Code supplement to Chronotype_Neurobiological_Basis Study

This repository contains the code used to analysis the data presented in the "On the Neurobiological Basis of Chronotype: Insights from a Multimodal Population Neuroscience Study" paper. Current citation: https://doi.org/10.21203/rs.3.rs-4095105/v1

Scripts are saved in scrpit/ folder：

1. LDA_analysis.ipynb is an analysis scripts to investigate the multivariate brain patterns linked to chronotype.
2. PLS_actigraphy.ipynb is an analysis scripts to investigate the cross-associations between brain patterns and daily activity patterns.

Results are save in results/ folder：

1. LDA_sMRI_coef_5-95CI_all.csv is the result of LDA analysis on strutual MRI with 5-95% confidence interval.
2. LDA_dMRI_coef_5-95CI_all.csv is the result of LDA analysis on diffusion MRI with 5-95% confidence interval.
3. LDA_sexdiff_sMRI_coef_5-95CI_all.csv is the result of sex differences analysis on strutual MRI with 5-95% confidence interval.
4. LDA_sexdiff_dMRI_coef_5-95CI_all.csv is the result of sex differences analysis analysis on diffusion MRI with 5-95% confidence interval.
5. PLS_Sig_x_loading.csv is x loadings derived from the PLS analysis. Each column in the x loadings corresponds to a latent component, and each row corresponds to an brain feature.
6. PLS_Sig_y_loading.csv is the y loadings derived from the PLS analysis. Each column in the x loadings corresponds to a latent component, and each row corresponds to each hour of the day.
7. Phewas_chronotype_hits.csv is the results of PheWAS analysis (hits above BON correction).
8. Phewas_corrdf_all.csv is the full results of PheWAS analysis.