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YunaBlum authored Nov 30, 2024
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### Provided cell population reference data


The organizers provide cell population reference profiles for PDAC. Three reference datasets are available: **bulk RNAseq of isolated cell populations, bulk methylation profiles of isolated cell populations and single-cell RNAseq**. All references are using publicly available data. Each reference type contains 5 cell types: immune cells (immune), fibroblasts (fibro), endothelial cells (endo), and classical (classic) and basal-like (basal) tumor cells.
The organizers provide cell population reference profiles for PDAC (pancreatic cancer). Three reference datasets are available: **bulk RNAseq of isolated cell populations, bulk methylation profiles of isolated cell populations and single-cell RNAseq**. All references are using publicly available data. Each reference type contains 5 cell types: immune cells (immune), fibroblasts (fibro), endothelial cells (endo), and classical (classic) and basal-like (basal) tumor cells.

\- **bulk RNAseq cell populations**: immune cells and fibroblasts transcriptomic profiles were retrieved from the GTEx Analysis V10 ([GTEx portal](https://www.gtexportal.org/home/downloads/adult-gtex/bulk_tissue_expression), link to paper [1](https://www.liebertpub.com/doi/full/10.1089/bio.2015.0032) [2](https://www.nature.com/articles/ng.2653)), endothelial cell transcriptomic profiles were retrieved from GEO [GSE135123](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE135123) (link to [paper](https://pmc.ncbi.nlm.nih.gov/articles/PMC6890669/)). Basal-like and classical tumor cell transcriptomic profiles were retrieved from [this paper](https://pmc.ncbi.nlm.nih.gov/articles/PMC6082139/). **Preprocess**: this reference data has been normalized using edgeR.

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