From a51b5e9133a3a10b5028c28fc42722ac3599fed2 Mon Sep 17 00:00:00 2001 From: Nicholas Eugenio Date: Wed, 9 Aug 2023 21:19:31 +0000 Subject: [PATCH 01/15] First ideas --- R/create_blogpost.R | 10 ++--- posts/2023-08-30_pharmaverse_story/appendix.R | 0 .../pharmaverse.png | Bin 0 -> 21533 bytes .../pharmaverse_story.qmd | 38 ++++++++++++++++++ 4 files changed, 43 insertions(+), 5 deletions(-) create mode 100644 posts/2023-08-30_pharmaverse_story/appendix.R create mode 100644 posts/2023-08-30_pharmaverse_story/pharmaverse.png create mode 100644 posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd diff --git a/R/create_blogpost.R b/R/create_blogpost.R index 180efbcf..8cd52905 100644 --- a/R/create_blogpost.R +++ b/R/create_blogpost.R @@ -15,12 +15,12 @@ c( # Fill in the info, e.g.: create_post( - post_name = "falcon", # needs to be character vector (length 1) - post_date = "2023-07-09", # needs to be character vector (length 1) + post_name = "pharmaverse story", # needs to be character vector (length 1) + post_date = "2023-08-30", # needs to be character vector (length 1) description = "", # you can fill the description in later as well - author = c("Vincent Shen"), # one or more authors are permitted - cover_image = "falcon", # chose one of the above (see line 8) - tags = c("falcon", "displays") # chose (multiple) from line 10 + author = c("Nicholas Eugenio"), # one or more authors are permitted + cover_image = "pharmaverse", # chose one of the above (see line 8) + tags = c("community") # chose (multiple) from line 10 ) diff --git a/posts/2023-08-30_pharmaverse_story/appendix.R b/posts/2023-08-30_pharmaverse_story/appendix.R new file mode 100644 index 00000000..e69de29b diff --git a/posts/2023-08-30_pharmaverse_story/pharmaverse.png b/posts/2023-08-30_pharmaverse_story/pharmaverse.png new file mode 100644 index 0000000000000000000000000000000000000000..0d7fc797c590be7d0c604d20dde5c0dcda36e1ae GIT binary patch literal 21533 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z;b-e2oC910GT7bs+>E|9iS4a+fp7I3XlR4%JA2gazp1aaF*@b^nug@HE-N<5`6nf-}=+oN=#wj9qxc=Jv*DaHpw!3qU>i@GU5d%oVe@-Pw`A8k!!ZKLnf9@58 zC$~ox?ED--Y+OT}b=A7m?k#OLLkXM^|L`Z`4`4u$CHx&YdR)Z&fgmP(p%+JK1Sqnw veb`vt_ELiCK4l + +```{r setup, include=FALSE} +long_slug <- "2023-08-30_pharmaverse_story" +# renv::use(lockfile = "renv.lock") +``` + + + +**Story** + +Since the earliest peoples recorded to have inhabited the Earth, like the Australian Aboriginal peoples (who have been in Australia for at least 65,000 to 80,000 years, according to [Encyclopædia Britannica](https://www.britannica.com/topic/Australian-Aboriginal)), human beings live in group. +Whether to protect yourself, increase your life expectancy or simply share tasks. + +John Donne used to say *"No man is an island entire of itself; every man is a piece of the continent, a part of the main;"*. + + + +```{r, echo=FALSE} +source("appendix.R") +insert_appendix( + repo_spec = "pharmaverse/blog", + name = long_slug +) +``` From bf9281861a000ae5b9a6c19d1fac3cf9ce15a389 Mon Sep 17 00:00:00 2001 From: Nicholas Eugenio Date: Mon, 14 Aug 2023 21:14:30 +0000 Subject: [PATCH 02/15] Introducing the context --- .../pharmaverse_story.qmd | 20 +++++++++++++++++-- 1 file changed, 18 insertions(+), 2 deletions(-) diff --git a/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd b/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd index cabebc86..1a391cc0 100644 --- a/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd +++ b/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd @@ -22,10 +22,26 @@ long_slug <- "2023-08-30_pharmaverse_story" **Story** -Since the earliest peoples recorded to have inhabited the Earth, like the Australian Aboriginal peoples (who have been in Australia for at least 65,000 to 80,000 years, according to [Encyclopædia Britannica](https://www.britannica.com/topic/Australian-Aboriginal)), human beings live in group. +Since the Australian Aboriginal, the earliest peoples recorded to have inhabited the Earth and who have been in Australia for at least 65,000 to 80,000 years ([Encyclopædia Britannica](https://www.britannica.com/topic/Australian-Aboriginal)), human beings live in group. Whether to protect yourself, increase your life expectancy or simply share tasks. -John Donne used to say *"No man is an island entire of itself; every man is a piece of the continent, a part of the main;"*. +For most aspects of life, it doesn't make sense to think, act or work alone for two main reasons: + +1. You will spend more energy and time; + +2. Someone else may be facing (or have faced) the same situation. + +The English poet John Donne used to say *"No man is an island entire of itself; every man is a piece of the continent, a part of the main;"*. +I can't disagree with him. +And I dare say that Michael Rimler (GSK), Mike Stackhouse (Atorus), Ross Farrugia (Roche), and Sumesh Kalappurakal (Janssen) agree with me. +They are the founders of [pharmaverse](https://pharmaverse.org/), members of its Council and kindly shared their memories of how independent companies, in mid-2020, worked together in the creation of a set of packages developed to support the clinical reporting pipeline. + +If you are not familiar with this pipeline, you just need to know that, in a nutshell, pharmaceutical companies must follow a bunch of standardized procedures and formats when submitting clinical results to Health Authorities. +Remember that: **different** companies seeking the **same** standards of outputs. + +And paraphrasing Ross presentation in [R/PHARMA 2022](https://www.youtube.com/watch?v=APMDOS4v9Hk), I'd like also to point out that, thinking of the development of a new drug, we are talking about a "post-competitive" scenario, where the drug was already discovered and we "only" must produce and deliver results. + +More precisely, From 4f7cba7f776d0fa5720db6385f23329e2910c95f Mon Sep 17 00:00:00 2001 From: Nicholas Eugenio Date: Thu, 17 Aug 2023 14:26:19 +0000 Subject: [PATCH 03/15] Updates with references --- .../pharmaverse_story.qmd | 36 ++++++++++++++++--- 1 file changed, 31 insertions(+), 5 deletions(-) diff --git a/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd b/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd index 1a391cc0..4fb848ec 100644 --- a/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd +++ b/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd @@ -1,5 +1,5 @@ --- -title: "pharmaverse story" +title: "pharmaverse (hi)story" author: - name: Nicholas Eugenio description: "" @@ -36,12 +36,38 @@ I can't disagree with him. And I dare say that Michael Rimler (GSK), Mike Stackhouse (Atorus), Ross Farrugia (Roche), and Sumesh Kalappurakal (Janssen) agree with me. They are the founders of [pharmaverse](https://pharmaverse.org/), members of its Council and kindly shared their memories of how independent companies, in mid-2020, worked together in the creation of a set of packages developed to support the clinical reporting pipeline. -If you are not familiar with this pipeline, you just need to know that, in a nutshell, pharmaceutical companies must follow a bunch of standardized procedures and formats when submitting clinical results to Health Authorities. -Remember that: **different** companies seeking the **same** standards of outputs. +If you are not familiar with this pipeline, you just need to know that, in a nutshell, pharmaceutical companies must follow a bunch of standardized procedures and formats (from Clinical Data Interchange Standards Consortium, [CDISC](https://www.cdisc.org/)) when submitting clinical results to Health Authorities. +Focus on this: **different** companies seeking the **same** standards of outputs. -And paraphrasing Ross presentation in [R/PHARMA 2022](https://www.youtube.com/watch?v=APMDOS4v9Hk), I'd like also to point out that, thinking of the development of a new drug, we are talking about a "post-competitive" scenario, where the drug was already discovered and we "only" must produce and deliver results. +Paraphrasing Ross presentation in [R/Pharma 2022](https://www.youtube.com/watch?v=APMDOS4v9Hk) and thinking of the development of a new drug, we are talking about a "post-competitive" scenario: the drug has already been discovered and the companies should "just" produce and deliver standardized results. -More precisely, +Rationally, we can say that companies face the same challenges in these steps of the process. +Irrationally, we can also say they were working in silos on that. +Just as Isaac Newton and Gottfried W. Leibniz [independently developed the theory of infinitesimal calculus](https://en.wikipedia.org/wiki/History_of_calculus), pharmaceutical companies were also independently working on R solutions for this pipeline. + +But in 2018, more precisely in August 16 and 17, they gathered at the first edition of [R/Pharma conference](https://rinpharma.com/) to discuss R and open-source tooling for drug development (the reasons why open-source is a more advantageous approach can be found in this [post](https://pharmaverse.github.io/blog/posts/2023-07-20_cross_company_dev/cross_industry_dev.html) written by Stefan Thoma). +And according to Isabela Velásquez's article, [Pharmaverse: Packages for clinical reporting workflows](https://posit.co/blog/pharmaverse-packages-for-clinical-reporting-workflows/), one of the most popular questions in the conference was "Is the package code available or on [CRAN](https://cran.r-project.org/)?". + +Well, many of them, just to mention a few, were (not necessarily at that date): [*pharmaRTF*](https://atorus-research.github.io/pharmaRTF/index.html) and [*Tplyr*](https://atorus-research.github.io/Tplyr/index.html) from Atorus, [*r2rtf*](https://merck.github.io/r2rtf/) from Merck, [*rtables*](https://insightsengineering.github.io/rtables/main/) from Roche, and etc. +So were almost 10000 other packages (today, almost 20000). +And that took to another two questions: + +1. With this stifling and overwhelming number of packages on CRAN, how to find the ones related to "clinical reporting problems"? + +2. Once the packages were found, how to choose which one to use among those that have the same functional purpose? + +Again, companies were working in silos to find those answers. +But now, in collaborative silos and with common goals: create extremely useful packages to solve pharmaceutical-specific gaps once and solve them well! + +From Stackhouse's report, Mike Rimler and he talked and ultimately formed a partnership between GSK and Atorus to develop a few more packages, including [metacore](https://github.com/atorus-research/metacore), [xportr](https://github.com/atorus-research/xportr), and timber (which became [logrx](https://github.com/pharmaverse/logrx). + +Around the same time, Thomas Neitmann (actual Denali Therapeutics, ex-Roche) and Rimler discovered that both were working with ADaM in R, so Ross and Rimler saw an opportunity there and GSK started their partnership with Roche to build and release [admiral](https://github.com/pharmaverse/admiral) package. + +The idea of working together, the sense of community, and the appetite from organizations built more and more, with incentive and priority established up into the programming heads council. + +Janssen had a huge effort in building R capabilities going on as well, by releasing [tidytlg](https://github.com/pharmaverse/tidytlg) and [envsetup](https://github.com/pharmaverse/envsetup)), so eventually Rimler, Stackhouse and Ross formalized [pharmaverse](https://pharmaverse.org/) and formed the council, adding in Sumesh (Janssen). + +At the end of their presentation ["Closing the Gap: Creating an End to End R Package Toolkit for the Clinical Reporting Pipeline."](https://www.youtube.com/watch?v=NW9qp5QOlIU), in [R/Pharma 2021](https://rinpharma.com/event/rinpharma2021/), Ben Straub's (GSK) and Eli Miller's (Atorus) welcomed the community to the [pharmaverse](https://pharmaverse.org/), a new group of packages developed by various pharmaceutical companies to support open-source clinical workflows. From e237c2ca0487436db1a38588a8161ae2b839355d Mon Sep 17 00:00:00 2001 From: Nicholas Eugenio Date: Thu, 17 Aug 2023 21:09:46 +0000 Subject: [PATCH 04/15] Version to Review --- inst/WORDLIST.txt | 32 ++++++++++++++++++ posts/2023-08-30_pharmaverse_story/logos.png | Bin 0 -> 343383 bytes .../pharmaverse_story.qmd | 29 ++++++++++------ 3 files changed, 51 insertions(+), 10 deletions(-) create mode 100644 posts/2023-08-30_pharmaverse_story/logos.png diff --git a/inst/WORDLIST.txt b/inst/WORDLIST.txt index fa9a91d8..5e97ad99 100644 --- a/inst/WORDLIST.txt +++ b/inst/WORDLIST.txt @@ -252,3 +252,35 @@ tlg TLG TLGs xpt +APMDOS +atorus +Atorus +britannica +dev +Encyclopædia +envsetup +Farrugia +Gottfried +Hk +Isabela +Janssen +Kalappurakal +logrx +merck +metacore +Pharma +pharmaRTF +phuse +QOlIU +qp +Rimler +rinpharma +rtf +Stackhouse +Stackhouse's +Straub's +Sumesh +tidytlg +Tplyr +Velásquez's +youtube diff --git a/posts/2023-08-30_pharmaverse_story/logos.png 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z$2IZF?%j1KPuA4d-t(Eyh+YyB67T14-`cgWrT%jZmp@y(QS_3Kka$0dwqK_D-zH~l zRu*p+z3xaP@o}xdjgm_EB_ys6%W;JCnn*}o9gfBLag6R{B=I33At50lA#qcYMt+o# zkdTm&khrNx;zL40LPA19;-(^r4+#kg2?+^_n~EepBqSsxBqStmDw6n+kdTm&kdU~k xNa906LPA19LgJ<(i4O@02?+@aiJJ(9{eMu;>OF0xuz&yn002ovPDHLkV1jUo0}}uM literal 0 HcmV?d00001 diff --git a/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd b/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd index 4fb848ec..e28c032d 100644 --- a/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd +++ b/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd @@ -1,5 +1,5 @@ --- -title: "pharmaverse (hi)story" +title: "The pharmaverse (hi)story" author: - name: Nicholas Eugenio description: "" @@ -20,7 +20,7 @@ long_slug <- "2023-08-30_pharmaverse_story" -**Story** +**Pharmaverse: from motivation to present** Since the Australian Aboriginal, the earliest peoples recorded to have inhabited the Earth and who have been in Australia for at least 65,000 to 80,000 years ([Encyclopædia Britannica](https://www.britannica.com/topic/Australian-Aboriginal)), human beings live in group. Whether to protect yourself, increase your life expectancy or simply share tasks. @@ -36,27 +36,27 @@ I can't disagree with him. And I dare say that Michael Rimler (GSK), Mike Stackhouse (Atorus), Ross Farrugia (Roche), and Sumesh Kalappurakal (Janssen) agree with me. They are the founders of [pharmaverse](https://pharmaverse.org/), members of its Council and kindly shared their memories of how independent companies, in mid-2020, worked together in the creation of a set of packages developed to support the clinical reporting pipeline. -If you are not familiar with this pipeline, you just need to know that, in a nutshell, pharmaceutical companies must follow a bunch of standardized procedures and formats (from Clinical Data Interchange Standards Consortium, [CDISC](https://www.cdisc.org/)) when submitting clinical results to Health Authorities. -Focus on this: **different** companies seeking the **same** standards of outputs. +If you are not familiar with this pipeline, the important thing to know is that, in a nutshell, pharmaceutical companies must follow a bunch of standardized procedures and formats (from Clinical Data Interchange Standards Consortium, [CDISC](https://www.cdisc.org/)) when submitting clinical results to Health Authorities. +Focus on this: **different** companies seeking the **same** standards for outputs. Paraphrasing Ross presentation in [R/Pharma 2022](https://www.youtube.com/watch?v=APMDOS4v9Hk) and thinking of the development of a new drug, we are talking about a "post-competitive" scenario: the drug has already been discovered and the companies should "just" produce and deliver standardized results. Rationally, we can say that companies face the same challenges in these steps of the process. Irrationally, we can also say they were working in silos on that. -Just as Isaac Newton and Gottfried W. Leibniz [independently developed the theory of infinitesimal calculus](https://en.wikipedia.org/wiki/History_of_calculus), pharmaceutical companies were also independently working on R solutions for this pipeline. +Just as Isaac Newton and Gottfried W. Leibniz [independently developed the theory of infinitesimal calculus](https://en.wikipedia.org/wiki/History_of_calculus), pharmaceutical companies were independently working on R solutions for this pipeline. -But in 2018, more precisely in August 16 and 17, they gathered at the first edition of [R/Pharma conference](https://rinpharma.com/) to discuss R and open-source tooling for drug development (the reasons why open-source is a more advantageous approach can be found in this [post](https://pharmaverse.github.io/blog/posts/2023-07-20_cross_company_dev/cross_industry_dev.html) written by Stefan Thoma). -And according to Isabela Velásquez's article, [Pharmaverse: Packages for clinical reporting workflows](https://posit.co/blog/pharmaverse-packages-for-clinical-reporting-workflows/), one of the most popular questions in the conference was "Is the package code available or on [CRAN](https://cran.r-project.org/)?". +But in 2018, more precisely in August 16 and 17, they gathered at the first edition of [R/Pharma conference](https://rinpharma.com/) to discuss R and open-source tooling for drug development (the reasons why open-source is an advantageous approach can be found in this [post](https://pharmaverse.github.io/blog/posts/2023-07-20_cross_company_dev/cross_industry_dev.html) written by Stefan Thoma). +And according to Isabela Velásquez's article, [Pharmaverse: Packages for clinical reporting workflows](https://posit.co/blog/pharmaverse-packages-for-clinical-reporting-workflows/), one of the most popular questions in this conference was "Is the package code available or on [CRAN](https://cran.r-project.org/)?". -Well, many of them, just to mention a few, were (not necessarily at that date): [*pharmaRTF*](https://atorus-research.github.io/pharmaRTF/index.html) and [*Tplyr*](https://atorus-research.github.io/Tplyr/index.html) from Atorus, [*r2rtf*](https://merck.github.io/r2rtf/) from Merck, [*rtables*](https://insightsengineering.github.io/rtables/main/) from Roche, and etc. -So were almost 10000 other packages (today, almost 20000). +Well, many of them were. And not necessarily at that date, but just to mention a few: [*pharmaRTF*](https://atorus-research.github.io/pharmaRTF/index.html) and [*Tplyr*](https://atorus-research.github.io/Tplyr/index.html) from Atorus, [*r2rtf*](https://merck.github.io/r2rtf/) from Merck, [*rtables*](https://insightsengineering.github.io/rtables/main/) from Roche, and etc. +The thing is that were almost 10000 other packages as well (today, almost 20000). And that took to another two questions: 1. With this stifling and overwhelming number of packages on CRAN, how to find the ones related to "clinical reporting problems"? 2. Once the packages were found, how to choose which one to use among those that have the same functional purpose? -Again, companies were working in silos to find those answers. +So, again, companies re-started to working in silos to find those answers. But now, in collaborative silos and with common goals: create extremely useful packages to solve pharmaceutical-specific gaps once and solve them well! From Stackhouse's report, Mike Rimler and he talked and ultimately formed a partnership between GSK and Atorus to develop a few more packages, including [metacore](https://github.com/atorus-research/metacore), [xportr](https://github.com/atorus-research/xportr), and timber (which became [logrx](https://github.com/pharmaverse/logrx). @@ -69,6 +69,15 @@ Janssen had a huge effort in building R capabilities going on as well, by releas At the end of their presentation ["Closing the Gap: Creating an End to End R Package Toolkit for the Clinical Reporting Pipeline."](https://www.youtube.com/watch?v=NW9qp5QOlIU), in [R/Pharma 2021](https://rinpharma.com/event/rinpharma2021/), Ben Straub's (GSK) and Eli Miller's (Atorus) welcomed the community to the [pharmaverse](https://pharmaverse.org/), a new group of packages developed by various pharmaceutical companies to support open-source clinical workflows. +From the outset, the name [pharmaverse](https://pharmaverse.org/) was chosen so that it could be a neutral home, unrelated to any company. Also, it was established as not being a consortium, which means that founders don’t own, fund, or maintain the packages. Some individuals and companies maintain them but don’t take ownership of them. The focus of [pharmaverse](https://pharmaverse.org/) early on, and today, is on inter organization cooperation, to build an environment where, if organizations identify that they have a joint problem that they want to solve, this is the right space to work on and release it. + +[Pharmaverse](https://pharmaverse.org/) has grown a lot, at the time of writing this post we have 75 packages hosted in [pharmaverse](https://pharmaverse.org/) [CRAN-like instance](https://pharmaverse.r-universe.dev/builds), and this has lead to a partnership with [PHUSE](https://phuse.global/About_PHUSE) to get support from their organization and platform, and because they are eager to advance and support [pharmaverse](https://pharmaverse.org/) mission. + +Despite all its structure, it is impossible to say that we have a single solution for each clinical reporting analysis when it comes to [pharmaverse](https://pharmaverse.org/), a single pathway is impractical. Instead, it is necessary to accept viable tools fitting different pathways into [pharmaverse](https://pharmaverse.org/) to direct and give people options as to what might work for them. After all, even though we live together as a community, we still have our own unique internal problems. + +![Sample of pharmaverse packages](logos.png) + + ```{r, echo=FALSE} From 3d6edbe8ad3dad0dd43eaf4b96bb27df685c7718 Mon Sep 17 00:00:00 2001 From: Nicholas Eugenio Date: Thu, 17 Aug 2023 21:31:46 +0000 Subject: [PATCH 05/15] appendix --- posts/2023-08-30_pharmaverse_story/appendix.R | 78 +++++++++++++++++++ 1 file changed, 78 insertions(+) diff --git a/posts/2023-08-30_pharmaverse_story/appendix.R b/posts/2023-08-30_pharmaverse_story/appendix.R index e69de29b..946a007a 100644 --- a/posts/2023-08-30_pharmaverse_story/appendix.R +++ b/posts/2023-08-30_pharmaverse_story/appendix.R @@ -0,0 +1,78 @@ +# markdown helpers -------------------------------------------------------- + +markdown_appendix <- function(name, content) { + paste(paste("##", name, "{.appendix}"), " ", content, sep = "\n") +} +markdown_link <- function(text, path) { + paste0("[", text, "](", path, ")") +} + + + +# worker functions -------------------------------------------------------- + +insert_source <- function(repo_spec, name, + collection = "posts", + branch = "main", + host = "https://github.com", + text = "source code") { + path <- paste( + host, + repo_spec, + "tree", + branch, + collection, + name, + "index.qmd", + sep = "/" + ) + return(markdown_link(text, path)) +} + +insert_timestamp <- function(tzone = Sys.timezone()) { + time <- lubridate::now(tzone = tzone) + stamp <- as.character(time, tz = tzone, usetz = TRUE) + return(stamp) +} + +insert_lockfile <- function(repo_spec, name, + collection = "posts", + branch = "main", + host = "https://github.com", + text = "R environment") { + path <- paste( + host, + repo_spec, + "tree", + branch, + collection, + name, + "renv.lock", + sep = "/" + ) + return(markdown_link(text, path)) +} + + + +# top level function ------------------------------------------------------ + +insert_appendix <- function(repo_spec, name, collection = "posts") { + appendices <- paste( + markdown_appendix( + name = "Last updated", + content = insert_timestamp() + ), + " ", + markdown_appendix( + name = "Details", + content = paste( + insert_source(repo_spec, name, collection), + insert_lockfile(repo_spec, name, collection), + sep = ", " + ) + ), + sep = "\n" + ) + knitr::asis_output(appendices) +} From 7c2d6b7be87a95de6a92a95b0584bfa4c2f490e1 Mon Sep 17 00:00:00 2001 From: Nicholas Eugenio Date: Thu, 17 Aug 2023 21:34:58 +0000 Subject: [PATCH 06/15] Space between image --- posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd | 1 + 1 file changed, 1 insertion(+) diff --git a/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd b/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd index e28c032d..a252a962 100644 --- a/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd +++ b/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd @@ -75,6 +75,7 @@ From the outset, the name [pharmaverse](https://pharmaverse.org/) was chosen so Despite all its structure, it is impossible to say that we have a single solution for each clinical reporting analysis when it comes to [pharmaverse](https://pharmaverse.org/), a single pathway is impractical. Instead, it is necessary to accept viable tools fitting different pathways into [pharmaverse](https://pharmaverse.org/) to direct and give people options as to what might work for them. After all, even though we live together as a community, we still have our own unique internal problems. + ![Sample of pharmaverse packages](logos.png) From c9a4e4a38dc804eaba7c0e4b097caabbf325958b Mon Sep 17 00:00:00 2001 From: Nicholas Eugenio Date: Fri, 18 Aug 2023 13:59:09 +0000 Subject: [PATCH 07/15] Formatting packages names --- .../pharmaverse_story.qmd | 22 +++++++++++-------- 1 file changed, 13 insertions(+), 9 deletions(-) diff --git a/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd b/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd index a252a962..e66ddd59 100644 --- a/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd +++ b/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd @@ -48,7 +48,8 @@ Just as Isaac Newton and Gottfried W. Leibniz [independently developed the theor But in 2018, more precisely in August 16 and 17, they gathered at the first edition of [R/Pharma conference](https://rinpharma.com/) to discuss R and open-source tooling for drug development (the reasons why open-source is an advantageous approach can be found in this [post](https://pharmaverse.github.io/blog/posts/2023-07-20_cross_company_dev/cross_industry_dev.html) written by Stefan Thoma). And according to Isabela Velásquez's article, [Pharmaverse: Packages for clinical reporting workflows](https://posit.co/blog/pharmaverse-packages-for-clinical-reporting-workflows/), one of the most popular questions in this conference was "Is the package code available or on [CRAN](https://cran.r-project.org/)?". -Well, many of them were. And not necessarily at that date, but just to mention a few: [*pharmaRTF*](https://atorus-research.github.io/pharmaRTF/index.html) and [*Tplyr*](https://atorus-research.github.io/Tplyr/index.html) from Atorus, [*r2rtf*](https://merck.github.io/r2rtf/) from Merck, [*rtables*](https://insightsengineering.github.io/rtables/main/) from Roche, and etc. +Well, many of them were. +And not necessarily at that date, but just to mention a few: [*pharmaRTF*](https://atorus-research.github.io/pharmaRTF/index.html) and [*Tplyr*](https://atorus-research.github.io/Tplyr/index.html) from Atorus, [*r2rtf*](https://merck.github.io/r2rtf/) from Merck, [*rtables*](https://insightsengineering.github.io/rtables/main/) from Roche, and etc. The thing is that were almost 10000 other packages as well (today, almost 20000). And that took to another two questions: @@ -59,26 +60,29 @@ And that took to another two questions: So, again, companies re-started to working in silos to find those answers. But now, in collaborative silos and with common goals: create extremely useful packages to solve pharmaceutical-specific gaps once and solve them well! -From Stackhouse's report, Mike Rimler and he talked and ultimately formed a partnership between GSK and Atorus to develop a few more packages, including [metacore](https://github.com/atorus-research/metacore), [xportr](https://github.com/atorus-research/xportr), and timber (which became [logrx](https://github.com/pharmaverse/logrx). +From Stackhouse's report, Mike Rimler and he talked and ultimately formed a partnership between GSK and Atorus to develop a few more packages, including [*metacore*](https://github.com/atorus-research/metacore), [*xportr*](https://github.com/atorus-research/xportr), and *timber* (which became [*logrx*](https://github.com/pharmaverse/logrx). -Around the same time, Thomas Neitmann (actual Denali Therapeutics, ex-Roche) and Rimler discovered that both were working with ADaM in R, so Ross and Rimler saw an opportunity there and GSK started their partnership with Roche to build and release [admiral](https://github.com/pharmaverse/admiral) package. +Around the same time, Thomas Neitmann (actual Denali Therapeutics, ex-Roche) and Rimler discovered that both were working with ADaM in R, so Ross and Rimler saw an opportunity there and GSK started their partnership with Roche to build and release [*admiral*](https://github.com/pharmaverse/admiral) package. The idea of working together, the sense of community, and the appetite from organizations built more and more, with incentive and priority established up into the programming heads council. -Janssen had a huge effort in building R capabilities going on as well, by releasing [tidytlg](https://github.com/pharmaverse/tidytlg) and [envsetup](https://github.com/pharmaverse/envsetup)), so eventually Rimler, Stackhouse and Ross formalized [pharmaverse](https://pharmaverse.org/) and formed the council, adding in Sumesh (Janssen). +Janssen had a huge effort in building R capabilities going on as well, by releasing [*tidytlg*](https://github.com/pharmaverse/tidytlg) and [*envsetup*](https://github.com/pharmaverse/envsetup)), so eventually Rimler, Stackhouse and Ross formalized [pharmaverse](https://pharmaverse.org/) and formed the council, adding in Sumesh (Janssen). At the end of their presentation ["Closing the Gap: Creating an End to End R Package Toolkit for the Clinical Reporting Pipeline."](https://www.youtube.com/watch?v=NW9qp5QOlIU), in [R/Pharma 2021](https://rinpharma.com/event/rinpharma2021/), Ben Straub's (GSK) and Eli Miller's (Atorus) welcomed the community to the [pharmaverse](https://pharmaverse.org/), a new group of packages developed by various pharmaceutical companies to support open-source clinical workflows. -From the outset, the name [pharmaverse](https://pharmaverse.org/) was chosen so that it could be a neutral home, unrelated to any company. Also, it was established as not being a consortium, which means that founders don’t own, fund, or maintain the packages. Some individuals and companies maintain them but don’t take ownership of them. The focus of [pharmaverse](https://pharmaverse.org/) early on, and today, is on inter organization cooperation, to build an environment where, if organizations identify that they have a joint problem that they want to solve, this is the right space to work on and release it. +From the outset, the name [pharmaverse](https://pharmaverse.org/) was chosen so that it could be a neutral home, unrelated to any company. +Also, it was established as not being a consortium, which means that founders don't own, fund, or maintain the packages. +Some individuals and companies maintain them but don't take ownership of them. +The focus of [pharmaverse](https://pharmaverse.org/) early on, and today, is on inter organization cooperation, to build an environment where, if organizations identify that they have a joint problem that they want to solve, this is the right space to work on and release it. -[Pharmaverse](https://pharmaverse.org/) has grown a lot, at the time of writing this post we have 75 packages hosted in [pharmaverse](https://pharmaverse.org/) [CRAN-like instance](https://pharmaverse.r-universe.dev/builds), and this has lead to a partnership with [PHUSE](https://phuse.global/About_PHUSE) to get support from their organization and platform, and because they are eager to advance and support [pharmaverse](https://pharmaverse.org/) mission. - -Despite all its structure, it is impossible to say that we have a single solution for each clinical reporting analysis when it comes to [pharmaverse](https://pharmaverse.org/), a single pathway is impractical. Instead, it is necessary to accept viable tools fitting different pathways into [pharmaverse](https://pharmaverse.org/) to direct and give people options as to what might work for them. After all, even though we live together as a community, we still have our own unique internal problems. +[Pharmaverse](https://pharmaverse.org/) has grown a lot, at the time of writing this post we have 75 packages hosted in [pharmaverse](https://pharmaverse.org/) [CRAN-like instance](https://pharmaverse.r-universe.dev/builds), and this has lead to a partnership with [PHUSE](https://phuse.global/About_PHUSE) to get support from their organization and platform, and because they are eager to advance and support [pharmaverse](https://pharmaverse.org/) mission. +Despite all its structure, it is impossible to say that we have a single solution for each clinical reporting analysis when it comes to [pharmaverse](https://pharmaverse.org/), a single pathway is impractical. +Instead, it is necessary to accept viable tools fitting different pathways into [pharmaverse](https://pharmaverse.org/) to direct and give people options as to what might work for them. +After all, even though we live together as a community, we still have our own unique internal problems. ![Sample of pharmaverse packages](logos.png) - ```{r, echo=FALSE} From ab6c33d88abbac7ac914798915c16de3e30ef105 Mon Sep 17 00:00:00 2001 From: Nicholas Eugenio Date: Fri, 18 Aug 2023 18:33:28 +0000 Subject: [PATCH 08/15] Grammar mistakes --- posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd | 6 +++--- 1 file changed, 3 insertions(+), 3 deletions(-) diff --git a/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd b/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd index e66ddd59..284ac138 100644 --- a/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd +++ b/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd @@ -33,7 +33,7 @@ For most aspects of life, it doesn't make sense to think, act or work alone for The English poet John Donne used to say *"No man is an island entire of itself; every man is a piece of the continent, a part of the main;"*. I can't disagree with him. -And I dare say that Michael Rimler (GSK), Mike Stackhouse (Atorus), Ross Farrugia (Roche), and Sumesh Kalappurakal (Janssen) agree with me. +And I dare say that Michael Rimler (GSK), Michael Stackhouse (Atorus), Ross Farrugia (Roche), and Sumesh Kalappurakal (Janssen) agree with me. They are the founders of [pharmaverse](https://pharmaverse.org/), members of its Council and kindly shared their memories of how independent companies, in mid-2020, worked together in the creation of a set of packages developed to support the clinical reporting pipeline. If you are not familiar with this pipeline, the important thing to know is that, in a nutshell, pharmaceutical companies must follow a bunch of standardized procedures and formats (from Clinical Data Interchange Standards Consortium, [CDISC](https://www.cdisc.org/)) when submitting clinical results to Health Authorities. @@ -60,7 +60,7 @@ And that took to another two questions: So, again, companies re-started to working in silos to find those answers. But now, in collaborative silos and with common goals: create extremely useful packages to solve pharmaceutical-specific gaps once and solve them well! -From Stackhouse's report, Mike Rimler and he talked and ultimately formed a partnership between GSK and Atorus to develop a few more packages, including [*metacore*](https://github.com/atorus-research/metacore), [*xportr*](https://github.com/atorus-research/xportr), and *timber* (which became [*logrx*](https://github.com/pharmaverse/logrx). +From Stackhouse's report, Michael Rimler and he talked and ultimately formed a partnership between GSK and Atorus to develop a few more packages, including [*metacore*](https://github.com/atorus-research/metacore), [*xportr*](https://github.com/atorus-research/xportr), and *timber* (which became [*logrx*](https://github.com/pharmaverse/logrx). Around the same time, Thomas Neitmann (actual Denali Therapeutics, ex-Roche) and Rimler discovered that both were working with ADaM in R, so Ross and Rimler saw an opportunity there and GSK started their partnership with Roche to build and release [*admiral*](https://github.com/pharmaverse/admiral) package. @@ -75,7 +75,7 @@ Also, it was established as not being a consortium, which means that founders do Some individuals and companies maintain them but don't take ownership of them. The focus of [pharmaverse](https://pharmaverse.org/) early on, and today, is on inter organization cooperation, to build an environment where, if organizations identify that they have a joint problem that they want to solve, this is the right space to work on and release it. -[Pharmaverse](https://pharmaverse.org/) has grown a lot, at the time of writing this post we have 75 packages hosted in [pharmaverse](https://pharmaverse.org/) [CRAN-like instance](https://pharmaverse.r-universe.dev/builds), and this has lead to a partnership with [PHUSE](https://phuse.global/About_PHUSE) to get support from their organization and platform, and because they are eager to advance and support [pharmaverse](https://pharmaverse.org/) mission. +[Pharmaverse](https://pharmaverse.org/) has grown a lot, at the time of writing this post we have 75 packages hosted in [pharmaverse](https://pharmaverse.org/) [CRAN-like instance](https://pharmaverse.r-universe.dev/builds), and this has led to a partnership with [PHUSE](https://phuse.global/About_PHUSE) to get support from their organization and platform, and because they are eager to advance and support [pharmaverse](https://pharmaverse.org/) mission. Despite all its structure, it is impossible to say that we have a single solution for each clinical reporting analysis when it comes to [pharmaverse](https://pharmaverse.org/), a single pathway is impractical. Instead, it is necessary to accept viable tools fitting different pathways into [pharmaverse](https://pharmaverse.org/) to direct and give people options as to what might work for them. From 58449e5aa556f9b37fdb52ff5503f7753b3e2d5d Mon Sep 17 00:00:00 2001 From: Nicholas W Eugenio Date: Mon, 21 Aug 2023 09:44:03 -0300 Subject: [PATCH 09/15] Apply suggestions from code review (Ross Farrugia) Co-authored-by: Ross Farrugia <82581364+rossfarrugia@users.noreply.github.com> --- posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd b/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd index 284ac138..d930857e 100644 --- a/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd +++ b/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd @@ -72,10 +72,10 @@ At the end of their presentation ["Closing the Gap: Creating an End to End R Pac From the outset, the name [pharmaverse](https://pharmaverse.org/) was chosen so that it could be a neutral home, unrelated to any company. Also, it was established as not being a consortium, which means that founders don't own, fund, or maintain the packages. -Some individuals and companies maintain them but don't take ownership of them. +Some individuals and companies maintain them but often allowing for community contributions and being licensed permissively so that there is always a feeling of community ownership. The focus of [pharmaverse](https://pharmaverse.org/) early on, and today, is on inter organization cooperation, to build an environment where, if organizations identify that they have a joint problem that they want to solve, this is the right space to work on and release it. -[Pharmaverse](https://pharmaverse.org/) has grown a lot, at the time of writing this post we have 75 packages hosted in [pharmaverse](https://pharmaverse.org/) [CRAN-like instance](https://pharmaverse.r-universe.dev/builds), and this has led to a partnership with [PHUSE](https://phuse.global/About_PHUSE) to get support from their organization and platform, and because they are eager to advance and support [pharmaverse](https://pharmaverse.org/) mission. +[Pharmaverse](https://pharmaverse.org/) has grown a lot, at the time of writing this post we have >25 packages recommended in [pharmaverse](https://pharmaverse.org/e2eclinical/), and this has led to a partnership with [PHUSE](https://phuse.global/About_PHUSE) to get support from their organization and platform, and because they are eager to advance and support [pharmaverse mission](https://pharmaverse.org/charter/). Despite all its structure, it is impossible to say that we have a single solution for each clinical reporting analysis when it comes to [pharmaverse](https://pharmaverse.org/), a single pathway is impractical. Instead, it is necessary to accept viable tools fitting different pathways into [pharmaverse](https://pharmaverse.org/) to direct and give people options as to what might work for them. From 96ba171ff217c8f7cade159d83bc94d64a41debd Mon Sep 17 00:00:00 2001 From: Nicholas Eugenio Date: Mon, 21 Aug 2023 12:47:55 +0000 Subject: [PATCH 10/15] Adding Ari Siggaard Knoph (Novo Nordisk) as a council member. --- posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd b/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd index d930857e..a378145a 100644 --- a/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd +++ b/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd @@ -66,7 +66,7 @@ Around the same time, Thomas Neitmann (actual Denali Therapeutics, ex-Roche) and The idea of working together, the sense of community, and the appetite from organizations built more and more, with incentive and priority established up into the programming heads council. -Janssen had a huge effort in building R capabilities going on as well, by releasing [*tidytlg*](https://github.com/pharmaverse/tidytlg) and [*envsetup*](https://github.com/pharmaverse/envsetup)), so eventually Rimler, Stackhouse and Ross formalized [pharmaverse](https://pharmaverse.org/) and formed the council, adding in Sumesh (Janssen). +Janssen had a huge effort in building R capabilities going on as well, by releasing [*tidytlg*](https://github.com/pharmaverse/tidytlg) and [*envsetup*](https://github.com/pharmaverse/envsetup)), so eventually Rimler, Stackhouse and Ross formalized [pharmaverse](https://pharmaverse.org/) and formed the council, adding in Sumesh (Janssen) and Ari Siggaard Knoph (Novo Nordisk) later joined as the fifth council member.. At the end of their presentation ["Closing the Gap: Creating an End to End R Package Toolkit for the Clinical Reporting Pipeline."](https://www.youtube.com/watch?v=NW9qp5QOlIU), in [R/Pharma 2021](https://rinpharma.com/event/rinpharma2021/), Ben Straub's (GSK) and Eli Miller's (Atorus) welcomed the community to the [pharmaverse](https://pharmaverse.org/), a new group of packages developed by various pharmaceutical companies to support open-source clinical workflows. From e0b06111e41218b997632bf57817939da5a364e7 Mon Sep 17 00:00:00 2001 From: Nicholas Eugenio Date: Mon, 21 Aug 2023 12:52:57 +0000 Subject: [PATCH 11/15] Wordlist --- inst/WORDLIST.txt | 6 ++++++ 1 file changed, 6 insertions(+) diff --git a/inst/WORDLIST.txt b/inst/WORDLIST.txt index 7920a4f7..aec5ff9c 100644 --- a/inst/WORDLIST.txt +++ b/inst/WORDLIST.txt @@ -317,3 +317,9 @@ dy lubridate TRTSDTM ymd +Ari +eclinical +Knoph +Nordisk +Novo +Siggaard From a0fb273b17d8c6531bb5a1d07a2ced14f6af2d70 Mon Sep 17 00:00:00 2001 From: Nicholas Eugenio Date: Mon, 21 Aug 2023 20:28:58 +0000 Subject: [PATCH 12/15] Ben's suggestions --- .../pharmaverse_story.qmd | 12 ++++++------ 1 file changed, 6 insertions(+), 6 deletions(-) diff --git a/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd b/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd index a378145a..fe66c7e1 100644 --- a/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd +++ b/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd @@ -20,7 +20,7 @@ long_slug <- "2023-08-30_pharmaverse_story" -**Pharmaverse: from motivation to present** +Pharmaverse: from motivation to present Since the Australian Aboriginal, the earliest peoples recorded to have inhabited the Earth and who have been in Australia for at least 65,000 to 80,000 years ([Encyclopædia Britannica](https://www.britannica.com/topic/Australian-Aboriginal)), human beings live in group. Whether to protect yourself, increase your life expectancy or simply share tasks. @@ -33,7 +33,7 @@ For most aspects of life, it doesn't make sense to think, act or work alone for The English poet John Donne used to say *"No man is an island entire of itself; every man is a piece of the continent, a part of the main;"*. I can't disagree with him. -And I dare say that Michael Rimler (GSK), Michael Stackhouse (Atorus), Ross Farrugia (Roche), and Sumesh Kalappurakal (Janssen) agree with me. +And I dare say that Ari Siggaard Knoph (Novo Nordisk), Michael Rimler (GSK), Michael Stackhouse (Atorus), Ross Farrugia (Roche), and Sumesh Kalappurakal (Janssen) can't disagree with him either. They are the founders of [pharmaverse](https://pharmaverse.org/), members of its Council and kindly shared their memories of how independent companies, in mid-2020, worked together in the creation of a set of packages developed to support the clinical reporting pipeline. If you are not familiar with this pipeline, the important thing to know is that, in a nutshell, pharmaceutical companies must follow a bunch of standardized procedures and formats (from Clinical Data Interchange Standards Consortium, [CDISC](https://www.cdisc.org/)) when submitting clinical results to Health Authorities. @@ -45,7 +45,7 @@ Rationally, we can say that companies face the same challenges in these steps of Irrationally, we can also say they were working in silos on that. Just as Isaac Newton and Gottfried W. Leibniz [independently developed the theory of infinitesimal calculus](https://en.wikipedia.org/wiki/History_of_calculus), pharmaceutical companies were independently working on R solutions for this pipeline. -But in 2018, more precisely in August 16 and 17, they gathered at the first edition of [R/Pharma conference](https://rinpharma.com/) to discuss R and open-source tooling for drug development (the reasons why open-source is an advantageous approach can be found in this [post](https://pharmaverse.github.io/blog/posts/2023-07-20_cross_company_dev/cross_industry_dev.html) written by Stefan Thoma). +But in 2018, on August 16 and 17, they gathered at the first edition of [R/Pharma conference](https://rinpharma.com/) to discuss R and open-source tooling for drug development (the reasons why open-source is an advantageous approach can be found in this [post](https://pharmaverse.github.io/blog/posts/2023-07-20_cross_company_dev/cross_industry_dev.html) written by Stefan Thoma). And according to Isabela Velásquez's article, [Pharmaverse: Packages for clinical reporting workflows](https://posit.co/blog/pharmaverse-packages-for-clinical-reporting-workflows/), one of the most popular questions in this conference was "Is the package code available or on [CRAN](https://cran.r-project.org/)?". Well, many of them were. @@ -53,20 +53,20 @@ And not necessarily at that date, but just to mention a few: [*pharmaRTF*](https The thing is that were almost 10000 other packages as well (today, almost 20000). And that took to another two questions: -1. With this stifling and overwhelming number of packages on CRAN, how to find the ones related to "clinical reporting problems"? +1. With this overwhelming number of packages on CRAN, how to find the ones related to solving "clinical reporting problems"? 2. Once the packages were found, how to choose which one to use among those that have the same functional purpose? So, again, companies re-started to working in silos to find those answers. But now, in collaborative silos and with common goals: create extremely useful packages to solve pharmaceutical-specific gaps once and solve them well! -From Stackhouse's report, Michael Rimler and he talked and ultimately formed a partnership between GSK and Atorus to develop a few more packages, including [*metacore*](https://github.com/atorus-research/metacore), [*xportr*](https://github.com/atorus-research/xportr), and *timber* (which became [*logrx*](https://github.com/pharmaverse/logrx). +In 2020, Michael Stackhouse and Michael Rimler talked and formed a partnership between Atorus and GSK to develop a few more packages, including [*metacore*](https://github.com/atorus-research/metacore), to read, store and manipulate metadata for ADaMs/SDTMs in a standardized object; [*xportr*](https://github.com/atorus-research/xportr), to create submission compliant SAS transport files and perform pharma specific dataset level validation checks; and [*logrx*](https://github.com/pharmaverse/logrx) (ex-*timber*), to build log to support reproducibility and traceability of an R script. Around the same time, Thomas Neitmann (actual Denali Therapeutics, ex-Roche) and Rimler discovered that both were working with ADaM in R, so Ross and Rimler saw an opportunity there and GSK started their partnership with Roche to build and release [*admiral*](https://github.com/pharmaverse/admiral) package. The idea of working together, the sense of community, and the appetite from organizations built more and more, with incentive and priority established up into the programming heads council. -Janssen had a huge effort in building R capabilities going on as well, by releasing [*tidytlg*](https://github.com/pharmaverse/tidytlg) and [*envsetup*](https://github.com/pharmaverse/envsetup)), so eventually Rimler, Stackhouse and Ross formalized [pharmaverse](https://pharmaverse.org/) and formed the council, adding in Sumesh (Janssen) and Ari Siggaard Knoph (Novo Nordisk) later joined as the fifth council member.. +Janssen had a huge effort in building R capabilities going on as well, by releasing [*tidytlg*](https://github.com/pharmaverse/tidytlg) and [*envsetup*](https://github.com/pharmaverse/envsetup)), so eventually Rimler, Stackhouse and Ross formalized [pharmaverse](https://pharmaverse.org/) and formed the council, adding in Sumesh (Janssen) and Ari Siggaard Knoph (Novo Nordisk) later joined as the fifth council member. At the end of their presentation ["Closing the Gap: Creating an End to End R Package Toolkit for the Clinical Reporting Pipeline."](https://www.youtube.com/watch?v=NW9qp5QOlIU), in [R/Pharma 2021](https://rinpharma.com/event/rinpharma2021/), Ben Straub's (GSK) and Eli Miller's (Atorus) welcomed the community to the [pharmaverse](https://pharmaverse.org/), a new group of packages developed by various pharmaceutical companies to support open-source clinical workflows. From 012b551268d0465b5113cb6318a861ba9a39253a Mon Sep 17 00:00:00 2001 From: Nicholas Eugenio Date: Mon, 21 Aug 2023 20:48:18 +0000 Subject: [PATCH 13/15] Adding sections --- inst/WORDLIST.txt | 2 ++ .../pharmaverse_story.qmd | 15 ++++++++++++--- 2 files changed, 14 insertions(+), 3 deletions(-) diff --git a/inst/WORDLIST.txt b/inst/WORDLIST.txt index aec5ff9c..2270d78e 100644 --- a/inst/WORDLIST.txt +++ b/inst/WORDLIST.txt @@ -323,3 +323,5 @@ Knoph Nordisk Novo Siggaard +pharma +reproducibility diff --git a/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd b/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd index fe66c7e1..8469ddf7 100644 --- a/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd +++ b/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd @@ -22,6 +22,8 @@ long_slug <- "2023-08-30_pharmaverse_story" Pharmaverse: from motivation to present +**Human history and pharmaverse context** + Since the Australian Aboriginal, the earliest peoples recorded to have inhabited the Earth and who have been in Australia for at least 65,000 to 80,000 years ([Encyclopædia Britannica](https://www.britannica.com/topic/Australian-Aboriginal)), human beings live in group. Whether to protect yourself, increase your life expectancy or simply share tasks. @@ -39,13 +41,15 @@ They are the founders of [pharmaverse](https://pharmaverse.org/), members of its If you are not familiar with this pipeline, the important thing to know is that, in a nutshell, pharmaceutical companies must follow a bunch of standardized procedures and formats (from Clinical Data Interchange Standards Consortium, [CDISC](https://www.cdisc.org/)) when submitting clinical results to Health Authorities. Focus on this: **different** companies seeking the **same** standards for outputs. -Paraphrasing Ross presentation in [R/Pharma 2022](https://www.youtube.com/watch?v=APMDOS4v9Hk) and thinking of the development of a new drug, we are talking about a "post-competitive" scenario: the drug has already been discovered and the companies should "just" produce and deliver standardized results. +Paraphrasing Ross *Breaking boundaries through open-source collaboration* presentation in [R/Pharma 2022](https://www.youtube.com/watch?v=APMDOS4v9Hk) and thinking of the development of a new drug, we are talking about a "post-competitive" scenario: the drug has already been discovered and the companies should "just" produce and deliver standardized results. + +**Clinical reporting outputs** Rationally, we can say that companies face the same challenges in these steps of the process. -Irrationally, we can also say they were working in silos on that. +Irrationally, we can also say they were working in silos on that before 2018. Just as Isaac Newton and Gottfried W. Leibniz [independently developed the theory of infinitesimal calculus](https://en.wikipedia.org/wiki/History_of_calculus), pharmaceutical companies were independently working on R solutions for this pipeline. -But in 2018, on August 16 and 17, they gathered at the first edition of [R/Pharma conference](https://rinpharma.com/) to discuss R and open-source tooling for drug development (the reasons why open-source is an advantageous approach can be found in this [post](https://pharmaverse.github.io/blog/posts/2023-07-20_cross_company_dev/cross_industry_dev.html) written by Stefan Thoma). +But on August 16 and 17 of the mentioned year above, they gathered at the first edition of [R/Pharma conference](https://rinpharma.com/) to discuss R and open-source tooling for drug development (the reasons why open-source is an advantageous approach can be found in this [post](https://pharmaverse.github.io/blog/posts/2023-07-20_cross_company_dev/cross_industry_dev.html) written by Stefan Thoma). And according to Isabela Velásquez's article, [Pharmaverse: Packages for clinical reporting workflows](https://posit.co/blog/pharmaverse-packages-for-clinical-reporting-workflows/), one of the most popular questions in this conference was "Is the package code available or on [CRAN](https://cran.r-project.org/)?". Well, many of them were. @@ -60,6 +64,8 @@ And that took to another two questions: So, again, companies re-started to working in silos to find those answers. But now, in collaborative silos and with common goals: create extremely useful packages to solve pharmaceutical-specific gaps once and solve them well! +**First partnerships** + In 2020, Michael Stackhouse and Michael Rimler talked and formed a partnership between Atorus and GSK to develop a few more packages, including [*metacore*](https://github.com/atorus-research/metacore), to read, store and manipulate metadata for ADaMs/SDTMs in a standardized object; [*xportr*](https://github.com/atorus-research/xportr), to create submission compliant SAS transport files and perform pharma specific dataset level validation checks; and [*logrx*](https://github.com/pharmaverse/logrx) (ex-*timber*), to build log to support reproducibility and traceability of an R script. Around the same time, Thomas Neitmann (actual Denali Therapeutics, ex-Roche) and Rimler discovered that both were working with ADaM in R, so Ross and Rimler saw an opportunity there and GSK started their partnership with Roche to build and release [*admiral*](https://github.com/pharmaverse/admiral) package. @@ -68,6 +74,8 @@ The idea of working together, the sense of community, and the appetite from orga Janssen had a huge effort in building R capabilities going on as well, by releasing [*tidytlg*](https://github.com/pharmaverse/tidytlg) and [*envsetup*](https://github.com/pharmaverse/envsetup)), so eventually Rimler, Stackhouse and Ross formalized [pharmaverse](https://pharmaverse.org/) and formed the council, adding in Sumesh (Janssen) and Ari Siggaard Knoph (Novo Nordisk) later joined as the fifth council member. +**Release, growth and developments** + At the end of their presentation ["Closing the Gap: Creating an End to End R Package Toolkit for the Clinical Reporting Pipeline."](https://www.youtube.com/watch?v=NW9qp5QOlIU), in [R/Pharma 2021](https://rinpharma.com/event/rinpharma2021/), Ben Straub's (GSK) and Eli Miller's (Atorus) welcomed the community to the [pharmaverse](https://pharmaverse.org/), a new group of packages developed by various pharmaceutical companies to support open-source clinical workflows. From the outset, the name [pharmaverse](https://pharmaverse.org/) was chosen so that it could be a neutral home, unrelated to any company. @@ -81,6 +89,7 @@ Despite all its structure, it is impossible to say that we have a single solutio Instead, it is necessary to accept viable tools fitting different pathways into [pharmaverse](https://pharmaverse.org/) to direct and give people options as to what might work for them. After all, even though we live together as a community, we still have our own unique internal problems. + ![Sample of pharmaverse packages](logos.png) From 03bf56e1a31d1eacf4ff793cdd1d77df321f5306 Mon Sep 17 00:00:00 2001 From: Nicholas W Eugenio Date: Tue, 22 Aug 2023 10:45:47 -0300 Subject: [PATCH 14/15] Apply suggestions from Stefan review Co-authored-by: StefanThoma <40463122+StefanThoma@users.noreply.github.com> --- inst/WORDLIST.txt | 3 --- posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd | 6 +++--- 2 files changed, 3 insertions(+), 6 deletions(-) diff --git a/inst/WORDLIST.txt b/inst/WORDLIST.txt index 2270d78e..f96d7043 100644 --- a/inst/WORDLIST.txt +++ b/inst/WORDLIST.txt @@ -277,14 +277,11 @@ Rimler rinpharma rtf Stackhouse -Stackhouse's -Straub's Sumesh tidytlg Tplyr Velásquez's youtube -======= admiraldev admiralRoche apache diff --git a/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd b/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd index 8469ddf7..021a294d 100644 --- a/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd +++ b/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd @@ -53,7 +53,7 @@ But on August 16 and 17 of the mentioned year above, they gathered at the first And according to Isabela Velásquez's article, [Pharmaverse: Packages for clinical reporting workflows](https://posit.co/blog/pharmaverse-packages-for-clinical-reporting-workflows/), one of the most popular questions in this conference was "Is the package code available or on [CRAN](https://cran.r-project.org/)?". Well, many of them were. -And not necessarily at that date, but just to mention a few: [*pharmaRTF*](https://atorus-research.github.io/pharmaRTF/index.html) and [*Tplyr*](https://atorus-research.github.io/Tplyr/index.html) from Atorus, [*r2rtf*](https://merck.github.io/r2rtf/) from Merck, [*rtables*](https://insightsengineering.github.io/rtables/main/) from Roche, and etc. +And not necessarily at that date, but just to mention a few: [*pharmaRTF*](https://atorus-research.github.io/pharmaRTF/index.html) and [*Tplyr*](https://atorus-research.github.io/Tplyr/index.html) from Atorus, [*r2rtf*](https://merck.github.io/r2rtf/) from Merck, [*rtables*](https://insightsengineering.github.io/rtables/main/) from Roche, etc. The thing is that were almost 10000 other packages as well (today, almost 20000). And that took to another two questions: @@ -68,7 +68,7 @@ But now, in collaborative silos and with common goals: create extremely useful p In 2020, Michael Stackhouse and Michael Rimler talked and formed a partnership between Atorus and GSK to develop a few more packages, including [*metacore*](https://github.com/atorus-research/metacore), to read, store and manipulate metadata for ADaMs/SDTMs in a standardized object; [*xportr*](https://github.com/atorus-research/xportr), to create submission compliant SAS transport files and perform pharma specific dataset level validation checks; and [*logrx*](https://github.com/pharmaverse/logrx) (ex-*timber*), to build log to support reproducibility and traceability of an R script. -Around the same time, Thomas Neitmann (actual Denali Therapeutics, ex-Roche) and Rimler discovered that both were working with ADaM in R, so Ross and Rimler saw an opportunity there and GSK started their partnership with Roche to build and release [*admiral*](https://github.com/pharmaverse/admiral) package. +Around the same time, Thomas Neitmann (currently at Denali Therapeutics, then at Roche) and Rimler discovered that both were working with ADaM in R, so Neitmann, Ross and Rimler saw an opportunity there and GSK started their partnership with Roche to build and release [*admiral*](https://github.com/pharmaverse/admiral) package. The idea of working together, the sense of community, and the appetite from organizations built more and more, with incentive and priority established up into the programming heads council. @@ -76,7 +76,7 @@ Janssen had a huge effort in building R capabilities going on as well, by releas **Release, growth and developments** -At the end of their presentation ["Closing the Gap: Creating an End to End R Package Toolkit for the Clinical Reporting Pipeline."](https://www.youtube.com/watch?v=NW9qp5QOlIU), in [R/Pharma 2021](https://rinpharma.com/event/rinpharma2021/), Ben Straub's (GSK) and Eli Miller's (Atorus) welcomed the community to the [pharmaverse](https://pharmaverse.org/), a new group of packages developed by various pharmaceutical companies to support open-source clinical workflows. +At the end of their presentation ["Closing the Gap: Creating an End to End R Package Toolkit for the Clinical Reporting Pipeline."](https://www.youtube.com/watch?v=NW9qp5QOlIU), in [R/Pharma 2021](https://rinpharma.com/event/rinpharma2021/), Ben Straub (GSK) and Eli Miller (Atorus) welcomed the community to the [pharmaverse](https://pharmaverse.org/), a curated collection of packages developed by various pharmaceutical companies to support open-source clinical workflows. From the outset, the name [pharmaverse](https://pharmaverse.org/) was chosen so that it could be a neutral home, unrelated to any company. Also, it was established as not being a consortium, which means that founders don't own, fund, or maintain the packages. From 459d1b92d3005b8e8b19728e2d377d7e4aa5ce20 Mon Sep 17 00:00:00 2001 From: Nicholas Eugenio Date: Tue, 22 Aug 2023 13:59:33 +0000 Subject: [PATCH 15/15] Stefan review --- .../pharmaverse_story.qmd | 25 +++++++++---------- 1 file changed, 12 insertions(+), 13 deletions(-) diff --git a/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd b/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd index 021a294d..ac740d0a 100644 --- a/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd +++ b/posts/2023-08-30_pharmaverse_story/pharmaverse_story.qmd @@ -22,7 +22,7 @@ long_slug <- "2023-08-30_pharmaverse_story" Pharmaverse: from motivation to present -**Human history and pharmaverse context** +## Human history and pharmaverse context Since the Australian Aboriginal, the earliest peoples recorded to have inhabited the Earth and who have been in Australia for at least 65,000 to 80,000 years ([Encyclopædia Britannica](https://www.britannica.com/topic/Australian-Aboriginal)), human beings live in group. Whether to protect yourself, increase your life expectancy or simply share tasks. @@ -39,14 +39,14 @@ And I dare say that Ari Siggaard Knoph (Novo Nordisk), Michael Rimler (GSK), Mic They are the founders of [pharmaverse](https://pharmaverse.org/), members of its Council and kindly shared their memories of how independent companies, in mid-2020, worked together in the creation of a set of packages developed to support the clinical reporting pipeline. If you are not familiar with this pipeline, the important thing to know is that, in a nutshell, pharmaceutical companies must follow a bunch of standardized procedures and formats (from Clinical Data Interchange Standards Consortium, [CDISC](https://www.cdisc.org/)) when submitting clinical results to Health Authorities. -Focus on this: **different** companies seeking the **same** standards for outputs. +The focus is on this: **different** companies seeking the **same** standards for outputs. -Paraphrasing Ross *Breaking boundaries through open-source collaboration* presentation in [R/Pharma 2022](https://www.youtube.com/watch?v=APMDOS4v9Hk) and thinking of the development of a new drug, we are talking about a "post-competitive" scenario: the drug has already been discovered and the companies should "just" produce and deliver standardized results. +Paraphrasing Ross Farrugia (Roche) *Breaking boundaries through open-source collaboration* presentation in [R/Pharma 2022](https://www.youtube.com/watch?v=APMDOS4v9Hk) and thinking of the development of a new drug, we are talking about a "post-competitive" scenario: the drug has already been discovered and the companies should "just" produce and deliver standardized results. -**Clinical reporting outputs** +## Clinical reporting outputs Rationally, we can say that companies face the same challenges in these steps of the process. -Irrationally, we can also say they were working in silos on that before 2018. +Not so intuitively, we can also say they were working in silos on that before 2018. Just as Isaac Newton and Gottfried W. Leibniz [independently developed the theory of infinitesimal calculus](https://en.wikipedia.org/wiki/History_of_calculus), pharmaceutical companies were independently working on R solutions for this pipeline. But on August 16 and 17 of the mentioned year above, they gathered at the first edition of [R/Pharma conference](https://rinpharma.com/) to discuss R and open-source tooling for drug development (the reasons why open-source is an advantageous approach can be found in this [post](https://pharmaverse.github.io/blog/posts/2023-07-20_cross_company_dev/cross_industry_dev.html) written by Stefan Thoma). @@ -54,7 +54,7 @@ And according to Isabela Velásquez's article, [Pharmaverse: Packages for clinic Well, many of them were. And not necessarily at that date, but just to mention a few: [*pharmaRTF*](https://atorus-research.github.io/pharmaRTF/index.html) and [*Tplyr*](https://atorus-research.github.io/Tplyr/index.html) from Atorus, [*r2rtf*](https://merck.github.io/r2rtf/) from Merck, [*rtables*](https://insightsengineering.github.io/rtables/main/) from Roche, etc. -The thing is that were almost 10000 other packages as well (today, almost 20000). +The thing is that, overall, there were almost 10000 other packages as well (today, almost 20000). And that took to another two questions: 1. With this overwhelming number of packages on CRAN, how to find the ones related to solving "clinical reporting problems"? @@ -64,17 +64,17 @@ And that took to another two questions: So, again, companies re-started to working in silos to find those answers. But now, in collaborative silos and with common goals: create extremely useful packages to solve pharmaceutical-specific gaps once and solve them well! -**First partnerships** +## First partnerships -In 2020, Michael Stackhouse and Michael Rimler talked and formed a partnership between Atorus and GSK to develop a few more packages, including [*metacore*](https://github.com/atorus-research/metacore), to read, store and manipulate metadata for ADaMs/SDTMs in a standardized object; [*xportr*](https://github.com/atorus-research/xportr), to create submission compliant SAS transport files and perform pharma specific dataset level validation checks; and [*logrx*](https://github.com/pharmaverse/logrx) (ex-*timber*), to build log to support reproducibility and traceability of an R script. +In 2020, Michael Stackhouse (Atorus) and Michael Rimler (GSK) talked and formed a partnership between their companies to develop a few more packages, including [*metacore*](https://github.com/atorus-research/metacore), to read, store and manipulate metadata for ADaMs/SDTMs in a standardized object; [*xportr*](https://github.com/atorus-research/xportr), to create submission compliant SAS transport files and perform pharma specific dataset level validation checks; and [*logrx*](https://github.com/pharmaverse/logrx) (ex-*timber*), to build log to support reproducibility and traceability of an R script. -Around the same time, Thomas Neitmann (currently at Denali Therapeutics, then at Roche) and Rimler discovered that both were working with ADaM in R, so Neitmann, Ross and Rimler saw an opportunity there and GSK started their partnership with Roche to build and release [*admiral*](https://github.com/pharmaverse/admiral) package. +Around the same time, Thomas Neitmann (currently at Denali Therapeutics, then at Roche) and Michael Rimler (GSK) discovered that both were working with ADaM in R, so Thomas Neitmann (currently at Denali Therapeutics, then at Roche), Ross Farrugia (Roche) and Michael Rimler (GSK) saw an opportunity there and GSK started their partnership with Roche to build and release [*admiral*](https://github.com/pharmaverse/admiral) package. The idea of working together, the sense of community, and the appetite from organizations built more and more, with incentive and priority established up into the programming heads council. -Janssen had a huge effort in building R capabilities going on as well, by releasing [*tidytlg*](https://github.com/pharmaverse/tidytlg) and [*envsetup*](https://github.com/pharmaverse/envsetup)), so eventually Rimler, Stackhouse and Ross formalized [pharmaverse](https://pharmaverse.org/) and formed the council, adding in Sumesh (Janssen) and Ari Siggaard Knoph (Novo Nordisk) later joined as the fifth council member. +Janssen had a huge effort in building R capabilities going on as well, by releasing [*tidytlg*](https://github.com/pharmaverse/tidytlg) and [*envsetup*](https://github.com/pharmaverse/envsetup)), so eventually Michael Rimler (GSK), Michael Stackhouse (Atorus) and Ross Farrugia (Roche) formalized [pharmaverse](https://pharmaverse.org/) and formed the council, adding in Sumesh Kalappurakal (Janssen) and Ari Siggaard Knoph (Novo Nordisk) later joined as the fifth council member. -**Release, growth and developments** +## Release, growth and developments At the end of their presentation ["Closing the Gap: Creating an End to End R Package Toolkit for the Clinical Reporting Pipeline."](https://www.youtube.com/watch?v=NW9qp5QOlIU), in [R/Pharma 2021](https://rinpharma.com/event/rinpharma2021/), Ben Straub (GSK) and Eli Miller (Atorus) welcomed the community to the [pharmaverse](https://pharmaverse.org/), a curated collection of packages developed by various pharmaceutical companies to support open-source clinical workflows. @@ -83,13 +83,12 @@ Also, it was established as not being a consortium, which means that founders do Some individuals and companies maintain them but often allowing for community contributions and being licensed permissively so that there is always a feeling of community ownership. The focus of [pharmaverse](https://pharmaverse.org/) early on, and today, is on inter organization cooperation, to build an environment where, if organizations identify that they have a joint problem that they want to solve, this is the right space to work on and release it. -[Pharmaverse](https://pharmaverse.org/) has grown a lot, at the time of writing this post we have >25 packages recommended in [pharmaverse](https://pharmaverse.org/e2eclinical/), and this has led to a partnership with [PHUSE](https://phuse.global/About_PHUSE) to get support from their organization and platform, and because they are eager to advance and support [pharmaverse mission](https://pharmaverse.org/charter/). +[Pharmaverse](https://pharmaverse.org/) has grown a lot, at the time of writing this post we have \>25 packages recommended in [pharmaverse](https://pharmaverse.org/e2eclinical/), and this has led to a partnership with [PHUSE](https://phuse.global/About_PHUSE) to get support from their organization and platform, and because they are eager to advance and support [pharmaverse mission](https://pharmaverse.org/charter/). Despite all its structure, it is impossible to say that we have a single solution for each clinical reporting analysis when it comes to [pharmaverse](https://pharmaverse.org/), a single pathway is impractical. Instead, it is necessary to accept viable tools fitting different pathways into [pharmaverse](https://pharmaverse.org/) to direct and give people options as to what might work for them. After all, even though we live together as a community, we still have our own unique internal problems. - ![Sample of pharmaverse packages](logos.png)