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tree-data.json
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tree-data.json
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[
{
"id": 1,
"value": "transcript_variant",
"label": "Transcript variant",
"children": [2, 19, 25, 29, 30]
},
{
"id": 2,
"value": "coding_variant",
"label": "Coding variant",
"children": [3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18],
"parent": 1
},
{
"id": 3,
"value": "coding_sequence_variant",
"label": "Coding sequence variant",
"size": 18057,
"description": "A sequence variant that changes the coding sequence",
"parent": 2
},
{
"id": 4,
"value": "feature_elongation",
"label": "Feature elongation",
"size": 0,
"description": "A sequence variant that causes the extension of a genomic feature, with regard to the reference sequence",
"parent": 2
},
{
"id": 5,
"value": "feature_truncation",
"label": "Feature truncation",
"size": 0,
"description": "A sequence variant that causes the reduction of a genomic feature, with regard to the reference sequence",
"parent": 2
},
{
"id": 6,
"value": "frameshift_variant",
"label": "Frameshift variant",
"size": 506417,
"description": "A sequence variant which causes a disruption of the translational reading frame, because the number of nucleotides inserted or deleted is not a multiple of three",
"parent": 2
},
{
"id": 7,
"value": "incomplete_terminal_codon_variant",
"label": "Incomplete terminal codon variant",
"size": 3443,
"description": "A sequence variant where at least one base of the final codon of an incompletely annotated transcript is changed",
"parent": 2
},
{
"id": 8,
"value": "inframe_deletion",
"label": "Inframe deletion",
"size": 143302,
"description": "An inframe non synonymous variant that deletes bases from the coding sequence",
"parent": 2
},
{
"id": 9,
"value": "inframe_insertion",
"label": "Inframe insertion",
"size": 50924,
"description": "An inframe non synonymous variant that inserts bases into in the coding sequence",
"parent": 2
},
{
"id": 10,
"value": "missense_variant",
"label": "Missense variant",
"size": 12385885,
"description": "A sequence variant, that changes one or more bases, resulting in a different amino acid sequence but where the length is preserved",
"parent": 2
},
{
"id": 11,
"value": "NMD_transcript_variant",
"label": "NMD transcript variant",
"size": 20962310,
"description": "A variant in a transcript that is the target of NMD",
"parent": 2
},
{
"id": 12,
"value": "protein_altering_variant",
"label": "Protein altering variant",
"size": 3482,
"description": "A sequence_variant which is predicted to change the protein encoded in the coding sequence",
"parent": 2
},
{
"id": 13,
"value": "synonymous_variant",
"label": "Synonymous variant",
"size": 6340518,
"description": "A sequence variant where there is no resulting change to the encoded amino acid",
"parent": 2
},
{
"id": 14,
"value": "start_lost",
"label": "Start lost",
"size": 38719,
"description": "A codon variant that changes at least one base of the canonical start codon",
"parent": 2
},
{
"id": 15,
"value": "stop_gained",
"label": "Stop gained",
"size": 402831,
"description": "A sequence variant whereby at least one base of a codon is changed, resulting in a premature stop codon, leading to a shortened transcript",
"parent": 2
},
{
"id": 16,
"value": "stop_lost",
"label": "Stop lost",
"size": 16247,
"description": "A sequence variant where at least one base of the terminator codon (stop) is changed, resulting in an elongated transcript",
"parent": 2
},
{
"id": 17,
"value": "start_retained_variant",
"label": "Start retained variant",
"size": 585,
"description": "A sequence variant where at least one base in the start codon is changed, but the start remains",
"parent": 2
},
{
"id": 18,
"value": "stop_retained_variant",
"label": "Stop retained variant",
"size": 7754,
"description": "A sequence variant where at least one base in the terminator codon is changed, but the terminator remains",
"parent": 2
},
{
"id": 19,
"label": "Non-coding variant",
"children": [20, 21, 22, 23, 24],
"parent": 1
},
{
"id": 20,
"value": "3_prime_UTR_variant",
"label": "3 prime UTR variant",
"size": 4109311,
"description": "A UTR variant of the 3' UTR",
"parent": 19
},
{
"id": 21,
"value": "5_prime_UTR_variant",
"label": "5 prime UTR variant",
"description": "A UTR variant of the 5' UTR",
"parent": 19,
"children": [43]
},
{
"id": 22,
"value": "intron_variant",
"label": "Intron variant",
"size": 212366571,
"description": "A transcript variant occurring within an intron",
"parent": 19
},
{
"id": 23,
"value": "non_coding_transcript_exon_variant",
"label": "Non coding transcript exon variant",
"size": 7450628,
"description": "A sequence variant that changes non-coding exon sequence in a non-coding transcript",
"parent": 19
},
{
"id": 24,
"value": "non_coding_transcript_variant",
"label": "Non coding transcript variant",
"size": 52390424,
"description": "A transcript variant of a non coding RNA gene",
"parent": 19
},
{
"id": 25,
"label": "Splice variant",
"children": [26, 27, 28],
"parent": 1
},
{
"id": 26,
"value": "splice_acceptor_variant",
"label": "Splice acceptor variant",
"size": 172987,
"description": "A splice variant that changes the 2 base region at the 3' end of an intron",
"parent": 25
},
{
"id": 27,
"value": "splice_donor_variant",
"label": "Splice donor variant",
"size": 210311,
"description": "A splice variant that changes the 2 base region at the 5' end of an intron",
"parent": 25
},
{
"id": 28,
"value": "splice_region_variant",
"label": "Splice region variant",
"size": 2785532,
"description": "A sequence variant in which a change has occurred within the region of the splice site, either within 1-3 bases of the exon or 3-8 bases of the intron",
"parent": 25
},
{
"id": 29,
"value": "transcript_ablation",
"label": "Transcript ablation",
"size": 18,
"description": "A feature ablation whereby the deleted region includes a transcript feature",
"parent": 1
},
{
"id": 30,
"value": "transcript_amplification",
"label": "Transcript amplification",
"size": 0,
"description": "A feature amplification of a region containing a transcript",
"parent": 1
},
{
"id": 31,
"label": "Regulatory variant",
"children": [32, 33, 34, 35, 36, 37, 38]
},
{
"id": 32,
"value": "mature_miRNA_variant",
"label": "Mature miRNA variant",
"size": 6871,
"description": "A transcript variant located with the sequence of the mature miRNA",
"parent": 31
},
{
"id": 33,
"value": "regulatory_region_ablation",
"label": "Regulatory region ablation",
"size": 0,
"description": "A feature ablation whereby the deleted region includes a regulatory region",
"parent": 31
},
{
"id": 34,
"value": "regulatory_region_amplification",
"label": "Regulatory region amplification",
"size": 0,
"description": "A feature amplification of a region containing a regulatory region",
"parent": 31
},
{
"id": 35,
"value": "regulatory_region_variant",
"label": "Regulatory region variant",
"size": 0,
"description": "A sequence variant located within a regulatory region",
"parent": 31
},
{
"id": 36,
"value": "TF_binding_site_variant",
"label": "TF binding site variant",
"size": 0,
"description": "A sequence variant located within a transcription factor binding site",
"parent": 31
},
{
"id": 37,
"value": "TFBS_ablation",
"label": "TFBS ablation",
"size": 0,
"description": "A feature ablation whereby the deleted region includes a transcription factor binding site",
"parent": 31
},
{
"id": 38,
"value": "TFBS_amplification",
"label": "TFBS amplification",
"size": 0,
"description": "A feature amplification of a region containing a transcription factor binding site",
"parent": 31
},
{
"id": 39,
"label": "Intergenic variant",
"children": [40, 41, 42]
},
{
"id": 40,
"value": "downstream_gene_variant",
"label": "Downstream gene variant",
"size": 0,
"description": "A sequence variant located 3' of a gene",
"parent": 39
},
{
"id": 41,
"value": "intergenic_variant",
"label": "Intergenic variant",
"size": 38329053,
"description": "A sequence variant located in the intergenic region, between genes",
"parent": 39
},
{
"id": 42,
"value": "upstream_gene_variant",
"label": "Upstream gene variant",
"size": 0,
"description": "A sequence variant located 5' of a gene",
"parent": 39
},
{
"id": 43,
"value": "shine_dalgarno_sequence",
"label": "Shine–Dalgarno sequence",
"description": "ribosomal binding site in bacterial and archaeal messenger RNA",
"parent": 21,
"children": [44]
},
{
"id": 44,
"value": "pyrimidine",
"label": "Pyrimidine",
"description": "aromatic heterocyclic organic compound similar to pyridine",
"parent": 43,
"children": [45]
},
{
"id": 45,
"value": "pyrimidine2",
"label": "Pyrimidine2 really long-long-long label",
"description": "ribosomal binding site in bacterial and archaeal messenger RNA",
"parent": 44,
"children": [46]
},
{
"id": 46,
"value": "pyrimidine2",
"label": "Pyrimidine2 really long-long-long label 2",
"size": 1546374,
"description": "ribosomal binding site in bacterial and archaeal messenger RNA",
"parent": 45
}
]