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Grating interferometry has been developed on a wide variety of sources and applications in the last decade, and it is reaching clinical significance in specific fields such as mammography and lung imaging. This is the result of the sensitivity of this technique to additional physical signals, namely differential phase contrast and dark-field contrast. While these provide great insights in the physical properties of samples, and most notably soft tissues, thanks to benefits in contrast and sensitivity to high-frequency components, general purpose applications to medicine or material sciences have been limited.
One of the main issues is the need for higher radiation energy: between 60 and 120 kV for medical imaging, and above for industrial nondestructive testing. In this work we present the realization of several interferometers that can be used in this energy range. Moreover imaging and quantitative modelling are presented, aiming at establishing a direct link between the recorded images and physical properties of interest in a sample.
The main results are the realization and study of grating interferometers for high energies in the edge-on geometry, that is a one-dimensional system easily adapted to arbitrarily high beam energies; the design and installation of two-dimensional systems for laboratory sources with an energy up to 120 kVp within the current limitations of grating fabrication technologies. Finally, experiments on these setups allowed us to build a complete quantitative model of lung alveolar microstructures connecting the ground truth as recorded in a high-resolution microtomographic scan with a synchrotron X-ray source to radiographic dark-field imaging on a laboratory source.
A Classic Thesis Style v4.4 An Homage to The Elements of Typographic Style Copyright (C) 2017 André Miede http://www.miede.de
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