derive_var_bcvacritxfl(   dataset = adbcva1,   crit_var = exprs(CHG),   bcva_ranges = list(c(0, 5), c(-5, -1), c(10, 15)),   bcva_uplims = list(5, 10),   bcva_lowlims = list(8),   additional_text = \"\" ) #> # A tibble: 6 × 18 #>   STUDYID USUBJID AVISIT   BASETYPE PARAMCD   CHG CRIT1    CRIT1FL CRIT2 CRIT2FL #>   <chr>   <chr>   <chr>    <chr>    <chr>   <dbl> <chr>    <chr>   <chr> <chr>   #> 1 XXX001  P01     BASELINE LAST     SBCVA       0 0 <= CH… Y       -5 <… N       #> 2 XXX001  P01     WEEK 2   LAST     FBCVA       2 0 <= CH… Y       -5 <… N       #> 3 XXX001  P02     BASELINE LAST     SBCVA     -13 0 <= CH… N       -5 <… N       #> 4 XXX001  P02     WEEK 2   LAST     FBCVA       5 0 <= CH… Y       -5 <… N       #> 5 XXX001  P03     BASELINE LAST     SBCVA      NA 0 <= CH… NA      -5 <… NA      #> 6 XXX001  P03     WEEK 2   LAST     FBCVA      17 0 <= CH… N       -5 <… N       #> # ℹ 8 more variables: CRIT3 <chr>, CRIT3FL <chr>, CRIT4 <chr>, CRIT4FL <chr>, #> #   CRIT5 <chr>, CRIT5FL <chr>, CRIT6 <chr>, CRIT6FL <chr>  adbcva2 <- tribble(   ~STUDYID, ~USUBJID, ~AVISIT, ~BASETYPE, ~PARAMCD, ~AVAL, ~CHG,   \"XXX001\", \"P01\", \"BASELINE\", \"LAST\", \"SBCVA\", 4, NA,   \"XXX001\", \"P01\", \"BASELINE\", \"LAST\", \"SBCVA\", 6, NA,   \"XXX001\", \"P01\", \"AVERAGE BASELINE\", \"AVERAGE\", \"SBCVA\", 5, NA,   \"XXX001\", \"P01\", \"WEEK 2\", \"LAST\", \"SBCVA\", -3, NA,   \"XXX001\", \"P01\", \"WEEK 4\", \"LAST\", \"SBCVA\", -10, NA,   \"XXX001\", \"P01\", \"WEEK 6\", \"LAST\", \"SBCVA\", 12, NA,   \"XXX001\", \"P01\", \"WEEK 2\", \"AVERAGE\", \"SBCVA\", -2, -7,   \"XXX001\", \"P01\", \"WEEK 4\", \"AVERAGE\", \"SBCVA\", 6, 1,   \"XXX001\", \"P01\", \"WEEK 6\", \"AVERAGE\", \"SBCVA\", 3, -2 )  restrict_derivation(   adbcva2,   derivation = derive_var_bcvacritxfl,   args = params(     crit_var = exprs(CHG),     bcva_ranges = list(c(0, 5), c(-10, 0)),     bcva_lowlims = list(5),     additional_text = \" (AVERAGE)\"   ),   filter = PARAMCD %in% c(\"SBCVA\", \"FBCVA\") & BASETYPE == \"AVERAGE\" ) #> # A tibble: 9 × 13 #>   STUDYID USUBJID AVISIT        BASETYPE PARAMCD  AVAL   CHG CRIT1 CRIT1FL CRIT2 #>   <chr>   <chr>   <chr>         <chr>    <chr>   <dbl> <dbl> <chr> <chr>   <chr> #> 1 XXX001  P01     AVERAGE BASE… AVERAGE  SBCVA       5    NA 0 <=… NA      -10 … #> 2 XXX001  P01     WEEK 2        AVERAGE  SBCVA      -2    -7 0 <=… N       -10 … #> 3 XXX001  P01     WEEK 4        AVERAGE  SBCVA       6     1 0 <=… Y       -10 … #> 4 XXX001  P01     WEEK 6        AVERAGE  SBCVA       3    -2 0 <=… N       -10 … #> 5 XXX001  P01     BASELINE      LAST     SBCVA       4    NA NA    NA      NA    #> 6 XXX001  P01     BASELINE      LAST     SBCVA       6    NA NA    NA      NA    #> 7 XXX001  P01     WEEK 2        LAST     SBCVA      -3    NA NA    NA      NA    #> 8 XXX001  P01     WEEK 4        LAST     SBCVA     -10    NA NA    NA      NA    #> 9 XXX001  P01     WEEK 6        LAST     SBCVA      12    NA NA    NA      NA    #> # ℹ 3 more variables: CRIT2FL <chr>, CRIT3 <chr>, CRIT3FL <chr>"},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_bcvacritxfl_util.html","id":null,"dir":"Reference","previous_headings":"","what":"Add CRITx/CRITxFL pair to BCVA dataset — derive_var_bcvacritxfl_util","title":"Add CRITx/CRITxFL pair to BCVA dataset — derive_var_bcvacritxfl_util","text":"Helper function derive_var_bcvacritxfl() adds criterion variable CRITx corresponding flag CRITxFL dataset containing BCVA records","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_bcvacritxfl_util.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Add CRITx/CRITxFL pair to BCVA dataset — derive_var_bcvacritxfl_util","text":"","code":"derive_var_bcvacritxfl_util(   dataset,   crit_var,   critx_text,   critxfl_cond,   counter,   bcva_range = NULL,   bcva_uplim = NULL,   bcva_lowlim = NULL )"},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_bcvacritxfl_util.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Add CRITx/CRITxFL pair to BCVA dataset — derive_var_bcvacritxfl_util","text":"dataset Input dataset (usually ADBCVA). crit_var Variable respect CRITx/CRITxFL derived (usually CHG AVAL). critx_text String containing text CRITx variable. critxfl_cond String containing R code detailing criterion satisfied CRITxFL variable equal \"Y\". counter Integer detailing value x use CRITxFL. bcva_range Numeric vector length two detailing lower upper change BCVA limits (bcva_range called critxfl_cond criterion stipulates change BCVA lie inside range). bcva_uplim Numeric value detailing highest change BCVA limit (bcva_uplim called critxfl_cond criterion stipulates change BCVA lie upper limit). bcva_lowlim Numeric value detailing lowest change BCVA limit (bcva_lowlim called critxfl_cond criterion stipulates change BCVA lie lower limit).","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_bcvacritxfl_util.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Add CRITx/CRITxFL pair to BCVA dataset — derive_var_bcvacritxfl_util","text":"input BCVA dataset additional columns CRITx, CRITxFL.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_bcvacritxfl_util.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Add CRITx/CRITxFL pair to BCVA dataset — derive_var_bcvacritxfl_util","text":"criterion change BCVA CRITxFL can three types: (1) value lies within range; <= crit_var <= b; (2) value upper limit; crit_var <= ; (3) value lower limit; b <= crit_var. (1), bcva_range must specified function; (2), bcva_uplim; (3) bcva_lowlim. necessary supply least one three arguments. NOTE: crit_var equal NA, resulting criterion flag also marked NA.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_bcvacritxfl_util.html","id":"author","dir":"Reference","previous_headings":"","what":"Author","title":"Add CRITx/CRITxFL pair to BCVA dataset — derive_var_bcvacritxfl_util","text":"Edoardo Mancini","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_studyeye.html","id":null,"dir":"Reference","previous_headings":"","what":"Derive Study Eye — derive_var_studyeye","title":"Derive Study Eye — derive_var_studyeye","text":"Derive Study Eye (STUDYEYE) ADSL dataset","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_studyeye.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Derive Study Eye — derive_var_studyeye","text":"","code":"derive_var_studyeye(dataset_adsl, dataset_sc, sctestcd_value = \"FOCID\")"},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_studyeye.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Derive Study Eye — derive_var_studyeye","text":"dataset_adsl ADSL input dataset dataset_sc SC input dataset sctestcd_value SCTESTCD value flagging Study Eye selection records. Default: \"FOCID\".","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_studyeye.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Derive Study Eye — derive_var_studyeye","text":"input ADSL dataset additional column named STUDYEYE","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_studyeye.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Derive Study Eye — derive_var_studyeye","text":"Study Eye derived ADSL using \"Study Eye selection\" records SC SDTM dataset.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_studyeye.html","id":"author","dir":"Reference","previous_headings":"","what":"Author","title":"Derive Study Eye — derive_var_studyeye","text":"Edoardo Mancini","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_studyeye.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Derive Study Eye — derive_var_studyeye","text":"","code":"library(tibble) library(admiral)  adsl <- tribble(   ~STUDYID, ~USUBJID,   \"XXX001\", \"P01\",   \"XXX001\", \"P02\",   \"XXX001\", \"P03\",   \"XXX001\", \"P04\",   \"XXX001\", \"P05\" )  sc <- tribble(   ~STUDYID, ~USUBJID, ~SCTESTCD, ~SCSTRESC,   \"XXX001\", \"P01\", \"FOCID\", \"OS\",   \"XXX001\", \"P01\", \"ACOHORT\", \"COHORT1\",   \"XXX001\", \"P02\", \"FOCID\", \"OD\",   \"XXX001\", \"P02\", \"ACOHORT\", \"COHORT3\",   \"XXX001\", \"P04\", \"FOCID\", \"OU\",   \"XXX001\", \"P05\", \"FOCID\", \"OD\",   \"XXX001\", \"P06\", \"FOCID\", \"OS\" )  derive_var_studyeye(adsl, sc) #> # A tibble: 5 × 3 #>   STUDYID USUBJID STUDYEYE    #>   <chr>   <chr>   <chr>       #> 1 XXX001  P01     \"LEFT\"      #> 2 XXX001  P02     \"RIGHT\"     #> 3 XXX001  P03     \"\"          #> 4 XXX001  P04     \"BILATERAL\" #> 5 XXX001  P05     \"RIGHT\""}]
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(Don’t include brackets!) text enclosed appropriate comment syntax file format. also recommend file class name description purpose included “printed page” copyright notice easier identification within third-party archives.","code":"Copyright 2021 F. Hoffmann-La Roche AG and GlaxoSmithKline LLC  Licensed under the Apache License, Version 2.0 (the \"License\"); you may not use this file except in compliance with the License. You may obtain a copy of the License at    http://www.apache.org/licenses/LICENSE-2.0  Unless required by applicable law or agreed to in writing, software distributed under the License is distributed on an \"AS IS\" BASIS, WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. See the License for the specific language governing permissions and limitations under the License."},{"path":"https://pharmaverse.github.io/admiralophtha/articles/adbcva.html","id":"introduction","dir":"Articles","previous_headings":"","what":"Introduction","title":"Creating ADBCVA","text":"article describes creating ADBCVA ADaM Best-Corrected Visual Acuity (BCVA) data ophthalmology endpoints. used conjunction article creating BDS dataset SDTM. , derivations processes specific ADBCVA absent, user invited consult aforementioned article guidance. Note: examples assume CDISC SDTM /ADaM format input unless otherwise specified.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/articles/adbcva.html","id":"dataset-contents","dir":"Articles","previous_headings":"Introduction","what":"Dataset Contents","title":"Creating ADBCVA","text":"name ADBCVA implies, admiralophtha suggests populate ADBCVA solely BCVA records OE SDTM.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/articles/adbcva.html","id":"required-packages","dir":"Articles","previous_headings":"Introduction","what":"Required Packages","title":"Creating ADBCVA","text":"examples vignette require following packages.","code":"library(dplyr) library(admiral) library(pharmaversesdtm) library(admiraldev) library(admiralophtha)"},{"path":"https://pharmaverse.github.io/admiralophtha/articles/adbcva.html","id":"programming-workflow","dir":"Articles","previous_headings":"","what":"Programming Workflow","title":"Creating ADBCVA","text":"Initial Set ADBCVA Deriving LogMAR Score Parameters Derivations Standard BDS Variables Deriving Analysis Value Categories Snellen Scores Deriving Criterion Flags BCVA Change Additional Notes Example Script","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/articles/adbcva.html","id":"setup","dir":"Articles","previous_headings":"Programming Workflow","what":"Initial set up of ADBCVA","title":"Creating ADBCVA","text":"BDS ADaM datasets, one start OE SDTM, BCVA records interest. purposes next two sections, shall using admiral OE ADSL test data. also require lookup table mapping parameter codes. Note: simulate ophthalmology study, add randomly generated STUDYEYE variable ADSL, practice STUDYEYE already derived using derive_var_studyeye(). Following setup, programmer can start constructing ADBCVA. first step subset OE BCVA parameters merge ADSL. required two reasons: firstly, STUDYEYE crucial mapping AFEYE PARAMCD’s. Secondly, treatment start date (TRTSDT) also prerequisite derivation variables Analysis Day (ADY). next item business derive AVAL, AVALU, DTYPE. example, due small number parameters derivation trivial. AFEYE also created step using function derive_var_afeye(). Moving forwards, PARAM PARAMCD can assigned using derive_vars_merged() admiral lookup table param_lookup generated .","code":"data(\"oe_ophtha\") data(\"admiral_adsl\")  # Add STUDYEYE to ADSL to simulate an ophtha dataset adsl <- admiral_adsl %>%   as.data.frame() %>%   mutate(STUDYEYE = sample(c(\"LEFT\", \"RIGHT\"), n(), replace = TRUE)) %>%   convert_blanks_to_na()  oe <- convert_blanks_to_na(oe_ophtha) %>%   ungroup()  # ---- Lookup table ---- param_lookup <- tibble::tribble(   ~OETESTCD, ~OECAT, ~OESCAT, ~AFEYE, ~PARAMCD, ~PARAM, ~PARAMN,   \"VACSCORE\", \"BEST CORRECTED VISUAL ACUITY\", \"OVERALL EVALUATION\", \"Study Eye\", \"SBCVA\", \"Study Eye Visual Acuity Score (letters)\", 1, # nolint   \"VACSCORE\", \"BEST CORRECTED VISUAL ACUITY\", \"OVERALL EVALUATION\", \"Fellow Eye\", \"FBCVA\", \"Fellow Eye Visual Acuity Score (letters)\", 2, # nolint ) adsl_vars <- exprs(TRTSDT, TRTEDT, TRT01A, TRT01P, STUDYEYE)  adbcva <- oe %>%   filter(     OETESTCD %in% c(\"VACSCORE\")   ) %>%   derive_vars_merged(     dataset_add = adsl,     new_vars = adsl_vars,     by_vars = exprs(STUDYID, USUBJID)   ) adbcva <- adbcva %>%   mutate(     AVAL = OESTRESN,     AVALU = \"letters\",     DTYPE = NA_character_   ) %>%   derive_var_afeye(OELOC, OELAT) adbcva <- adbcva %>%   derive_vars_merged(     dataset_add = param_lookup,     new_vars = exprs(PARAM, PARAMCD),     by_vars = exprs(OETESTCD, AFEYE),     filter_add = PARAMCD %in% c(\"SBCVA\", \"FBCVA\")   )"},{"path":"https://pharmaverse.github.io/admiralophtha/articles/adbcva.html","id":"logmar","dir":"Articles","previous_headings":"Programming Workflow","what":"Deriving LogMAR Score Parameters","title":"Creating ADBCVA","text":"Often ADBCVA datasets contain derived records BCVA LogMAR units. can easily achieved follows using derive_param_computed(). conversion units done using convert_etdrs_to_logmar(). Two separate calls required due parameters split study fellow eye. extra parameters added, records end dataset now present, AVALC day/date variables ADY ADT can derived. Importantly, calls derive_param_computed() list SDTM variables VISIT, VISITNUM, OEDY OEDTC by_vars function. necessary derive ADaM variables AVISIT ADY successive steps. ADaM variables require derived, SDTM variables set missing derived records, per ADaM standards:","code":"adbcva <- adbcva %>%   derive_param_computed(     by_vars = c(exprs(STUDYID, USUBJID, VISIT, VISITNUM, OEDY, OEDTC), adsl_vars),     parameters = c(\"SBCVA\"),     analysis_value = convert_etdrs_to_logmar(AVAL.SBCVA),     set_values_to = exprs(       PARAMCD = \"SBCVALOG\",       PARAM = \"Study Eye Visual Acuity LogMAR Score\",       DTYPE = \"DERIVED\",       AVALU = \"LogMAR\"     )   ) %>%   derive_param_computed(     by_vars = c(exprs(STUDYID, USUBJID, VISIT, OEDY, OEDTC), adsl_vars),     parameters = c(\"FBCVA\"),     analysis_value = convert_etdrs_to_logmar(AVAL.FBCVA),     set_values_to = exprs(       PARAMCD = \"FBCVALOG\",       PARAM = \"Fellow Eye Visual Acuity LogMAR Score\",       DTYPE = \"DERIVED\",       AVALU = \"LogMAR\"     )   ) %>%   mutate(AVALC = as.character(AVAL)) %>%   derive_vars_dt(     new_vars_prefix = \"A\",     dtc = OEDTC,     flag_imputation = \"none\"   ) %>%   derive_vars_dy(reference_date = TRTSDT, source_vars = exprs(ADT)) #> Warning: The `analysis_value` argument of `derive_param_computed()` is deprecated as of #> admiral 0.12.0. #> ℹ Please use the `set_values_to` argument instead. #> This warning is displayed once every 8 hours. #> Call `lifecycle::last_lifecycle_warnings()` to see where this warning was #> generated. adbcva <- adbcva %>%   mutate(     VISIT = ifelse(PARAMCD %in% c(\"SBCVALOG\", \"FBCVALOG\"), NA_character_, VISIT),     VISITNUM = ifelse(PARAMCD %in% c(\"SBCVALOG\", \"FBCVALOG\"), NA, VISITNUM),     OEDY = ifelse(PARAMCD %in% c(\"SBCVALOG\", \"FBCVALOG\"), NA, OEDY),     OEDTC = ifelse(PARAMCD %in% c(\"SBCVALOG\", \"FBCVALOG\"), NA_character_, OEDTC)   )"},{"path":"https://pharmaverse.github.io/admiralophtha/articles/adbcva.html","id":"further","dir":"Articles","previous_headings":"Programming Workflow","what":"Further Derivations of Standard BDS Variables","title":"Creating ADBCVA","text":"user invited consult article creating BDS dataset SDTM learn add standard BDS variables ADBCVA. Henceforth, purposes article, following sections use ADBCVA dataset generated corresponding admiralophtha template program starting point. Note: dataset already comes criterion flags analysis value categorisation variables, illustration purposes removed.","code":"data(\"admiralophtha_adbcva\")  adbcva <- admiralophtha_adbcva %>%   select(-starts_with(\"CRIT\"), -starts_with(\"AVALCA\"))"},{"path":"https://pharmaverse.github.io/admiralophtha/articles/adbcva.html","id":"avalcats","dir":"Articles","previous_headings":"Programming Workflow","what":"Deriving Analysis Value Categories for Snellen Scores","title":"Creating ADBCVA","text":"ophthalmology studies may desire subdivide BCVA records according Snellen category fall (eg, 20/320, 20/100, 20/20 etc). best done use AVALCATx/AVALCAxN variable pairs. Currently, admiralophtha provide specific functionality create AVALCATx/AVALCAxN pairs, although may included future releases package. current toolset, suggested approach derive variables : Create lookup table assigns numeric equivalents (.e. AVALCAxN) Snellen categories. Create format function map AVAL numeric category. Add AVALCAxN mutate statement using format function. Add AVALCATx using derive_vars_merged combination lookup table. resulting output shown (limited first patient ):","code":"avalcat_lookup <- tibble::tribble(   ~PARAMCD, ~AVALCA1N, ~AVALCAT1,   \"SBCVA\", 1000, \"< 20/800\",   \"SBCVA\", 800, \"20/800\",   \"SBCVA\", 640, \"20/640\",   \"SBCVA\", 500, \"20/500\",   \"SBCVA\", 400, \"20/400\",   \"SBCVA\", 320, \"20/320\",   \"SBCVA\", 250, \"20/250\",   \"SBCVA\", 200, \"20/200\",   \"SBCVA\", 160, \"20/160\",   \"SBCVA\", 125, \"20/125\",   \"SBCVA\", 100, \"20/100\",   \"SBCVA\", 80, \"20/80\",   \"SBCVA\", 63, \"20/63\",   \"SBCVA\", 50, \"20/50\",   \"SBCVA\", 40, \"20/40\",   \"SBCVA\", 32, \"20/32\",   \"SBCVA\", 25, \"20/25\",   \"SBCVA\", 20, \"20/20\",   \"SBCVA\", 16, \"20/16\",   \"SBCVA\", 12, \"20/12\",   \"SBCVA\", 1, \"> 20/12\", )  avalcat_lookup <- avalcat_lookup %>%   mutate(PARAMCD = \"FBCVA\") %>%   rbind(avalcat_lookup)  format_avalcat1n <- function(param, aval) {   case_when(     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 0 & aval <= 3 ~ 1000,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 4 & aval <= 8 ~ 800,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 9 & aval <= 13 ~ 640,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 14 & aval <= 18 ~ 500,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 19 & aval <= 23 ~ 400,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 24 & aval <= 28 ~ 320,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 29 & aval <= 33 ~ 250,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 34 & aval <= 38 ~ 200,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 39 & aval <= 43 ~ 160,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 44 & aval <= 48 ~ 125,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 49 & aval <= 53 ~ 100,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 54 & aval <= 58 ~ 80,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 59 & aval <= 63 ~ 63,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 64 & aval <= 68 ~ 50,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 69 & aval <= 73 ~ 40,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 74 & aval <= 78 ~ 32,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 79 & aval <= 83 ~ 25,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 84 & aval <= 88 ~ 20,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 89 & aval <= 93 ~ 16,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 94 & aval <= 97 ~ 12,     param %in% c(\"SBCVA\", \"FBCVA\") & aval >= 98 ~ 1   ) }  adbcva <- adbcva %>%   mutate(AVALCA1N = format_avalcat1n(param = PARAMCD, aval = AVAL)) %>%   derive_vars_merged(     avalcat_lookup,     by = exprs(PARAMCD, AVALCA1N)   )"},{"path":"https://pharmaverse.github.io/admiralophtha/articles/adbcva.html","id":"critflags","dir":"Articles","previous_headings":"Programming Workflow","what":"Deriving Criterion Flags for BCVA Change","title":"Creating ADBCVA","text":"admiralophtha suggests use criterion flag variable pairs (CRITx/CRITxFL) program BCVA endpoints Avoiding loss x letters Gain y letters Gain x y letters (relative baseline basetypes). package provides function derive_var_bcvacritxfl() program endpoints efficiently consistently. terms logic apply variable CHG, endpoints fall three classes, can represented inequalities: Class 1: CHG value lying inside range, <= CHG <= b. Class 2: CHG value upper limit, CHG <= . Class 3: CHG value lower limit, CHG => b. using derive_var_bcvacritxfl(), ADaM programmer can implement three types endpoint . achieved feeding appropriate ranges, upper limits lower limits bcva_ranges, bcva_uplims bcva_lowlims arguments function. instance, let’s suppose endpoints interest : Gain 5 10 letters relative baseline (Class 1: 5 <= CHG <= 10) Gain 25 letters fewer relative baseline (Class 2: CHG <= 25) Loss 5 letters relative baseline (Class 2: CHG <= -5) Gain 15 letters relative baseline (Class 3: CHG >= 15) Loss 10 letters fewer relative baseline (Class 3: CHG >= -10). , following call implement criterion variable/flag pairs endpoints . CRITx variables automatically encode correct inequality. Note restrict_derivation() wrapped around call derive variables relevant parameters. way, filter argument can altered restrict derivation relevant records. Note also argument crit_var = exprs(CHG) specified criterion flags derived respect correct variable. resulting output shown (limited first patient ): also possible assign significance “x” CRITxFL. instance, one designate criterion flags Class 1 CRIT1yFL, Class 2 CRIT2yFL, Class 3 CRIT3yFL. argument critxfl_index allows simple implementation conjunction three separate calls derive_var_bcvacritxfl():","code":"adbcva <- adbcva %>% restrict_derivation(   derivation = derive_var_bcvacritxfl,   args = params(     crit_var = exprs(CHG),     bcva_ranges = list(c(5, 10)),     bcva_uplims = list(25, -5),     bcva_lowlims = list(15, -10)   ),   filter = PARAMCD %in% c(\"SBCVA\", \"FBCVA\") ) adbcva <- adbcva %>%   restrict_derivation(     derivation = derive_var_bcvacritxfl,     args = params(       crit_var = exprs(CHG),       bcva_ranges = list(c(5, 10)),       critxfl_index = 10     ),     filter = PARAMCD %in% c(\"SBCVA\", \"FBCVA\")   ) %>%   restrict_derivation(     derivation = derive_var_bcvacritxfl,     args = params(       crit_var = exprs(CHG),       bcva_uplims = list(25, -5),       critxfl_index = 20     ),     filter = PARAMCD %in% c(\"SBCVA\", \"FBCVA\")   ) %>%   restrict_derivation(     derivation = derive_var_bcvacritxfl,     args = params(       crit_var = exprs(CHG),       bcva_lowlims = list(15, -10),       critxfl_index = 30     ),     filter = PARAMCD %in% c(\"SBCVA\", \"FBCVA\")   )"},{"path":"https://pharmaverse.github.io/admiralophtha/articles/adbcva.html","id":"additional-notes","dir":"Articles","previous_headings":"Programming Workflow","what":"Additional Notes","title":"Creating ADBCVA","text":"interpreting endpoints Loss 5 letters fewer relative baseline, implicitly assumed article also includes case letters gained, inequality reads CHG >= -5. One use bcva_lowlims = list(-5) argument derive_var_bcvacritxfl() program endpoint. case, .e. one wishes exclude cases letter gains, inequality interest instead -5 <= CHG <= -1. Importantly, derive_var_bcvacritxfl() still used, argument bcva_ranges = list(c(-5, -1)). vignette extensively showcases use derive_var_bcvacritxfl() applied variable CHG, argument crit_var function can also used create criterion flag relative variables (e.g. crit_var = exprs(AVAL) AVAL).","code":""},{"path":[]},{"path":"https://pharmaverse.github.io/admiralophtha/articles/admiralophtha.html","id":"introduction","dir":"Articles","previous_headings":"","what":"Introduction","title":"Get Started","text":"package extension, new admiral best place first start reading Get Started guide. extension package follows main idea conventions, re-uses many functions admiral, important thoroughly understand able use admiralophtha.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/articles/admiralophtha.html","id":"derivations","dir":"Articles","previous_headings":"","what":"Derivations","title":"Get Started","text":"important functions admiralophtha derivations. follow conventions admiral focused ophthalmology-specific needs.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/articles/admiralophtha.html","id":"starting-a-script","dir":"Articles","previous_headings":"","what":"Starting a Script","title":"Get Started","text":"ophthalmology ADaM data structures, overview flow example function calls common steps provided following vignettes: Creating ADBCVA Creating ADOE Creating ADVFQ","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/articles/admiralophtha.html","id":"support","dir":"Articles","previous_headings":"","what":"Support","title":"Get Started","text":"Support provided via admiral Slack channel.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/articles/adoe.html","id":"introduction","dir":"Articles","previous_headings":"","what":"Introduction","title":"Creating ADOE","text":"article describes creating ADOE ADaM Ophthalmology Exam Analysis data ophthalmology endpoints. used conjunction article creating BDS dataset SDTM. , derivations processes specific ADOE absent, user invited consult aforementioned article guidance. current release admiralophtha contain functionality specific ADOE, article showcases map parameters OE order set basic structure ADOE. following steps, user invited consult -linked article BDS datasets. article updated future releases showcase explain admiralophtha-specific functionality. Note: examples assume CDISC SDTM /ADaM format input unless otherwise specified.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/articles/adoe.html","id":"dataset-contents","dir":"Articles","previous_headings":"Introduction","what":"Dataset Contents","title":"Creating ADOE","text":"admiralophtha suggests populate ADOE general miscellaneous ophthalmology parameters. efficacy endpoint-related parameters (eg. BCVA tests) placed separate datasets (eg. ADBCVA).","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/articles/adoe.html","id":"required-packages","dir":"Articles","previous_headings":"Introduction","what":"Required Packages","title":"Creating ADOE","text":"examples vignette require following packages.","code":"library(dplyr) library(admiral) library(pharmaversesdtm) library(admiraldev) library(admiralophtha)"},{"path":"https://pharmaverse.github.io/admiralophtha/articles/adoe.html","id":"programming-workflow","dir":"Articles","previous_headings":"","what":"Programming Workflow","title":"Creating ADOE","text":"Initial Set ADOE Derivations Standard BDS Variables Example Script","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/articles/adoe.html","id":"setup","dir":"Articles","previous_headings":"Programming Workflow","what":"Initial set up of ADOE","title":"Creating ADOE","text":"BDS ADaM datasets, one start OE SDTM, general ophthalmology records interest. purposes next two sections, shall using admiral OE ADSL test data. also require lookup table mapping parameter codes. Note: simulate ophthalmology study, add randomly generated STUDYEYE variable ADSL, practice STUDYEYE already derived using derive_var_studyeye(). Following setup, programmer can start constructing ADOE. first step subset OE general ophthalmology parameters. , one can merge resulting dataset ADSL. required two reasons: firstly, STUDYEYE crucial mapping AFEYE PARAMCD’s. Secondly, treatment start date (TRTSDT) also prerequisite derivation variables Analysis Day (ADY). next item business derive AVAL, AVALU, DTYPE. example, due small number parameters derivation trivial. AFEYE also created step using function derive_var_afeye(). determine affected eye, function compares OELAT STUDYEYE variable created previous step.","code":"data(\"oe_ophtha\") data(\"admiral_adsl\")  # Add STUDYEYE to ADSL to simulate an ophtha dataset adsl <- admiral_adsl %>%   as.data.frame() %>%   mutate(STUDYEYE = sample(c(\"LEFT\", \"RIGHT\"), n(), replace = TRUE)) %>%   convert_blanks_to_na()  oe <- convert_blanks_to_na(oe_ophtha) %>%   ungroup()  # ---- Lookup table ----  # Assign PARAMCD, PARAM, and PARAMN param_lookup <- tibble::tribble(   ~OETESTCD, ~OECAT, ~OESCAT, ~AFEYE, ~PARAMCD, ~PARAM, ~PARAMN,   \"CSUBTH\", \"OPHTHALMIC ASSESSMENTS\", \"SD-OCT CST SINGLE FORM\", \"Study Eye\", \"SCSUBTH\", \"Study Eye Center Subfield Thickness (um)\", 1, # nolint   \"CSUBTH\", \"OPHTHALMIC ASSESSMENTS\", \"SD-OCT CST SINGLE FORM\", \"Fellow Eye\", \"FCSUBTH\", \"Fellow Eye Center Subfield Thickness (um)\", 2, # nolint   \"DRSSR\", \"OPHTHALMIC ASSESSMENTS\", \"SD-OCT CST SINGLE FORM\", \"Study Eye\", \"SDRSSR\", \"Study Eye Diabetic Retinopathy Severity\", 3, # nolint   \"DRSSR\", \"OPHTHALMIC ASSESSMENTS\", \"SD-OCT CST SINGLE FORM\", \"Fellow Eye\", \"FDRSSR\", \"Fellow Eye Diabetic Retinopathy Severity\", 4, # nolint ) adsl_vars <- exprs(TRTSDT, TRTEDT, TRT01A, TRT01P, STUDYEYE)  adoe <- oe %>%   filter(     OETESTCD %in% c(\"CSUBTH\", \"DRSSR\")   ) %>%   derive_vars_merged(     dataset_add = adsl,     new_vars = adsl_vars,     by_vars = exprs(STUDYID, USUBJID)   ) adoe <- adoe %>%   # Calculate AVAL, AVALC, AVALU and DTYPE   mutate(     AVAL = OESTRESN,     AVALC = OESTRESC,     AVALU = OESTRESU,     DTYPE = NA_character_   ) %>%   # Derive AFEYE needed for PARAMCD derivation   derive_var_afeye(OELOC, OELAT, loc_vals = c(\"EYE\", \"RETINA\"))"},{"path":"https://pharmaverse.github.io/admiralophtha/articles/adoe.html","id":"further","dir":"Articles","previous_headings":"Programming Workflow","what":"Further Derivations of Standard BDS Variables","title":"Creating ADOE","text":"user invited consult article creating BDS dataset SDTM learn add standard BDS variables ADOE.","code":""},{"path":[]},{"path":"https://pharmaverse.github.io/admiralophtha/articles/advfq.html","id":"introduction","dir":"Articles","previous_headings":"","what":"Introduction","title":"Creating ADVFQ","text":"article describes creating ADVFQ ADaM Visual Functioning Questionnaire data ophthalmology endpoints. used conjunction article creating BDS dataset SDTM. , derivations processes specific ADVFQ absent, user invited consult aforementioned article guidance. Note: examples assume CDISC SDTM /ADaM format input unless otherwise specified.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/articles/advfq.html","id":"dataset-contents","dir":"Articles","previous_headings":"Introduction","what":"Dataset Contents","title":"Creating ADVFQ","text":"admiralophtha suggests populate ADVFQ solely VFQ records QS SDTM. questionnaire data placed separate datasets (e.g. ADQS).","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/articles/advfq.html","id":"required-packages","dir":"Articles","previous_headings":"Introduction","what":"Required Packages","title":"Creating ADVFQ","text":"examples vignette require following packages.","code":"library(dplyr) library(admiral) library(pharmaversesdtm) library(admiraldev) library(admiralophtha)"},{"path":"https://pharmaverse.github.io/admiralophtha/articles/advfq.html","id":"programming-workflow","dir":"Articles","previous_headings":"","what":"Programming Workflow","title":"Creating ADVFQ","text":"Initial set ADVFQ Derive Analysis Value existing questions (AVAL) Derive Parameters recoded items summary scores Derive Analysis Variables (ANL01FL ASEQ) Add ADSL Variables Example Script","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/articles/advfq.html","id":"setup","dir":"Articles","previous_headings":"Programming Workflow","what":"Initial set up of ADVFQ","title":"Creating ADVFQ","text":"start, datasets needed creation questionnaire dataset read environment. purpose demonstration shall use admiral QS ADSL test data. QS dataset filtered VFQ parameters interest. Next, programmer create parameter lookup table includes QSTESTCD, PARAMCD, PARAM, PARCAT1 PARCAT2 variables. include parameters needed final ADVFQ used later merge parameter information. Now ADVFQ dataset can constructed, merging filtered QS dataset ADSL. necessary treatment start date TRTSDT prerequisite derivation variables Analysis Day ADY can programmed following article creating BDS dataset SDTM.","code":"data(\"admiral_adsl\") data(\"qs_ophtha\") adsl <- admiral_adsl qs <- qs_ophtha  qs <- qs %>% filter(QSTESTCD %in% c(\"VFQ1\", \"VFQ2\", \"VFQ3\", \"VFQ4\")) param_lookup <- tibble::tribble(   ~QSTESTCD, ~PARAMCD, ~PARAM, ~PARCAT1, ~PARCAT2,   \"VFQ1\", \"VFQ1\", \"Overall Health\", \"NEI VFQ-25\", \"Original Response\",   \"VFQ2\", \"VFQ2\", \"Eyesight in Both Eyes\", \"NEI VFQ-25\", \"Original Response\",   \"VFQ3\", \"VFQ3\", \"Worry About Eyesight\", \"NEI VFQ-25\", \"Original Response\",   \"VFQ4\", \"VFQ4\", \"Pain in and Around Eyes\", \"NEI VFQ-25\", \"Original Response\",   \"QR01\", \"QR01\", \"Recoded Item - 01\", \"NEI VFQ-25\", \"General 01\",   \"QR02\", \"QR02\", \"Recoded Item - 02\", \"NEI VFQ-25\", \"General 01\",   \"QR03\", \"QR03\", \"Recoded Item - 03\", \"NEI VFQ-25\", \"General 02\",   \"QR04\", \"QR04\", \"Recoded Item - 04\", \"NEI VFQ-25\", \"General 02\",   \"QSG01\", \"QSG01\", \"General Score 01\", \"NEI VFQ-25\", \"Averaged Result\",   \"QSG02\", \"QSG02\", \"General Score 02\", \"NEI VFQ-25\", \"Averaged Result\",   \"QBCSCORE\", \"QBCSCORE\", \"Composite Score\", \"NEI VFQ-25\", \"Averaged Result\" ) adsl_vars <- exprs(TRTSDT, TRTEDT, TRT01A, TRT01P)  advfq <- derive_vars_merged(   qs,   dataset_add = adsl,   new_vars = adsl_vars,   by_vars = exprs(STUDYID, USUBJID) )"},{"path":"https://pharmaverse.github.io/admiralophtha/articles/advfq.html","id":"aval","dir":"Articles","previous_headings":"Programming Workflow","what":"Derive Analysis Value for Existing Questions","title":"Creating ADVFQ","text":"derive analysis values use function admiral::derive_vars_merged_lookup() merges PARAMCD parameter lookup table. merges parameter QSTESTCD assigns AVAL AVALC.","code":"advfq <- advfq %>%   ## Add PARAMCD only - add PARAM etc later ----   derive_vars_merged_lookup(     dataset_add = param_lookup,     new_vars = exprs(PARAMCD),     by_vars = exprs(QSTESTCD)   ) %>%   ## Calculate AVAL and AVALC ----   mutate(     AVAL = QSSTRESN,     AVALC = QSORRES   )"},{"path":"https://pharmaverse.github.io/admiralophtha/articles/advfq.html","id":"parameters","dir":"Articles","previous_headings":"Programming Workflow","what":"Derive Parameters for Recoded Items and Summary Scores","title":"Creating ADVFQ","text":"included initial records QS, programmer next program new records parameters recode original questions. Run section code every question need recoding. gives example recoding one question. Next, programmer create summary records average recoded questions using admiral::derive_summary_records. example uses two recoded questions create average record.","code":"## QR01 Recoded Item 01 # set to 100 if [advfq.AVAL] = 1 # else set to 75 if [advfq.AVAL] = 2 # else set to 50 if [advfq.AVAL] = 3 # else set to 25 if [advfq.AVAL] = 4 # else set to 0 if [advfq.AVAL] = 5 advfq <- advfq %>%   derive_summary_records(     by_vars = exprs(STUDYID, USUBJID, !!!adsl_vars, PARAMCD, VISITNUM, VISIT),     filter = QSTESTCD == \"VFQ1\" & !is.na(AVAL),     analysis_var = AVAL,     summary_fun = identity,     set_values_to = exprs(PARAMCD = \"QR01\")   ) %>%   mutate(AVAL = ifelse(PARAMCD == \"QR01\",     case_when(       AVAL == 1 ~ 100,       AVAL == 2 ~ 75,       AVAL == 3 ~ 50,       AVAL == 4 ~ 25,       AVAL >= 5 ~ 0     ),     AVAL   )) ## Derive a new record as a summary record  ---- ## QSG01 General Score 01 # Average of QR01 and QR02 records advfq <- advfq %>%   derive_summary_records(     by_vars = exprs(STUDYID, USUBJID, !!!adsl_vars, VISITNUM, VISIT, ADT, ADY),     filter = PARAMCD %in% c(\"QR01\", \"QR02\") & !is.na(AVAL),     analysis_var = AVAL,     summary_fun = mean,     set_values_to = exprs(PARAMCD = \"QSG01\")   )"},{"path":"https://pharmaverse.github.io/admiralophtha/articles/advfq.html","id":"analysis","dir":"Articles","previous_headings":"Programming Workflow","what":"Derive Analysis Variables","title":"Creating ADVFQ","text":"finding ADaMs, analysis flag derived identify appropriate observation(s) use particular analysis subject multiple observations within particular timing period. situation, analysis flag (e.g. ANLxxFL) may used choose appropriate record analysis. flag may derived using admiral function admiral::derive_var_extreme_flag(). example, assume like choose latest value USUBJID, PARAMCD AVISIT. derive ASEQ using admiral::derive_var_obs_number() based observation number within dataset, additionally merge PARAM, PARCAT1 PARCAT2 using earlier lookup table.","code":"## ANL01FL: Flag last result within an AVISIT for post-baseline records ---- advfq <- advfq %>%   restrict_derivation(     derivation = derive_var_extreme_flag,     args = params(       new_var = ANL01FL,       by_vars = exprs(USUBJID, PARAMCD, AVISIT),       order = exprs(ADT, AVAL),       mode = \"last\"     ),     filter = !is.na(AVISITN) & ONTRTFL == \"Y\"   ) ## Get ASEQ and PARAM  ---- advfq <- advfq %>%   # Calculate ASEQ   derive_var_obs_number(     new_var = ASEQ,     by_vars = exprs(STUDYID, USUBJID),     order = exprs(PARAMCD, ADT, AVISITN, VISITNUM),     check_type = \"error\"   ) %>%   # Derive PARAM   derive_vars_merged(dataset_add = select(param_lookup, -QSTESTCD), by_vars = exprs(PARAMCD))"},{"path":"https://pharmaverse.github.io/admiralophtha/articles/advfq.html","id":"adslvars","dir":"Articles","previous_headings":"Programming Workflow","what":"Add ADSL Variables","title":"Creating ADVFQ","text":"analysis variables programmed, variables ADSL required merged dataset using admiral::derive_vars_merged.","code":"# Add all ADSL variables advfq <- advfq %>%   derive_vars_merged(     dataset_add = select(adsl, !!!negate_vars(adsl_vars)),     by_vars = exprs(STUDYID, USUBJID)   )"},{"path":[]},{"path":"https://pharmaverse.github.io/admiralophtha/articles/standards.html","id":"introduction","dir":"Articles","previous_headings":"","what":"Introduction","title":"Ophthalmology Standards","text":"Ophthalmology hugely diverse therapeutic area, endpoints conventions can differ study study - let alone across companies. Notwithstanding , exist cases alignment possible; page indexes occurrences admiralophtha suggests adoption certain standard way things. Applying standards means mandatory, help leveraging tools (templates, functions, etc.) provided admiralophtha well lower barrier entry programming study. Additionally, page can function guidance programmers starting dip feet ophthalmology ADaM programming.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/articles/standards.html","id":"dataset-subdivision","dir":"Articles","previous_headings":"Introduction","what":"Dataset Subdivision","title":"Ophthalmology Standards","text":"Due aforementioned high complexity diversity ophthalmology data, discouraged funnel records OE SDTM dataset single ADOE dataset, result overly complicated program/dataset pair. admiralophtha instead suggests following partition: ADOE general miscellaneous ophthalmology tests used efficacy programming. ADBCVA BCVA data - almost always constitute primary secondary endpoint require endpoint-related programming criterion flags. endpoints specific efficacy programming may required ADaM dataset (e.g. intraocular pressure data, ADIOP). ADVFQ Visual Functioning Questionnaire data. Subdividing ADaM datasets study ensure wherever custom efficacy programming required, automatically limited data interest. instance, study various endpoints form Gain x y letters relative baseline (similar) likely require criterion variable/flag pair (see Criterion Flag section detail). BCVA data stored ADOE, criterion variable/flag pairs blank irrelevant data dataset, save BCVA records. Conversely, collecting BCVA data ADBCVA ensures criterion variable/flag pairs relevant, resulting dataset readable.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/articles/standards.html","id":"criterion","dir":"Articles","previous_headings":"Introduction","what":"Criterion Flags","title":"Ophthalmology Standards","text":"admiralophtha suggests use criterion variable/flag pairs CRITx/CRITxFL possible endpoint programming. implemented correctly, transparent approach condition CRITxFL can clearly encoded CRITx, without view documentation. appropriate, condition CRITx represented programmatically rather words reduce possibility confusion. instance, endpoint Gain x y letters relative baseline, one set CRIT1 = \"x <= CHG <= y\". Note: Though allowable according ADaM standards, generally discouraged use criterion flag/variable pair one criterion across multiple parameters ADaM dataset, renders dataset confusing scrutinise. BCVA change endpoints, provides function derive_var_bcvacritxfl add en masse. Additionally, function automatically populates CRITx programmatic manner described .","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/articles/standards.html","id":"affected-eye-derivation","dir":"Articles","previous_headings":"Introduction","what":"Affected Eye Derivation","title":"Ophthalmology Standards","text":"admiralophtha function derive_var_afeye follows standard derivation: Set “EYES” Study Eye Selection [ADSL.STUDYEYE] missing, Laterality [xxLAT] equal “BILATERAL”. Else set “STUDY EYE” Study Eye Selection [ADSL.STUDYEYE] either “RIGHT” “LEFT”, matches Laterality [xxLAT] observation record. Else set “STUDY EYE” Study Eye Selection [ADSL.STUDYEYE] “BILATERAL”, Laterality [xxLAT] missing observation record. Else set “FELLOW EYE” Study Eye Selection [ADSL.STUDYEYE] either “RIGHT” “LEFT”, [xxLAT] missing match Laterality [xxLAT] observation record. Else set null. standard values Location [xxLOC] = “EYE” Laterality [xxLAT] = “LEFT”, “RIGHT”, “BILATERAL” study can updated inputs function, otherwise also expected AFEYE derived, warning returned values found.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/authors.html","id":null,"dir":"","previous_headings":"","what":"Authors","title":"Authors and Citation","text":"Edoardo Mancini. Author, maintainer. Ritika Aggarwal. Author. Jane Gao. Author. William Holmes. Author. Josie Jackson. Author. Sonali Jain. Author. Yuki Matsunaga. Author. Gordon Miller. Author. Rachel Linacre. Author. Lucy Palmen. Author. Nandini R Thampi. Author. Aldrich Salva. Author.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/authors.html","id":"citation","dir":"","previous_headings":"","what":"Citation","title":"Authors and Citation","text":"Mancini E, Aggarwal R, Gao J, Holmes W, Jackson J, Jain S, Matsunaga Y, Miller G, Linacre R, Palmen L, R Thampi N, Salva (2023). admiralophtha: ADaM R Asset Library - Ophthalmology. https://pharmaverse.github.io/admiralophtha/, https://github.com/pharmaverse/admiralophtha/.","code":"@Manual{,   title = {admiralophtha: ADaM in R Asset Library - Ophthalmology},   author = {Edoardo Mancini and Ritika Aggarwal and Jane Gao and William Holmes and Josie Jackson and Sonali Jain and Yuki Matsunaga and Gordon Miller and Rachel Linacre and Lucy Palmen and Nandini {R Thampi} and Aldrich Salva},   year = {2023},   note = {https://pharmaverse.github.io/admiralophtha/, https://github.com/pharmaverse/admiralophtha/}, }"},{"path":[]},{"path":"https://pharmaverse.github.io/admiralophtha/index.html","id":"purpose","dir":"","previous_headings":"","what":"Purpose","title":"ADaM in R Asset Library - Ophthalmology","text":"provide complementary (admiral) toolbox enables users develop ophthalmology disease area datasets endpoints.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/index.html","id":"installation","dir":"","previous_headings":"","what":"Installation","title":"ADaM in R Asset Library - Ophthalmology","text":"install latest development version package directly GitHub use following code:","code":"if (!requireNamespace(\"remotes\", quietly = TRUE)) {   install.packages(\"remotes\") } remotes::install_github(\"pharmaverse/admiralophtha\", ref = \"devel\")"},{"path":"https://pharmaverse.github.io/admiralophtha/index.html","id":"scope","dir":"","previous_headings":"","what":"Scope","title":"ADaM in R Asset Library - Ophthalmology","text":"Build toolbox re-usable functions utilities create Ophthalmology-specific ADaM datasets R modular manner. functions created based upon ADaM Implementation Guide aim facilitate programming ADaM dataset standards.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/index.html","id":"references-and-documentation","dir":"","previous_headings":"","what":"References and Documentation","title":"ADaM in R Asset Library - Ophthalmology","text":"Please refer {admiral} References Documentation.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/index.html","id":"r-versions","dir":"","previous_headings":"","what":"R Versions","title":"ADaM in R Asset Library - Ophthalmology","text":"’s summary strategy package related R versions: R versions developers users follow admiral core package. development devel branch admiral core used dependency. releasing new admiralophtha version must run using latest released admiral core version, .e., main branch admiral core.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/index.html","id":"contact","dir":"","previous_headings":"","what":"Contact","title":"ADaM in R Asset Library - Ophthalmology","text":"use following support communications user developer community: Slack - informal discussions, Q&building user community. don’t access, use link join pharmaverse Slack workspace GitHub Issues - direct feedback, enhancement requests raising bugs","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/index.html","id":"release-schedule","dir":"","previous_headings":"","what":"Release Schedule","title":"ADaM in R Asset Library - Ophthalmology","text":"first release (v. 0.1.0) came 13th March 2023. second release (v. 0.2.0) came 12th June 2023. third release (v. 0.3.0) came 18th September 2023. planning fourth release end 2023.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/admiralophtha-package.html","id":null,"dir":"Reference","previous_headings":"","what":"admiralophtha: ADaM in R Asset Library - Ophthalmology — admiralophtha-package","title":"admiralophtha: ADaM in R Asset Library - Ophthalmology — admiralophtha-package","text":"Aids programming Clinical Data Standards Interchange Consortium (CDISC) compliant Ophthalmology Analysis Data Model (ADaM) datasets R. ADaM datasets mandatory part New Drug Biologics License Application submitted United States Food Drug Administration (FDA). Analysis derivations implemented accordance \"Analysis Data Model Implementation Guide\" (CDISC Analysis Data Model Team, 2021, https://www.cdisc.org/standards/foundational/adam/adamig-v1-3-release-package).","code":""},{"path":[]},{"path":"https://pharmaverse.github.io/admiralophtha/reference/admiralophtha-package.html","id":"author","dir":"Reference","previous_headings":"","what":"Author","title":"admiralophtha: ADaM in R Asset Library - Ophthalmology — admiralophtha-package","text":"Maintainer: Edoardo Mancini edoardo.mancini@roche.com Authors: Ritika Aggarwal ritika.aggarwal@novartis.com Jane Gao jane.gao@roche.com William Holmes william.holmes@roche.com Josie Jackson josie.jackson@roche.com Sonali Jain sonali.jain@novartis.com Yuki Matsunaga yuki.matsunaga@novartis.com Gordon Miller gordon.miller@roche.com Rachel Linacre rachel.linacre@roche.com Lucy Palmen lucy.palmen@roche.com Nandini R Thampi nandini.rajendhiran@novartis.com Aldrich Salva salva.aldrich@gene.com","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/admiralophtha_adbcva.html","id":null,"dir":"Reference","previous_headings":"","what":"Best Corrected Visual Acuity Analysis Dataset — admiralophtha_adbcva","title":"Best Corrected Visual Acuity Analysis Dataset — admiralophtha_adbcva","text":"example Best Corrected Visual Acuity (BCVA) analysis dataset","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/admiralophtha_adbcva.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Best Corrected Visual Acuity Analysis Dataset — admiralophtha_adbcva","text":"","code":"admiralophtha_adbcva"},{"path":"https://pharmaverse.github.io/admiralophtha/reference/admiralophtha_adbcva.html","id":"format","dir":"Reference","previous_headings":"","what":"Format","title":"Best Corrected Visual Acuity Analysis Dataset — admiralophtha_adbcva","text":"object class tbl_df (inherits tbl, data.frame) 7672 rows 116 columns.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/admiralophtha_adbcva.html","id":"source","dir":"Reference","previous_headings":"","what":"Source","title":"Best Corrected Visual Acuity Analysis Dataset — admiralophtha_adbcva","text":"Derived OE ADSL datasets using {admiral}, {admiralophtha} (https://github.com/pharmaverse/admiralophtha/blob/main/inst/templates/ad_adbcva.R)","code":""},{"path":[]},{"path":"https://pharmaverse.github.io/admiralophtha/reference/admiralophtha_adoe.html","id":null,"dir":"Reference","previous_headings":"","what":"Ophthalmology Exam Analysis Dataset — admiralophtha_adoe","title":"Ophthalmology Exam Analysis Dataset — admiralophtha_adoe","text":"example Ophthalmology Exam Analysis dataset","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/admiralophtha_adoe.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Ophthalmology Exam Analysis Dataset — admiralophtha_adoe","text":"","code":"admiralophtha_adoe"},{"path":"https://pharmaverse.github.io/admiralophtha/reference/admiralophtha_adoe.html","id":"format","dir":"Reference","previous_headings":"","what":"Format","title":"Ophthalmology Exam Analysis Dataset — admiralophtha_adoe","text":"object class tbl_df (inherits tbl, data.frame) 7672 rows 98 columns.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/admiralophtha_adoe.html","id":"source","dir":"Reference","previous_headings":"","what":"Source","title":"Ophthalmology Exam Analysis Dataset — admiralophtha_adoe","text":"Derived OE ADSL datasets using {admiral}, {admiralophtha} (https://github.com/pharmaverse/admiralophtha/blob/main/inst/templates/ad_adoe.R)","code":""},{"path":[]},{"path":"https://pharmaverse.github.io/admiralophtha/reference/admiralophtha_advfq.html","id":null,"dir":"Reference","previous_headings":"","what":"Visual Function Questionnaire Analysis Dataset — admiralophtha_advfq","title":"Visual Function Questionnaire Analysis Dataset — admiralophtha_advfq","text":"example Visual Function Questionnaire (VFQ) analysis dataset","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/admiralophtha_advfq.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Visual Function Questionnaire Analysis Dataset — admiralophtha_advfq","text":"","code":"admiralophtha_advfq"},{"path":"https://pharmaverse.github.io/admiralophtha/reference/admiralophtha_advfq.html","id":"format","dir":"Reference","previous_headings":"","what":"Format","title":"Visual Function Questionnaire Analysis Dataset — admiralophtha_advfq","text":"object class tbl_df (inherits tbl, data.frame) 28798 rows 41 columns.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/admiralophtha_advfq.html","id":"source","dir":"Reference","previous_headings":"","what":"Source","title":"Visual Function Questionnaire Analysis Dataset — admiralophtha_advfq","text":"Derived ADSL QS datasets using {admiral}, {admiralophtha} (https://github.com/pharmaverse/admiralophtha/blob/main/inst/templates/ad_advfq.R)","code":""},{"path":[]},{"path":"https://pharmaverse.github.io/admiralophtha/reference/convert_etdrs_to_logmar.html","id":null,"dir":"Reference","previous_headings":"","what":"ETDRS --> LogMAR conversion — convert_etdrs_to_logmar","title":"ETDRS --> LogMAR conversion — convert_etdrs_to_logmar","text":"Convert ETDRS score LogMAR units","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/convert_etdrs_to_logmar.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"ETDRS --> LogMAR conversion — convert_etdrs_to_logmar","text":"","code":"convert_etdrs_to_logmar(value)"},{"path":"https://pharmaverse.github.io/admiralophtha/reference/convert_etdrs_to_logmar.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"ETDRS --> LogMAR conversion — convert_etdrs_to_logmar","text":"value object containing ETDRS score convert logMAR","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/convert_etdrs_to_logmar.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"ETDRS --> LogMAR conversion — convert_etdrs_to_logmar","text":"input value converted converted logMAR units","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/convert_etdrs_to_logmar.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"ETDRS --> LogMAR conversion — convert_etdrs_to_logmar","text":"ETDRS value converted logMAR logMAR = -0.02 * ETDRS + 1.7 Source conversion formula: Beck, R.W., et al. computerized method visual acuity testing. American Journal Ophthalmology, 135(2), pp.194–205. doi:https://doi.org/10.1016/s0002-9394(02)01825-1.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/convert_etdrs_to_logmar.html","id":"author","dir":"Reference","previous_headings":"","what":"Author","title":"ETDRS --> LogMAR conversion — convert_etdrs_to_logmar","text":"Rachel Linacre","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/convert_etdrs_to_logmar.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"ETDRS --> LogMAR conversion — convert_etdrs_to_logmar","text":"","code":"library(tibble) library(dplyr) #>  #> Attaching package: ‘dplyr’ #> The following objects are masked from ‘package:stats’: #>  #>     filter, lag #> The following objects are masked from ‘package:base’: #>  #>     intersect, setdiff, setequal, union library(admiral) library(admiraldev) #>  #> Attaching package: ‘admiraldev’ #> The following objects are masked from ‘package:dplyr’: #>  #>     anti_join, filter_if, inner_join, left_join  adbcva <- tribble(   ~STUDYID, ~USUBJID, ~AVAL,   \"XXX001\", \"P01\", 5,   \"XXX001\", \"P02\", 10,   \"XXX001\", \"P03\", 15,   \"XXX001\", \"P04\", 20,   \"XXX001\", \"P05\", 25 )  adbcva <- adbcva %>% mutate(AVAL = convert_etdrs_to_logmar(AVAL))"},{"path":"https://pharmaverse.github.io/admiralophtha/reference/convert_logmar_to_etdrs.html","id":null,"dir":"Reference","previous_headings":"","what":"LogMAR --> ETDRS conversion — convert_logmar_to_etdrs","title":"LogMAR --> ETDRS conversion — convert_logmar_to_etdrs","text":"Convert LogMAR score ETDRS units","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/convert_logmar_to_etdrs.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"LogMAR --> ETDRS conversion — convert_logmar_to_etdrs","text":"","code":"convert_logmar_to_etdrs(value)"},{"path":"https://pharmaverse.github.io/admiralophtha/reference/convert_logmar_to_etdrs.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"LogMAR --> ETDRS conversion — convert_logmar_to_etdrs","text":"value object containing logMAR score convert ETDRS","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/convert_logmar_to_etdrs.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"LogMAR --> ETDRS conversion — convert_logmar_to_etdrs","text":"input value converted ETDRS units","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/convert_logmar_to_etdrs.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"LogMAR --> ETDRS conversion — convert_logmar_to_etdrs","text":"logMAR value converted ETDRS ETDRS = -(logMAR - 1.7) / 0.02 Source conversion formula: Beck, R.W., et al. computerized method visual acuity testing. American Journal Ophthalmology, 135(2), pp.194–205. doi:https://doi.org/10.1016/s0002-9394(02)01825-1.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/convert_logmar_to_etdrs.html","id":"author","dir":"Reference","previous_headings":"","what":"Author","title":"LogMAR --> ETDRS conversion — convert_logmar_to_etdrs","text":"Nandini R Thampi","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/convert_logmar_to_etdrs.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"LogMAR --> ETDRS conversion — convert_logmar_to_etdrs","text":"","code":"library(tibble) library(dplyr) library(admiral)  oe <- tribble(   ~STUDYID, ~USUBJID, ~OETESTCD, ~OEMETHOD, ~OESTRESN,   \"XXX001\", \"P01\", \"VACSCORE\", \"logMAR EYE CHART\", 1.08,   \"XXX001\", \"P02\", \"VACSCORE\", \"logMAR EYE CHART\", 1.66,   \"XXX001\", \"P03\", \"VACSCORE\", \"logMAR EYE CHART\", 1.60,   \"XXX001\", \"P04\", \"VACSCORE\", \"ETDRS EYE CHART\", 57,   \"XXX001\", \"P05\", \"VACSCORE\", \"ETDRS EYE CHART\", 1 )  adbcva <- oe %>%   filter(OETESTCD == \"VACSCORE\" & toupper(OEMETHOD) == \"LOGMAR EYE CHART\") %>%   mutate(OESTRESN = convert_logmar_to_etdrs(OESTRESN))"},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_afeye.html","id":null,"dir":"Reference","previous_headings":"","what":"Derive Affected Eye — derive_var_afeye","title":"Derive Affected Eye — derive_var_afeye","text":"Derive Affected Eye (AFEYE) occurrence datasets","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_afeye.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Derive Affected Eye — derive_var_afeye","text":"","code":"derive_var_afeye(   dataset_occ,   loc_var,   lat_var,   loc_vals = \"EYE\",   lat_vals = c(\"LEFT\", \"RIGHT\", \"BILATERAL\") )"},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_afeye.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Derive Affected Eye — derive_var_afeye","text":"dataset_occ Input Occurence dataset loc_var Location variable lat_var Laterality variable loc_vals xxLOCvalues AFEYE derived lat_vals xxLATvalues AFEYE derived","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_afeye.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Derive Affected Eye — derive_var_afeye","text":"input occurrence dataset Affected Eye (AFEYE) added.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_afeye.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Derive Affected Eye — derive_var_afeye","text":"Affected Eye derived occurrence dataset using laterality Study Eye. assumes Study Eye already added ADSL.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_afeye.html","id":"author","dir":"Reference","previous_headings":"","what":"Author","title":"Derive Affected Eye — derive_var_afeye","text":"Lucy Palmen","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_afeye.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Derive Affected Eye — derive_var_afeye","text":"","code":"library(tibble) library(admiral)  adae <- tribble(   ~STUDYID, ~USUBJID, ~STUDYEYE, ~AELOC, ~AELAT,   \"XXX001\", \"P01\", \"RIGHT\", \"EYE\", \"RIGHT\",   \"XXX001\", \"P01\", \"RIGHT\", \"EYE\", \"LEFT\",   \"XXX001\", \"P01\", \"RIGHT\", \"EYE\", \"\",   \"XXX001\", \"P01\", \"RIGHT\", \"\", \"RIGHT\",   \"XXX001\", \"P02\", \"LEFT\", \"\", \"\",   \"XXX001\", \"P02\", \"LEFT\", \"EYE\", \"LEFT\",   \"XXX001\", \"P04\", \"BILATERAL\", \"EYE\", \"RIGHT\",   \"XXX001\", \"P05\", \"RIGHT\", \"EYE\", \"RIGHT\",   \"XXX001\", \"P05\", \"RIGHT\", \"EYE\", \"BILATERAL\",   \"XXX001\", \"P06\", \"BILATERAL\", \"\", \"\",   \"XXX001\", \"P06\", \"BILATERAL\", \"\", \"RIGHT\",   \"XXX001\", \"P07\", \"BILATERAL\", \"EYE\", \"BILATERAL\",   \"XXX001\", \"P08\", \"\", \"EYE\", \"BILATERAL\",   \"XXX001\", \"P09\", \"NONSENSE\", \"EYE\", \"BILATERAL\",   \"XXX001\", \"P09\", \"BILATERAL\", \"EYE\", \"NONSENSE\",   \"XXX001\", \"P09\", \"BILATERAL\", \"NONSENSE\", \"BILATERAL\",   \"XXX001\", \"P10\", \"RIGHT\", \"EYE\", \"BOTH\" )  adae <- derive_var_afeye(adae, AELOC, AELAT) #> Warning: Warning: value not in lat_vals #> Warning: Warning: value not in loc_vals #> Warning: Warning: STUDYEYE is expected to be 'LEFT', 'RIGHT' or 'BILATERAL'"},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_bcvacritxfl.html","id":null,"dir":"Reference","previous_headings":"","what":"Adds CRITx/CRITxFL pairs to BCVA dataset — derive_var_bcvacritxfl","title":"Adds CRITx/CRITxFL pairs to BCVA dataset — derive_var_bcvacritxfl","text":"Adds criterion variables CRITx corresponding flags CRITxFL dataset containing BCVA records","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_bcvacritxfl.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Adds CRITx/CRITxFL pairs to BCVA dataset — derive_var_bcvacritxfl","text":"","code":"derive_var_bcvacritxfl(   dataset,   crit_var,   bcva_ranges = NULL,   bcva_uplims = NULL,   bcva_lowlims = NULL,   additional_text = \"\",   critxfl_index = NULL )"},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_bcvacritxfl.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Adds CRITx/CRITxFL pairs to BCVA dataset — derive_var_bcvacritxfl","text":"dataset Input dataset containing BCVA data (usually ADBCVA). crit_var Variable respect CRITx/CRITxFL derived (usually CHG AVAL). bcva_ranges List containing one numeric vectors length 2. vector c(,b) bcva_ranges, pair variables CRITx, CRITxFL created condition: <=  crit_var <= b. criterion flags type required, leave NULL. bcva_uplims List containing one numeric elements. element bcva_uplims, pair variables CRITx, CRITxFL created condition: crit_var <= . criterion flags type required, leave NULL. bcva_lowlims List containing one numeric elements. element b bcva_lowlims, pair variables CRITx, CRITxFL created condition: crit_var >= b. criterion flags type required, leave NULL. additional_text string containing additional text append CRITx critxfl_index positive integer detailing first value x use CRITxFL. supplied, function takes first available value x, counting x = 1.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_bcvacritxfl.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Adds CRITx/CRITxFL pairs to BCVA dataset — derive_var_bcvacritxfl","text":"input BCVA dataset additional column pairsCRITx, CRITxFL.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_bcvacritxfl.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Adds CRITx/CRITxFL pairs to BCVA dataset — derive_var_bcvacritxfl","text":"function works calling derive_var_bcvacritxfl() elements bcva_ranges, bcva_uplims bcva_lowlims. NOTE: crit_var equal NA, resulting criterion flag also marked NA.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_bcvacritxfl.html","id":"author","dir":"Reference","previous_headings":"","what":"Author","title":"Adds CRITx/CRITxFL pairs to BCVA dataset — derive_var_bcvacritxfl","text":"Edoardo Mancini","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_bcvacritxfl.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Adds CRITx/CRITxFL pairs to BCVA dataset — derive_var_bcvacritxfl","text":"","code":"library(tibble) library(admiral) library(admiraldev)  adbcva1 <- tribble(   ~STUDYID, ~USUBJID, ~AVISIT, ~BASETYPE, ~PARAMCD, ~CHG,   \"XXX001\", \"P01\", \"BASELINE\", \"LAST\", \"SBCVA\", 0,   \"XXX001\", \"P01\", \"WEEK 2\", \"LAST\", \"FBCVA\", 2,   \"XXX001\", \"P02\", \"BASELINE\", \"LAST\", \"SBCVA\", -13,   \"XXX001\", \"P02\", \"WEEK 2\", \"LAST\", \"FBCVA\", 5,   \"XXX001\", \"P03\", \"BASELINE\", \"LAST\", \"SBCVA\", NA,   \"XXX001\", \"P03\", \"WEEK 2\", \"LAST\", \"FBCVA\", 17 )  derive_var_bcvacritxfl(   dataset = adbcva1,   crit_var = exprs(CHG),   bcva_ranges = list(c(0, 5), c(-5, -1), c(10, 15)),   bcva_uplims = list(5, 10),   bcva_lowlims = list(8),   additional_text = \"\" ) #> # A tibble: 6 × 18 #>   STUDYID USUBJID AVISIT   BASETYPE PARAMCD   CHG CRIT1    CRIT1FL CRIT2 CRIT2FL #>   <chr>   <chr>   <chr>    <chr>    <chr>   <dbl> <chr>    <chr>   <chr> <chr>   #> 1 XXX001  P01     BASELINE LAST     SBCVA       0 0 <= CH… Y       -5 <… N       #> 2 XXX001  P01     WEEK 2   LAST     FBCVA       2 0 <= CH… Y       -5 <… N       #> 3 XXX001  P02     BASELINE LAST     SBCVA     -13 0 <= CH… N       -5 <… N       #> 4 XXX001  P02     WEEK 2   LAST     FBCVA       5 0 <= CH… Y       -5 <… N       #> 5 XXX001  P03     BASELINE LAST     SBCVA      NA 0 <= CH… NA      -5 <… NA      #> 6 XXX001  P03     WEEK 2   LAST     FBCVA      17 0 <= CH… N       -5 <… N       #> # ℹ 8 more variables: CRIT3 <chr>, CRIT3FL <chr>, CRIT4 <chr>, CRIT4FL <chr>, #> #   CRIT5 <chr>, CRIT5FL <chr>, CRIT6 <chr>, CRIT6FL <chr>  adbcva2 <- tribble(   ~STUDYID, ~USUBJID, ~AVISIT, ~BASETYPE, ~PARAMCD, ~AVAL, ~CHG,   \"XXX001\", \"P01\", \"BASELINE\", \"LAST\", \"SBCVA\", 4, NA,   \"XXX001\", \"P01\", \"BASELINE\", \"LAST\", \"SBCVA\", 6, NA,   \"XXX001\", \"P01\", \"AVERAGE BASELINE\", \"AVERAGE\", \"SBCVA\", 5, NA,   \"XXX001\", \"P01\", \"WEEK 2\", \"LAST\", \"SBCVA\", -3, NA,   \"XXX001\", \"P01\", \"WEEK 4\", \"LAST\", \"SBCVA\", -10, NA,   \"XXX001\", \"P01\", \"WEEK 6\", \"LAST\", \"SBCVA\", 12, NA,   \"XXX001\", \"P01\", \"WEEK 2\", \"AVERAGE\", \"SBCVA\", -2, -7,   \"XXX001\", \"P01\", \"WEEK 4\", \"AVERAGE\", \"SBCVA\", 6, 1,   \"XXX001\", \"P01\", \"WEEK 6\", \"AVERAGE\", \"SBCVA\", 3, -2 )  restrict_derivation(   adbcva2,   derivation = derive_var_bcvacritxfl,   args = params(     crit_var = exprs(CHG),     bcva_ranges = list(c(0, 5), c(-10, 0)),     bcva_lowlims = list(5),     additional_text = \" (AVERAGE)\"   ),   filter = PARAMCD %in% c(\"SBCVA\", \"FBCVA\") & BASETYPE == \"AVERAGE\" ) #> # A tibble: 9 × 13 #>   STUDYID USUBJID AVISIT        BASETYPE PARAMCD  AVAL   CHG CRIT1 CRIT1FL CRIT2 #>   <chr>   <chr>   <chr>         <chr>    <chr>   <dbl> <dbl> <chr> <chr>   <chr> #> 1 XXX001  P01     AVERAGE BASE… AVERAGE  SBCVA       5    NA 0 <=… NA      -10 … #> 2 XXX001  P01     WEEK 2        AVERAGE  SBCVA      -2    -7 0 <=… N       -10 … #> 3 XXX001  P01     WEEK 4        AVERAGE  SBCVA       6     1 0 <=… Y       -10 … #> 4 XXX001  P01     WEEK 6        AVERAGE  SBCVA       3    -2 0 <=… N       -10 … #> 5 XXX001  P01     BASELINE      LAST     SBCVA       4    NA NA    NA      NA    #> 6 XXX001  P01     BASELINE      LAST     SBCVA       6    NA NA    NA      NA    #> 7 XXX001  P01     WEEK 2        LAST     SBCVA      -3    NA NA    NA      NA    #> 8 XXX001  P01     WEEK 4        LAST     SBCVA     -10    NA NA    NA      NA    #> 9 XXX001  P01     WEEK 6        LAST     SBCVA      12    NA NA    NA      NA    #> # ℹ 3 more variables: CRIT2FL <chr>, CRIT3 <chr>, CRIT3FL <chr>"},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_bcvacritxfl_util.html","id":null,"dir":"Reference","previous_headings":"","what":"Add CRITx/CRITxFL pair to BCVA dataset — derive_var_bcvacritxfl_util","title":"Add CRITx/CRITxFL pair to BCVA dataset — derive_var_bcvacritxfl_util","text":"Helper function derive_var_bcvacritxfl() adds criterion variable CRITx corresponding flag CRITxFL dataset containing BCVA records","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_bcvacritxfl_util.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Add CRITx/CRITxFL pair to BCVA dataset — derive_var_bcvacritxfl_util","text":"","code":"derive_var_bcvacritxfl_util(   dataset,   crit_var,   critx_text,   critxfl_cond,   counter,   bcva_range = NULL,   bcva_uplim = NULL,   bcva_lowlim = NULL )"},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_bcvacritxfl_util.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Add CRITx/CRITxFL pair to BCVA dataset — derive_var_bcvacritxfl_util","text":"dataset Input dataset (usually ADBCVA). crit_var Variable respect CRITx/CRITxFL derived (usually CHG AVAL). critx_text String containing text CRITx variable. critxfl_cond String containing R code detailing criterion satisfied CRITxFL variable equal \"Y\". counter Integer detailing value x use CRITxFL. bcva_range Numeric vector length two detailing lower upper change BCVA limits (bcva_range called critxfl_cond criterion stipulates change BCVA lie inside range). bcva_uplim Numeric value detailing highest change BCVA limit (bcva_uplim called critxfl_cond criterion stipulates change BCVA lie upper limit). bcva_lowlim Numeric value detailing lowest change BCVA limit (bcva_lowlim called critxfl_cond criterion stipulates change BCVA lie lower limit).","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_bcvacritxfl_util.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Add CRITx/CRITxFL pair to BCVA dataset — derive_var_bcvacritxfl_util","text":"input BCVA dataset additional columns CRITx, CRITxFL.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_bcvacritxfl_util.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Add CRITx/CRITxFL pair to BCVA dataset — derive_var_bcvacritxfl_util","text":"criterion change BCVA CRITxFL can three types: (1) value lies within range; <= crit_var <= b; (2) value upper limit; crit_var <= ; (3) value lower limit; b <= crit_var. (1), bcva_range must specified function; (2), bcva_uplim; (3) bcva_lowlim. necessary supply least one three arguments. NOTE: crit_var equal NA, resulting criterion flag also marked NA.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_bcvacritxfl_util.html","id":"author","dir":"Reference","previous_headings":"","what":"Author","title":"Add CRITx/CRITxFL pair to BCVA dataset — derive_var_bcvacritxfl_util","text":"Edoardo Mancini","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_studyeye.html","id":null,"dir":"Reference","previous_headings":"","what":"Derive Study Eye — derive_var_studyeye","title":"Derive Study Eye — derive_var_studyeye","text":"Derive Study Eye (STUDYEYE) ADSL dataset","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_studyeye.html","id":"ref-usage","dir":"Reference","previous_headings":"","what":"Usage","title":"Derive Study Eye — derive_var_studyeye","text":"","code":"derive_var_studyeye(dataset_adsl, dataset_sc, sctestcd_value = \"FOCID\")"},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_studyeye.html","id":"arguments","dir":"Reference","previous_headings":"","what":"Arguments","title":"Derive Study Eye — derive_var_studyeye","text":"dataset_adsl ADSL input dataset dataset_sc SC input dataset sctestcd_value SCTESTCD value flagging Study Eye selection records. Default: \"FOCID\".","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_studyeye.html","id":"value","dir":"Reference","previous_headings":"","what":"Value","title":"Derive Study Eye — derive_var_studyeye","text":"input ADSL dataset additional column named STUDYEYE","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_studyeye.html","id":"details","dir":"Reference","previous_headings":"","what":"Details","title":"Derive Study Eye — derive_var_studyeye","text":"Study Eye derived ADSL using \"Study Eye selection\" records SC SDTM dataset.","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_studyeye.html","id":"author","dir":"Reference","previous_headings":"","what":"Author","title":"Derive Study Eye — derive_var_studyeye","text":"Edoardo Mancini","code":""},{"path":"https://pharmaverse.github.io/admiralophtha/reference/derive_var_studyeye.html","id":"ref-examples","dir":"Reference","previous_headings":"","what":"Examples","title":"Derive Study Eye — derive_var_studyeye","text":"","code":"library(tibble) library(admiral)  adsl <- tribble(   ~STUDYID, ~USUBJID,   \"XXX001\", \"P01\",   \"XXX001\", \"P02\",   \"XXX001\", \"P03\",   \"XXX001\", \"P04\",   \"XXX001\", \"P05\" )  sc <- tribble(   ~STUDYID, ~USUBJID, ~SCTESTCD, ~SCSTRESC,   \"XXX001\", \"P01\", \"FOCID\", \"OS\",   \"XXX001\", \"P01\", \"ACOHORT\", \"COHORT1\",   \"XXX001\", \"P02\", \"FOCID\", \"OD\",   \"XXX001\", \"P02\", \"ACOHORT\", \"COHORT3\",   \"XXX001\", \"P04\", \"FOCID\", \"OU\",   \"XXX001\", \"P05\", \"FOCID\", \"OD\",   \"XXX001\", \"P06\", \"FOCID\", \"OS\" )  derive_var_studyeye(adsl, sc) #> # A tibble: 5 × 3 #>   STUDYID USUBJID STUDYEYE    #>   <chr>   <chr>   <chr>       #> 1 XXX001  P01     \"LEFT\"      #> 2 XXX001  P02     \"RIGHT\"     #> 3 XXX001  P03     \"\"          #> 4 XXX001  P04     \"BILATERAL\" #> 5 XXX001  P05     \"RIGHT\""}]
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